scholarly journals Kappa Opioid Receptor Localization and Coupling to Nitric Oxide Production in Cells of the Anterior Chamber

2011 ◽  
Vol 52 (8) ◽  
pp. 5233 ◽  
Author(s):  
Karen R. Russell-Randall ◽  
Juanita Dortch-Carnes
Keyword(s):  
Nitric Oxide ◽  
Anterior Chamber ◽  
Opioid Receptor ◽  
Kappa Opioid Receptor ◽  
Nitric Oxide Production ◽  
Kappa Opioid ◽  
Oxide Production ◽  
Receptor Localization ◽  
In Cells

scholarly journals Neuroprotective κ-Opioid Receptor Agonist BRL 52537 Attenuates Ischemia-Evoked Nitric Oxide Production In Vivo in Rats

Stroke ◽  
2003 ◽  
Vol 34 (6) ◽  
pp. 1533-1538 ◽  
Author(s):  
Toru Goyagi ◽  
Thomas J.K. Toung ◽  
Jeffrey R. Kirsch ◽  
Richard J. Traystman ◽  
Raymond C. Koehler ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Opioid Receptor ◽  
Receptor Agonist ◽  
Nitric Oxide Production ◽  
Oxide Production ◽  
Opioid Receptor Agonist

scholarly journals Nitric Oxide Stimulates Acute Pancreatitis Pain via Activating the NF-κB Signaling Pathway and Inhibiting the Kappa Opioid Receptor

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Mengwen Xue ◽  
Liang Han ◽  
Weikun Qian ◽  
Jie Li ◽  
Tao Qin ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Acute Pancreatitis ◽  
Opioid Receptor ◽  
Pain Treatment ◽  
Kappa Opioid Receptor ◽  
Clinical Feature ◽  
Kappa Opioid ◽  
No Donor

Pain is the most important clinical feature of acute pancreatitis (AP); however, its specific mechanism is currently unclear. In this study, we showed that AP caused an increase in nitric oxide (NO) secretion, activated the NF-κB pathway in the dorsal root ganglia (DRGs), and caused pain. We established an AP model in vivo and tested the expression of NO, the kappa opioid receptor (KOR), and pain factors. We showed that NO in AP was significantly elevated and increased the expression of pain factors. Next, by treating DRGs in vitro, it was found that NO activated the NF-κB pathway; conversely, NF-κB had no effect on NO. Moreover, inhibition of NF-κB promoted the KOR, whereas NF-κB did not change after KOR activation. Finally, behavioral experiments showed that a NO donor increased the pain behavior of mice, while a NO scavenger, NF-κB inhibitor, or KOR agonist attenuated the pain response in mice. These results suggest that iNOS/NO/NF-κB/KOR may be a key mechanism of pain in AP, providing a theoretical basis for the use of peripheral-restricted KOR agonists for pain treatment in AP.

scholarly journals NITRIC OXIDE PRODUCTION IN CELLS DERIVED FROM THE HUMAN JOINT

Rheumatology ◽  
1996 ◽  
Vol 35 (3) ◽  
pp. 207-212 ◽  
Author(s):  
P. S. GRABOWSKI ◽  
H. MACPHERSON ◽  
S. H. RALSTON
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Production ◽  
Oxide Production ◽  
Human Joint ◽  
In Cells

scholarly journals Nitric oxide production and apoptosis in cells of the meniscus during experimental osteoarthritis

1999 ◽  
Vol 42 (10) ◽  
pp. 2123-2131 ◽  
Author(s):  
Sanshiro Hashimoto ◽  
Kenji Takahashi ◽  
Robert L. Ochs ◽  
Richard D. Coutts ◽  
David Amiel ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Production ◽  
Oxide Production ◽  
Experimental Osteoarthritis ◽  
In Cells

502: Pressure Induces Nitric Oxide Production by Human Ureteral Cells in Vitro

2005 ◽  
Vol 173 (4S) ◽  
pp. 137-137
Author(s):  
Michael M. Ohebshalom ◽  
Stella K. Maeng ◽  
Jie Chen ◽  
Dix P. Poppas ◽  
Diane Felsen
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Production ◽  
Oxide Production
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