C-reactive Protein, Body Mass Index, and Diabetic Retinopathy

2010 ◽  
Vol 51 (9) ◽  
pp. 4458 ◽  
Author(s):  
Laurence Shen Lim ◽  
E. Shyong Tai ◽  
Paul Mitchell ◽  
Jie Jin Wang ◽  
Wan Ting Tay ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Diabetic Retinopathy ◽  
Body Mass ◽  
Protein Body ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals C-Reactive Protein and Body Mass Index in Patients with Type -2 Diabetes Mellitus and Diabetic Retinopathy

2013 ◽  
Vol 20 (2) ◽  
pp. 127-133
Author(s):  
Valeria Mocanu ◽  
Romulus Timar ◽  
Raluca Horhat ◽  
Adina Bucur ◽  
Viorel Şerban
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Body Mass Index ◽  
Diabetic Retinopathy ◽  
Body Mass ◽  
The Body ◽  
Fundus Examination ◽  
C Reactive Protein ◽  
Reactive Protein

AbstractBackground and aims: C-reactive protein (CRP) is an inflammatory biomarker that may be associated with diabetic retinopathy (DR). The body mass index (BMI) is an important element, frequently evaluated in patients with diabetes mellitus. The purpose of this study was to determine the relationship between CRP, BMI and existing DR in type 2 diabetes (T2DM) subjects. Material and method: Thirty T2DM patients aged 35-50 were subjected to a general, ophthalmologic and fundus examination. Results: 9 of the 30 patients (30%) didn’t presented changes in the fundus examination. 15 (50%) presented minor retinal changes while 6 (20%) were diagnosed with DR: one case of nonproliferative diabetic retinopathy, 2 cases of preproliferative DR and 3 cases of proliferative DR. In patients with normal fundus examination and minor retinal changes, CRP was positive in the majority of the cases (95.8%). CRP was positive in only one patient in the group with diagnosed DR. BMI was increased in 85.71% of the patients with retinal changes: angiosclerosis or DR and in only 22.22% of the patients without retinal changes. Conclusions: Lower CRP and higher BMI were associated with higher prevalence of DR.

Body Mass Index, but Not Physical Activity, Is Associated with C-Reactive Protein

2003 ◽  
Vol 35 (7) ◽  
pp. 1160-1166 ◽  
Author(s):  
ERIC S. RAWSON ◽  
PATTY S. FREEDSON ◽  
STAVROULA K. OSGANIAN ◽  
CHARLES E. MATTHEWS ◽  
GEORGE REED ◽  
...  
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Body Mass ◽  
C Reactive Protein ◽  
Reactive Protein

Serum C reactive protein levels and genetic variation in the CRP gene are not associated with the prevalence, incidence or progression of osteoarthritis independent of body mass index

2010 ◽  
Vol 69 (11) ◽  
pp. 1976-1982 ◽  
Author(s):  
Hanneke J M Kerkhof ◽  
Sita M A Bierma-Zeinstra ◽  
Martha C Castano-Betancourt ◽  
Moniek P de Maat ◽  
Albert Hofman ◽  
...  
Keyword(s):  
Systematic Review ◽  
Body Mass Index ◽  
Genetic Variation ◽  
Body Mass ◽  
Analysis Of Covariance ◽  
C Reactive Protein ◽  
Knee Oa ◽  
Reactive Protein ◽  
Serum Crp ◽  
The Relationship

ObjectiveTo study the relationship between serum C reactive protein (CRP) levels, genetic variation in the CRP gene and the prevalence, incidence and progression of radiographic osteoarthritis (ROA) in the Rotterdam Study-I (RS-I). A systematic review of studies assessing the relationship between osteoarthritis (OA) and CRP levels was also performed.MethodsThe association between CRP levels and genetic variation in the CRP gene and ROA was examined in 861 patients with hand OA, 718 with knee OA, 349 with hip OA and 2806 controls in the RS-I using one-way analysis of covariance and logistic regression, respectively. PubMed was searched for articles published between January 1992 and August 2009 assessing the relationship between CRP levels and OA.ResultsIn RS-I the prevalence of knee OA, but not hip OA or hand OA, was associated with 14% higher serum CRP levels compared with controls (p=0.001). This association disappeared after adjustment for age and especially body mass index (BMI) (p=0.33). Genetic variation of the CRP gene was not consistently associated with the prevalence, incidence or progression of OA within RS-I. The systematic review included 18 studies (including RS-I) on serum CRP levels and the prevalence, incidence or progression of OA. Consistently higher crude CRP levels were found in cases of prevalent knee OA compared with controls. No association was observed between serum CRP levels and the prevalence of knee OA following adjustment for BMI (n=3 studies, meta-analysis p value=0.61).ConclusionThere is no evidence of association between serum CRP levels or genetic variation in the CRP gene with the prevalence, incidence or progression of OA independent of BMI.

scholarly journals The Metabolic Phenotype of Prader-Willi Syndrome (PWS) in Childhood: Heightened Insulin Sensitivity Relative to Body Mass Index

2011 ◽  
Vol 96 (1) ◽  
pp. E225-E232 ◽  
Author(s):  
Andrea M. Haqq ◽  
Michael J. Muehlbauer ◽  
Christopher B. Newgard ◽  
Steven Grambow ◽  
Michael Freemark
Keyword(s):  
Body Mass Index ◽  
Insulin Sensitivity ◽  
Body Mass ◽  
Density Lipoprotein ◽  
High Sensitivity ◽  
Metabolic Phenotype ◽  
Prader Willi Syndrome ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Total Adiponectin

Context: Insulin sensitivity is higher in patients with Prader-Willi syndrome (PWS) than in body mass index-matched obese controls (OCs). Factors contributing to the heightened insulin sensitivity of PWS remain obscure. We compared the fasting levels of various hormones, cytokines, lipids, and liver function tests in 14 PWS patients and 14 OCs with those in 14 age- and gender-matched lean children (LC). We hypothesized that metabolic profiles of children with PWS are comparable with those of LC, but different from those of OCs. Results: Leptin levels were comparable in PWS patients and OCs, suggesting comparable degrees of adiposity. Glucose levels were comparable among groups. However, fasting insulin concentrations and homeostasis model assessment insulin resistance index were lower in PWS patients than in OCs (P < 0.05) and similar to LC. Moreover, high-density lipoprotein levels were lower and triglycerides higher in OCs (P < 0.05) but not PWS patients. Total adiponectin, high-molecular-weight (HMW) adiponectin and the HMW to total adiponectin ratio were higher in PWS patients (P < 0.05) than in OCs and similar to LC. High-sensitivity C-reactive protein and IL-6 levels were higher in OCs than in PWS patients or LC (P < 0.05). Nevertheless, PAI-1 levels were elevated in both OC and PWS patients. There were no group differences in glucagon-like peptide-1, macrophage chemoattractant protein-1, TNFα, IL-2, IL-8, IL-10, IL-12p40, IL-18, resistin, total or low-density lipoprotein cholesterol, aspartate aminotransferase, or alanine aminotransferase. Conclusions: The heightened insulin sensitivity of PWS patients relative to OCs is associated with higher levels of adiponectin and lower levels of high-sensitivity C-reactive protein and IL-6. Future studies will determine whether PWS children are protected from obesity comorbidities such as type 2 diabetes, hyperlipidemia, and nonalcoholic fatty liver disease.

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