Quantification of the Therapeutic Response of Intraretinal, Subretinal, and Subpigment Epithelial Compartments in Exudative AMD during Anti-VEGF Therapy

2011 ◽  
Vol 52 (3) ◽  
pp. 1599 ◽  
Author(s):  
Isabelle Golbaz ◽  
Christian Ahlers ◽  
Geraldine Stock ◽  
Christopher Schütze ◽  
Sabine Schriefl ◽  
...  
Keyword(s):  
Therapeutic Response ◽  
Exudative Amd ◽  
Anti Vegf

scholarly journals Flavoprotein Fluorescence Correlation with Visual Acuity Response in Patients Receiving Anti-VEGF Injection for Diabetic Macular Edema

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Jorge S. Andrade Romo ◽  
Giselle Lynch ◽  
Kevin Liu ◽  
Daniel Kim ◽  
Michael Jansen ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Therapeutic Response ◽  
Diagnostic Methods ◽  
Fundus Photography ◽  
Additional Information ◽  
Structural Improvement ◽  
Anti Vegf ◽  
Patients With Diabetes

Anti-VEGF treatment of diabetic macular edema (DME) complicating diabetic retinopathy (DR) has greatly improved structural and visual outcomes for patients with diabetes mellitus. However, up to 50% of patients are either nonresponsive or refractory to anti-VEGF treatment (no improvement in BCVA or central macular thickness (CMT)). It is believed that factors such as mitochondrial structural and functional damage, due to oxidative stress, are partially responsible for this lack of improvement. Flavoprotein fluorescence (FPF) has been shown to be a sensitive marker of mitochondrial function and has been found to correlate with the degree of diabetic retinopathy. FPF may also provide additional information regarding therapeutic response of patients receiving anti-VEGF treatment for DME. Eight patients with DR and DME with clinically significant DME (CSDME) who underwent anti-VEGF (bevacizumab) treatment were imaged before injection and at follow-up visit using FPF in addition to standard color fundus photography and OCT CMT. A strong correlation r=0.98 (p=0.000015) between the FPF decrease and the BCVA improvement was observed; BCVA improved as FPF values decreased. Notably, in the same patients, the correlation between OCT CMT decrease and BCVA improvement (r=0.688) was not found to be significant (p=0.13). These findings suggest that FPF can detect improvement in metabolic function preceding structural improvement and even with small changes in edema. Additionally, FPF may be supplementary to current diagnostic methods for earlier detection of therapeutic response to anti-VEGF treatment in patients with DME.

Long-term visual course after anti-VEGF therapy for exudative AMD in clinical practice evaluation of the German reinjection scheme

2010 ◽  
Vol 249 (5) ◽  
pp. 639-644 ◽  
Author(s):  
Britta Heimes ◽  
Albrecht Lommatzsch ◽  
Meike Zeimer ◽  
Matthias Gutfleisch ◽  
Georg Spital ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Exudative Amd ◽  
Anti Vegf

Association of the CFH Y402H Polymorphism with the 1-Year Response of Exudative AMD to Intravitreal Anti-VEGF Treatment in the Brazilian Population

2017 ◽  
Vol 61 (3) ◽  
pp. 168-173 ◽  
Author(s):  
Flavio Mac Cord Medina ◽  
Augusto Alves Lopes da Motta ◽  
Walter Yukihiko Takahashi ◽  
Pedro Carlos Carricondo ◽  
Mario Martins dos Santos Motta ◽  
...  
Keyword(s):  
Brazilian Population ◽  
Exudative Amd ◽  
Anti Vegf ◽  
Y402h Polymorphism

scholarly journals Association between polymorphism rs11200638 in the HTRA1 gene and the response to anti-VEGF treatment of exudative AMD: a meta-analysis

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Ya-li Zhou ◽  
Chun-li Chen ◽  
Yi-xiao Wang ◽  
Yao Tong ◽  
Xiao-ling Fang ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Exudative Amd ◽  
Anti Vegf

Foveal RPE autofluorescence as a prognostic factor for anti-VEGF therapy in exudative AMD

2008 ◽  
Vol 246 (9) ◽  
pp. 1229-1234 ◽  
Author(s):  
Britta Heimes ◽  
Albrecht Lommatzsch ◽  
Meike Zeimer ◽  
Matthias Gutfleisch ◽  
Georg Spital ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Exudative Amd ◽  
Anti Vegf

scholarly journals Optical Coherence Tomography Angiography-Based Quantitative Assessment of Morphologic Changes in Active Myopic Choroidal Neovascularization During Anti-vascular Endothelial Growth Factor Therapy

2021 ◽  
Vol 8 ◽  
Author(s):  
Yao Wang ◽  
Zhongli Hu ◽  
Tiepei Zhu ◽  
Zhitao Su ◽  
Xiaoyun Fang ◽  
...  
Keyword(s):  
Fractal Dimension ◽  
Optical Coherence Tomography Angiography ◽  
Therapeutic Response ◽  
Vessel Diameter ◽  
Vascular Endothelial ◽  
Vessel Length ◽  
Vessel Area ◽  
Anti Vegf ◽  
Endothelial Growth Factor ◽  
Morphologic Changes

Purpose: To establish quantitative profile of the morphologic changes among patients with active myopic choroidal neovascularization (mCNV) before and after anti-vascular endothelial growth factor (VEGF) therapy using optical coherence tomography angiography (OCTA) to assess the therapeutic response.Methods: Patients with active mCNV who received anti-VEGF injections between February 2017 to October 2020 and fit the study criteria were retrospectively reviewed. Quantitative analysis of their OCTA images were carried out to evaluate the morphologic features and vascular changes of mCNV lesions in response to anti-VEGF therapy. For further quantitative profiling, mCNV area, fractal dimension, vessel area, vessel density, vessel diameter, vessel length, vessel junction, junction density, and vessel tortuosity were obtained by means of advanced skeletonization postprocessing analyses.Results: Thirty-one eyes of 29 consecutive patients with OCTA-positive mCNV lesions (mean spherical equivalent: −12.55 ± 3.24 diopters) were included. The 31 cases were divided into two phenotypes at baseline: organized interlacing pattern (83.87%) and disorganized vascular loops pattern (16.13%). The values of mCNV area, fractal dimension, vessel area, vessel length, vessel junction, and junction density decreased remarkably 1 month after the initial anti-VEGF injection (p < 0.001). Although, vessel density, vessel diameter, and vessel tortuosity increased meanwhile, only vessel diameter displayed statistical significance (p = 0.027). Of note, relative ratio analysis showed that vessel junction was the most sensitive biomarker in response to anti-VEGF therapy, reflecting a mean decrease of 50.36%. Sensitivity lowered successively in biomarkers of vessel length, vessel area, junction density, mCNV area, and fractal dimension. In addition, percent change of mCNV area (r = 0.552, p = 0.002), fractal dimension (r = 0.446, p = 0.017), vessel area (r = 0.518, p = 0.005), and vessel length (r = 0.440, p = 0.019) were moderately associated with that of central retinal thickness.Conclusions: The study showed morphological as well as quantitative changes on OCTA responding to anti-VEGF treatment in mCNV patients, among which vessel junctions might be the most predictive biomarker. OCTA-based analysis, providing intuitive images and a large spectrum of quantitative data at the same time, could promote new insights into the therapeutic response assessment in mCNV patients.

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