scholarly journals Multifocal ERG Defects Associated with Insufficient Long-Term Glycemic Control in Adolescents with Type 1 Diabetes

2010 ◽  
Vol 51 (10) ◽  
pp. 5297 ◽  
Author(s):  
Ekta Lakhani ◽  
Tom Wright ◽  
Mohamed Abdolell ◽  
Carol Westall
Keyword(s):  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Multifocal Erg

scholarly journals 30-Year Cardiovascular Disease in Type 1 Diabetes: Risk and Risk Factors Differ by Long-Term Patterns of Glycemic Control

2021 ◽  
Author(s):  
Rachel G. Miller ◽  
Trevor J. Orchard ◽  
Tina Costacou
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Latent Class ◽  
Diabetes Duration ◽  
Cvd Risk ◽  
High Hba1c

<b>Objective:</b> We hypothesized that there is heterogeneity in long-term patterns of glycemic control with respect to cardiovascular disease (CVD) development in type 1 diabetes and that risk factors for CVD differ by glycemic control pattern. Thus, we estimated associations between data-derived latent HbA1c trajectories and 30-year CVD risk in the Pittsburgh Epidemiology of Diabetes Complications (EDC) study of childhood-onset (<17 years old) type 1 diabetes.<b> </b> <p><b>Research Design and Methods: </b>Participants (n=536 with ≥2 HbA1c measurements [median 6] and CVD-free at baseline; mean age 27 and diabetes duration 18 years) were followed from 1986-88 to 2016-18 to ascertain CVD incidence (CVD death, myocardial infarction, stroke, coronary revascularization or blockage ≥50%, ischemic ECG, or angina). Latent HbA1c trajectories and their association with time-to-CVD incidence were simultaneously assessed using Joint Latent Class Mixed Models.</p> <p><b>Results:</b> Two HbA1c trajectories with respect to differential CVD risk were identified: Low (HbA1c ~8% [64 mmol/mol] and improving over follow-up, 76% of cohort) and High (HbA1c ~10% [86 mmol/mol] and stable, 24%). Overall, 30-year CVD incidence was 47.4% (n=253); MACE incidence 31.0% (n=176). High HbA1c was associated with 3-fold increased CVD risk versus Low HbA1c. Both groups had similar age and diabetes duration. Non-HDLc and estimated glomerular filtration rate were associated with CVD risk only in Low HbA1c; albumin excretion rate was associated with CVD risk only in High HbA1c.<b> </b></p> <p><b>Conclusions: </b>These risk factor differences suggest that pathways to CVD may differ by glycemic control, potentially resulting in important implications for prognosis in type 1 diabetes.</p>

scholarly journals Response to Comment on Lacy et al. Long-term Glycemic Control and Dementia Risk in Type 1 Diabetes. Diabetes Care 2018;41:2339–2345

Diabetes Care ◽  
2019 ◽  
Vol 42 (4) ◽  
pp. e69-e69
Author(s):  
Mary E. Lacy ◽  
Paola Gilsanz ◽  
Andrew J. Karter ◽  
Charles P. Quesenberry ◽  
Mark J. Pletcher ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Diabetes Care ◽  
Dementia Risk

Initiation of insulin pump therapy in children at diagnosis of type 1 diabetes resulted in improved long-term glycemic control

2016 ◽  
Vol 18 (1) ◽  
pp. 26-32 ◽  
Author(s):  
Eunice G. Lang ◽  
Bruce R. King ◽  
Malcolm N. Miller ◽  
Sandra V. Dunn ◽  
Darrell A. Price ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Insulin Pump ◽  
Insulin Pump Therapy ◽  
Pump Therapy

scholarly journals Association of Glycemic Control in Type 1 Diabetes With Long-Term Risk After CABG

2015 ◽  
Vol 66 (24) ◽  
pp. 2809-2810
Author(s):  
Fu-Shan Xue ◽  
Rui-Ping Li ◽  
Gao-Pu Liu ◽  
Chao Sun
Keyword(s):  
Type 1 Diabetes ◽  
Glycemic Control
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