scholarly journals Retinal Ganglion Cell Loss in a Rat Ocular Hypertension Model Is Sectorial and Involves Early Optic Nerve Axon Loss

2011 ◽  
Vol 52 (1) ◽  
pp. 434 ◽  
Author(s):  
Ileana Soto ◽  
Mary E. Pease ◽  
Janice L. Son ◽  
Xiaohai Shi ◽  
Harry A. Quigley ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Ocular Hypertension ◽  
Retinal Ganglion Cell ◽  
Cell Loss ◽  
Retinal Ganglion ◽  
Nerve Axon ◽  
Axon Loss

scholarly journals Transgenic inhibition of astroglial NF-κB protects from optic nerve damage and retinal ganglion cell loss in experimental optic neuritis

2012 ◽  
Vol 9 (1) ◽  
Author(s):  
Roberta Brambilla ◽  
Galina Dvoriantchikova ◽  
David Barakat ◽  
Dmitry Ivanov ◽  
John R Bethea ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Neuritis ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Loss ◽  
Nerve Damage ◽  
Retinal Ganglion ◽  
Optic Nerve Damage

Rapid and protracted phases of retinal ganglion cell loss follow axotomy in the optic nerve of adult rats

1993 ◽  
Vol 24 (1) ◽  
pp. 23-36 ◽  
Author(s):  
Maria-Paz Villegas-Pérez ◽  
Manuel Vidal-Sanz ◽  
Michael Rasminsky ◽  
Garth M. Bray ◽  
Albert J. Aguayo
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Loss ◽  
Retinal Ganglion ◽  
Adult Rats

scholarly journals Comparison of Retinal Nerve Fiber Layer Thinning and Retinal Ganglion Cell Loss After Optic Nerve Transection in Adult Albino Rats

2015 ◽  
Vol 56 (8) ◽  
pp. 4487 ◽  
Author(s):  
Giuseppe Rovere ◽  
Francisco M. Nadal-Nicolás ◽  
Marta Agudo-Barriuso ◽  
Paloma Sobrado-Calvo ◽  
Leticia Nieto-López ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Nerve Fiber ◽  
Retinal Ganglion Cell ◽  
Retinal Nerve Fiber Layer ◽  
Cell Loss ◽  
Albino Rats ◽  
Retinal Ganglion ◽  
Nerve Transection ◽  
Fiber Layer

scholarly journals Modulation of Sirt1-mTORC1 Pathway in Microglia Attenuates Retinal Ganglion Cell Loss After Optic Nerve Injury

2021 ◽  
Vol Volume 14 ◽  
pp. 6857-6869
Author(s):  
Qianxue Mou ◽  
Ke Yao ◽  
Meng Ye ◽  
Bowen Zhao ◽  
Yuanyuan Hu ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Nerve Injury ◽  
Retinal Ganglion Cell ◽  
Cell Loss ◽  
Retinal Ganglion ◽  
Optic Nerve Injury ◽  
Mtorc1 Pathway

scholarly journals Early-Stage Ocular Hypertension Alters Retinal Ganglion Cell Synaptic Transmission in the Visual Thalamus

2019 ◽  
Author(s):  
Ashish Bhandari ◽  
Jennie C. Smith ◽  
Yang Zhang ◽  
Lisa Reid ◽  
Toni Goeser ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Ocular Hypertension ◽  
Retinal Ganglion Cell ◽  
Dorsal Lateral Geniculate Nucleus ◽  
Retinal Ganglion ◽  
Mouse Line ◽  
Reporter Mouse ◽  
The Brain ◽  
Relay Neurons

AbstractAxonopathy is a hallmark of many neurodegenerative diseases including glaucoma, where elevated intraocular pressure (ocular hypertension, OHT) stresses retinal ganglion cell (RGC) axons as they exit the eye and form the optic nerve. OHT causes early changes in the optic nerve such as axon atrophy, transport inhibition, and gliosis. Importantly, many of these changes appear to occur prior to irreversible neuronal loss, making them promising points for early diagnosis of glaucoma. It is unknown whether OHT has similarly early effects on the function of RGC output to the brain. To test this possibility, we elevated eye pressure in mice by anterior chamber injection of polystyrene microbeads. 5 weeks post-injection, bead-injected eyes showed a modest RGC loss in the peripheral retina, as evidenced by RBPMS antibody staining. Additionally, we observed reduced dendritic complexity and lower spontaneous spike rate of On-αRGCs, targeted for patch clamp recording and dye filling using a Opn4-cre reporter mouse line. To determine the influence of OHT on retinal projections to the brain, we expressed Channelrhodopsin-2 (ChR2) in melanopsin-expressing retinal ganglion cells by crossing the Opn4-cre mouse line with a ChR2-reporter mouse line and recorded post-synaptic responses in thalamocortical relay neurons in the dorsal lateral geniculate nucleus (dLGN) of the thalamus evoked by stimulation with 460 nm light. The use of a Opn4-cre reporter system allowed for expression of ChR2 in a narrow subset of RGCs responsible for image-forming vision in mice. Five weeks following OHT induction, paired pulse and high-frequency stimulus train experiments revealed that presynaptic vesicle release probability at retinogeniculate synapses was elevated. Additionally, miniature synaptic current frequency was slightly reduced in brain slices from OHT mice and proximal dendrites of post-synaptic dLGN relay neurons, assessed using a Sholl analysis, showed a reduced complexity. Strikingly, these changes occurred prior to major loss of RGCs labeled with the Opn4-Cre mouse, as indicated by immunofluorescence staining of ChR2-expressing retinal neurons. Thus, OHT leads to pre- and post-synaptic functional and structural changes at retinogeniculate synapses. Along with RGC dendritic remodeling and optic nerve transport changes, these retinogeniculate synaptic changes are among the earliest signs of glaucoma.

Ocular hypertension impairs optic nerve axonal transport leading to progressive retinal ganglion cell degeneration

2010 ◽  
Vol 90 (1) ◽  
pp. 168-183 ◽  
Author(s):  
Manuel Salinas-Navarro ◽  
Luis Alarcón-Martínez ◽  
Francisco J. Valiente-Soriano ◽  
Manuel Jiménez-López ◽  
Sergio Mayor-Torroglosa ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Ocular Hypertension ◽  
Axonal Transport ◽  
Retinal Ganglion Cell ◽  
Retinal Ganglion ◽  
Cell Degeneration
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