The Monocyte Chemokine Receptor CX3CR1 Does Not Play a Significant Role in the Pathogenesis of Experimental Autoimmune Uveoretinitis

2010 ◽  
Vol 51 (10) ◽  
pp. 5121 ◽  
Author(s):  
Jelena Kezic ◽  
Paul G. McMenamin
Keyword(s):  
Significant Role ◽  
Chemokine Receptor ◽  
Experimental Autoimmune Uveoretinitis ◽  
Receptor Cx3cr1 ◽  
Experimental Autoimmune

scholarly journals Interaction of Tau with the chemokine receptor, CX3CR1 and its effect on microglial activation, migration and proliferation

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Hariharakrishnan Chidambaram ◽  
Rashmi Das ◽  
Subashchandrabose Chinnathambi
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Significant Role ◽  
Chemokine Receptor ◽  
Pathological Condition ◽  
Senile Plaques ◽  
Amyloid Β ◽  
Paired Helical Filaments ◽  
Quiescent State ◽  
Receptor Cx3cr1

Abstract Alzheimer’s disease (AD) is a neurodegenerative disease that leads to progressive loss of memory and dementia. The pathological hallmarks of AD include extracellular accumulation of amyloid-β peptides forming senile plaques and intracellular accumulation of Tau oligomers and filamentous species. Tau is a microtubule-binding protein that stabilizes tubulin to form microtubules under physiological condition. In AD/ pathological condition, Tau detaches from microtubules and aggregates to form oligomers of different sizes and filamentous species such as paired helical filaments. Microglia are the resident brain macrophages that are involved in the phagocytosis of microbes, cellular debris, misfolded and aggregated proteins. Chemokine receptor, CX3CR1 is mostly expressed on microglia and is involved in maintaining the microglia in a quiescent state by binding to its ligand, fractalkine (CX3CL1), which is expressed in neurons as both soluble or membrane-bound state. Hence, under physiological conditions, the CX3CR1/CX3CL1 axis plays a significant role in maintaining the central nervous system (CNS) homeostasis. Further, CX3CR1/CX3CL1 signalling is involved in the synthesis of anti-inflammatory cytokines and also has a significant role in cytoskeletal rearrangement, migration, apoptosis and proliferation. In AD brain, the expression level of fractalkine is reduced, and hence Tau competes to interact with its receptor, CX3CR1. In microglia, phagocytosis and internalization of extracellular Tau species occurs in the presence of a chemokine receptor, CX3CR1 which binds directly to Tau and promotes its internalization. In this review, the pathophysiological roles of CX3CR1/fractalkine signalling in microglia and neurons at different stages of Alzheimer’s disease and the possible role of CX3CR1/Tau signalling has been widely discussed.

Chemokine and chemokine receptor expression during experimental autoimmune uveoretinitis in mice

2003 ◽  
Vol 241 (2) ◽  
pp. 111-115 ◽  
Author(s):  
Hiroshi Keino ◽  
Masaru Takeuchi ◽  
Takeshi Kezuka ◽  
Naoyuki Yamakawa ◽  
Rintaroh Tsukahara ◽  
...  
Keyword(s):  
Chemokine Receptor ◽  
Receptor Expression ◽  
Chemokine Receptor Expression ◽  
Experimental Autoimmune Uveoretinitis ◽  
Experimental Autoimmune

Chemokine receptor CX3CR1

2009 ◽  
Author(s):  
Astrid Cardona ◽  
Richard Ransohoff
Keyword(s):  
Chemokine Receptor ◽  
Receptor Cx3cr1

Inhibition of cellular transfer of experimental autoimmune uveoretinitis by Rapamycin

1993 ◽  
Vol 1 (3) ◽  
pp. 269-273 ◽  
Author(s):  
FranÇOis G. Roberge ◽  
Alexander Kozhich ◽  
Chi-Chao Chan ◽  
Daniel F. Martin ◽  
Robert B. Nussenblatt ◽  
...  
Keyword(s):  
Experimental Autoimmune Uveoretinitis ◽  
Experimental Autoimmune

Everolimus improves experimental autoimmune uveoretinitis

2012 ◽  
Vol 105 ◽  
pp. 43-52 ◽  
Author(s):  
M. Hennig ◽  
D. Bauer ◽  
S. Wasmuth ◽  
M. Busch ◽  
K. Walscheid ◽  
...  
Keyword(s):  
Experimental Autoimmune Uveoretinitis ◽  
Experimental Autoimmune

Conserved T Cell Receptor Complementarity-Determining Region 3 of Ocular T Cells in Mice with Experimental Autoimmune Uveoretinitis

1999 ◽  
Vol 31 (4) ◽  
pp. 249-255 ◽  
Author(s):  
Reiko Uehara ◽  
Koushi Fujisawa ◽  
Takeshi Kezuka ◽  
Jun-Ichi Sakai ◽  
Kusuki Nishioka ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Experimental Autoimmune Uveoretinitis ◽  
Complementarity Determining Region ◽  
Experimental Autoimmune
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