scholarly journals A Potential Role for Angiopoietin 2 in the Regulation of the Blood–Retinal Barrier in Diabetic Retinopathy

2011 ◽  
Vol 52 (6) ◽  
pp. 3784 ◽  
Author(s):  
Sampathkumar Rangasamy ◽  
Ramprasad Srinivasan ◽  
Joann Maestas ◽  
Paul G. McGuire ◽  
Arup Das
Keyword(s):  
Diabetic Retinopathy ◽  
Potential Role ◽  
Blood Retinal Barrier ◽  
Angiopoietin 2

Angiopoietin-2-related modulation of retinal angiogenesis – A new model for diabetic retinopathy

2005 ◽  
Vol 113 (S 1) ◽  
Author(s):  
P Wagner ◽  
Y Feng ◽  
F vom Hagen ◽  
S Hoffmann ◽  
J Lin ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
New Model ◽  
Retinal Angiogenesis ◽  
Angiopoietin 2

The potential role of m6A RNA methylation in diabetic retinopathy

2021 ◽  
pp. 108616
Author(s):  
Nidhi Kumari ◽  
Aditi Karmakar ◽  
Md Maqsood Ahamad Khan ◽  
Senthil Kumar Ganesan
Keyword(s):  
Diabetic Retinopathy ◽  
Potential Role ◽  
Rna Methylation ◽  
M6a Rna Methylation

scholarly journals Bone Morphogenetic Proteins and Diabetic Retinopathy

Biomolecules ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 593
Author(s):  
Khaled Elmasry ◽  
Samar Habib ◽  
Mohamed Moustafa ◽  
Mohamed Al-Shabrawey
Keyword(s):  
Diabetic Retinopathy ◽  
Bone Morphogenetic Proteins ◽  
Potential Role ◽  
Microvascular Dysfunction ◽  
Cardiovascular Complications ◽  
Bmp Signaling ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Retinal Inflammation ◽  
Underlying Mechanisms

Bone morphogenetic proteins (BMPs) play an important role in bone formation and repair. Recent studies underscored their essential role in the normal development of several organs and vascular homeostasis in health and diseases. Elevated levels of BMPs have been linked to the development of cardiovascular complications of diabetes mellitus. However, their particular role in the pathogenesis of microvascular dysfunction associated with diabetic retinopathy (DR) is still under-investigated. Accumulated evidence from our and others’ studies suggests the involvement of BMP signaling in retinal inflammation, hyperpermeability and pathological neovascularization in DR and age-related macular degeneration (AMD). Therefore, targeting BMP signaling in diabetes is proposed as a potential therapeutic strategy to halt the development of microvascular dysfunction in retinal diseases, particularly in DR. The goal of this review article is to discuss the biological functions of BMPs, their underlying mechanisms and their potential role in the pathogenesis of DR in particular.

Mechanistic Insights into Immunological Therapy for Targeting Diabetic Retinopathy

2021 ◽  
Vol 5 (3) ◽  
pp. 01-05
Author(s):  
Imteyaz Qamar
Keyword(s):  
Diabetic Retinopathy ◽  
Progressive Disease ◽  
Common Complication ◽  
Blood Retinal Barrier ◽  
Immunological Therapy ◽  
Tnf Α ◽  
Capillary Occlusion ◽  
Inflammatory Molecules ◽  
Inflammatory Effect

Diabetic retinopathy (DR) is a common complication amongst patients that have diabetes. It is a leading cause of blindness in middle age people. A large proportion of patients who have diabetes develop retinopathy. There are several immunological reasons associated with the pathophysiology of this disease. Role of several mediators that increase the oxidative stress and have a pro-inflammatory effect which leads to capillary occlusion and neovascularization (NV). Increased vasopermeability due to disruption of the blood-retinal barrier (BRB) leading to diabetic macular edema (DME). Immunotherapies utilise different compounds and target various inflammatory molecules like TNF-α and pathways such as PPARγ for treatment of this progressive disease. Inflammatory and pro-inflammatory pathways are found to have an essential role in promoting DR; therefore, targeting them provides a useful technique for curing DR.

scholarly journals Epigenetic modifications in hyperhomocysteinemia: potential role in diabetic retinopathy and age-related macular degeneration

Oncotarget ◽  
2018 ◽  
Vol 9 (16) ◽  
pp. 12562-12590 ◽  
Author(s):  
Khaled Elmasry ◽  
Riyaz Mohamed ◽  
Isha Sharma ◽  
Nehal M. Elsherbiny ◽  
Yutao Liu ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Macular Degeneration ◽  
Potential Role ◽  
Epigenetic Modifications ◽  
Age Related Macular Degeneration ◽  
Age Related

Erythropoietin protects outer blood‐retinal barrier in experimental diabetic retinopathy by up‐regulating ZO‐1 and occludin

2019 ◽  
Vol 47 (9) ◽  
pp. 1182-1197 ◽  
Author(s):  
Chaoyang Zhang ◽  
Hai Xie ◽  
Qian Yang ◽  
Yiting Yang ◽  
Weiye Li ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Blood Retinal Barrier
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