scholarly journals Dynamic Patterns of Histone Lysine Methylation in the Developing Retina

2010 ◽  
Vol 51 (12) ◽  
pp. 6784 ◽  
Author(s):  
Rajesh C. Rao ◽  
Kissaou T. Tchedre ◽  
Muhammad Taimur A. Malik ◽  
Natasha Coleman ◽  
Yuan Fang ◽  
...  
Keyword(s):  
Lysine Methylation ◽  
Histone Lysine Methylation ◽  
Histone Lysine ◽  
Dynamic Patterns

The Indexing Potential of Histone Lysine Methylation

2008 ◽  
pp. 22-47 ◽  
Author(s):  
Gunnar Schotta ◽  
Monika Lachner ◽  
Antoine H. F. M. Peters ◽  
Thomas Jenuwein
Keyword(s):  
Lysine Methylation ◽  
Histone Lysine Methylation ◽  
Histone Lysine

scholarly journals Protein lysine 43 methylation by EZH1 promotes AML1-ETO transcriptional repression in leukemia

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Liping Dou ◽  
Fei Yan ◽  
Jiuxia Pang ◽  
Dehua Zheng ◽  
Dandan Li ◽  
...  
Keyword(s):  
Dna Sequences ◽  
Transcriptional Repression ◽  
Lysine Methylation ◽  
Post Translational Modification ◽  
Histone Lysine Methylation ◽  
Histone Lysine ◽  
Histone Lysine Methyltransferase ◽  
Lysine Methyltransferase

Abstract The oncogenic fusion protein AML1-ETO retains the ability of AML1 to interact with the enhancer core DNA sequences, but blocks AML1-dependent transcription. Previous studies have shown that post-translational modification of AML1-ETO may play a role in its regulation. Here we report that AML1-ETO-positive patients, with high histone lysine methyltransferase Enhancer of zeste homolog 1 (EZH1) expression, show a worse overall survival than those with lower EZH1 expression. EZH1 knockdown impairs survival and proliferation of AML1-ETO-expressing cells in vitro and in vivo. We find that EZH1 WD domain binds to the AML1-ETO NHR1 domain and methylates AML1-ETO at lysine 43 (Lys43). This requires the EZH1 SET domain, which augments AML1-ETO-dependent repression of tumor suppressor genes. Loss of Lys43 methylation by point mutation or domain deletion impairs AML1-ETO-repressive activity. These findings highlight the role of EZH1 in non-histone lysine methylation, indicating that cooperation between AML1-ETO and EZH1 and AML1-ETO site-specific lysine methylation promote AML1-ETO transcriptional repression in leukemia.

Histone lysine methylation exhibits a distinct distribution during spermatogenesis in pigs

2015 ◽  
Vol 84 (9) ◽  
pp. 1455-1462 ◽  
Author(s):  
Junhui An ◽  
Jinzhou Qin ◽  
Yi Wan ◽  
Yaqing Zhang ◽  
Yuan Hu ◽  
...  
Keyword(s):  
Lysine Methylation ◽  
Histone Lysine Methylation ◽  
Histone Lysine ◽  
Distinct Distribution

Impacts of Histone Lysine Methylation on Chromatin

2016 ◽  
pp. 25-53
Author(s):  
S. Lanouette ◽  
J. Haddad ◽  
P. Zhang ◽  
J.-F. Couture
Keyword(s):  
Lysine Methylation ◽  
Histone Lysine Methylation ◽  
Histone Lysine

scholarly journals A Crack in Histone Lysine Methylation

Cell ◽  
2004 ◽  
Vol 119 (7) ◽  
pp. 903-906 ◽  
Author(s):  
Stefan Kubicek ◽  
Thomas Jenuwein
Keyword(s):  
Lysine Methylation ◽  
Histone Lysine Methylation ◽  
Histone Lysine
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