Effect of Anterior Chamber Depth on Shear Stress Exerted on Corneal Endothelial Cells by Altered Aqueous Flow after Laser Iridotomy

2010 ◽  
Vol 51 (4) ◽  
pp. 1956 ◽  
Author(s):  
Yasuaki Yamamoto ◽  
Toshihiko Uno ◽  
Takeshi Joko ◽  
Atsushi Shiraishi ◽  
Yuichi Ohashi
Keyword(s):  
Endothelial Cells ◽  
Shear Stress ◽  
Anterior Chamber ◽  
Anterior Chamber Depth ◽  
Corneal Endothelial Cells ◽  
Laser Iridotomy ◽  
Aqueous Flow

Central Anterior Chamber Depth Changes After Prophylactic Laser Iridotomy

2013 ◽  
Vol 90 (7) ◽  
pp. 707-710 ◽  
Author(s):  
Amir Faramarzi ◽  
Shahin Yazdani ◽  
Mohammad Pakravan
Keyword(s):  
Anterior Chamber ◽  
Anterior Chamber Depth ◽  
Laser Iridotomy

The effects of proinflammatory cytokines on the apoptosis of corneal endothelial cells following argon laser iridotomy

2016 ◽  
Vol 145 ◽  
pp. 140-147 ◽  
Author(s):  
Youngsub Eom ◽  
Junki Kwon ◽  
Jeong-Hwa Heo ◽  
Cheolmin Yun ◽  
Su-Yeon Kang ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Proinflammatory Cytokines ◽  
Argon Laser ◽  
Corneal Endothelial Cells ◽  
Laser Iridotomy

scholarly journals Long-Term Destiny of Corneal Endothelial Cells in Anterior Chamber Intraocular Lens-Implanted Eyes

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Yating Tang ◽  
Jie Xu ◽  
Jiahui Chen ◽  
Yi Lu
Keyword(s):  
Endothelial Cells ◽  
Endothelial Cell ◽  
Anterior Chamber ◽  
Cell Density ◽  
Intraocular Lens ◽  
Corneal Endothelial Cells ◽  
Corneal Decompensation ◽  
The Mean

Purpose. To investigate the long-term changes of corneal endothelial cells (EC) in anterior chamber intraocular lens- (AC-IOL-) implanted eyes. Methods. Retrospective study. We included 37 eyes (25 patients) that received AC-IOL implantation previously in the Eye and ENT Hospital of Fudan University between 1995 and 2016. Follow-up outcomes included the best-corrected visual acuity (BCVA), endothelial cell density, hexagonality, coefficient of variance, and central corneal thickness. Results. In total, 23 eyes (62.16%) with phakic and 14 eyes (37.84%) with aphakic AC-IOLs were included. Among these, 3 eyes (8.11%) were angle-supported AC-IOLs and 34 eyes (91.89%) were Artisan iris-fixated AC-IOLs. The mean age of patients was 41.40 ± 17.17 years, and the mean follow-up time was 12.12 ± 4.71 years in our study. At the follow-up time, corneal decompensation existed in 3 angle-supported AC-IOL eyes with a rate of 100% and 15 iris-fixated AC-IOL eyes with a rate of 44.12%. AC-IOL displacement occurred in 14 (41.18%) iris-fixated AC-IOL eyes. In the 19 iris-fixated AC-IOL eyes without corneal decompensation, significant changes also took place in corneal endothelial cells. The endothelial cell density decreased from 2843.26 ± 300.76 to 2015.58 ± 567.99 cells/mm2 (29.1% loss, P < 0.001 ) and hexagonality decreased from 51.21 ± 7.83 to 42.53 ± 9.17 (%) (16.9% loss, P < 0.001 ). The Kaplan–Meier survival curve also demonstrated the accumulated expectation rates of corneal endothelial cell decomposition for AC-IOLs with a median survival time of 12 years. Conclusion. We reported a significant chronic loss and long-term decompensation destiny of corneal endothelial cells in AC-IOL eyes. Semiannual or annual follow-up and evaluation of endothelial cells should be conducted in AC-IOL-implanted patients.

scholarly journals Comparison of the Changes in Corneal Endothelial Cells after Pars Plana and Anterior Chamber Ahmed Valve Implant

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Ji Won Seo ◽  
Jong Yeon Lee ◽  
Dong Heun Nam ◽  
Dae Yeong Lee
Keyword(s):  
Endothelial Cells ◽  
Endothelial Cell ◽  
Anterior Chamber ◽  
Cell Damage ◽  
Corneal Endothelial Cells ◽  
Refractory Glaucoma ◽  
Endothelial Cell Damage ◽  
Significant Difference ◽  
Pars Plana

Purpose. To compare the changes in corneal endothelial cells after pars plana Ahmed glaucoma valve (AGV) implantation with those after the anterior chamber AGV implantation for refractory glaucoma.Methods. The medical records of 18 eyes with pars plana implantation of AGV (ppAGV) were reviewed retrospectively and were compared with 18 eyes with the anterior chamber AGV (acAGV) implant. The preoperative and postoperative endothelial cells, intraocular pressure (IOP), and postoperative complications during the follow-up in both groups were compared.Results. The average follow-up was 18 months. The postoperative endothelial cells in the ppAGV and acAGV groups were 2044 ± 303 and 1904 ± 324, respectively(P=0.25). The average percentage decrease in the endothelial cells in the ppAGV and acAGV groups at 18 months was 12.5% and 18.4%, respectively, and showed significant difference between the 2 groups(P=0.01). No difference in IOP control and the number of postoperative glaucoma medications was observed between the 2 groups.Conclusions. Endothelial cell damage in the ppAGV group for refractory glaucoma appeared to be lower than that in the acAGV group. Therefore, pars plana implantation of AGV may be preferred as it may have lower level of endothelial cell damage while maintaining similar level of IOP control.

scholarly journals Early Postoperative Effects of Uncomplicated Phacoemulsification Surgery on Corneal Endothelial Cells and Thickness in Patients with Pseudoexfoliation Syndrome

2021 ◽  
Author(s):  
EREN EKİCİ ◽  
Ali Keles ◽  
Süleyman Korhan Kahraman
Keyword(s):  
Endothelial Cells ◽  
Anterior Chamber ◽  
Coefficient Of Variation ◽  
Corneal Edema ◽  
Pseudoexfoliation Syndrome ◽  
Cell Area ◽  
Corneal Endothelial Cells ◽  
Hexagonal Cell ◽  
Significant Group ◽  
Cell Ratio

Abstract Purpose: To compare early postoperative effects of uncomplicated phacoemulsification surgery on corneal endothelial cells and thickness in patients with pseudoexfoliation syndrome (PEX).Methods: One eye each of 32 patients with PEX and 32 age-matched non-PEX subjects was evaluated preoperatively and on 1st, 7th, and 30th days after uncomplicated phacoemulsification surgery in this retrospective case-control study. Nuclear firmness, corneal edema (CE), anterior chamber reaction (ACR) intensity were graded by a slit-lamp microscope. Endothelial cell density (ECD), coefficient of variation in cell area (CV), hexagonal cell ratio (HEX), and central corneal thickness (CCT) were measured using a noncontact specular microscope.Results: There was no significant group-difference in age, sex, corneal edema (CE), anterior chamber reaction (ACR), coefficient of variation in cell area (CV), and hexagonal cell ratio (HEX). Mean effective phaco time (EPT) was significantly lower intraoperatively (p<0.001) and logarithm of the minimum angle of resolution (logMAR) values of best-corrected visual acuity (BCVA) were significantly higher on both 1st (p<0.001), 7th (p=0.011), and 30th (p=0.025) days postoperatively in the PEX group than in the non-PEX group. Mean ECD was significantly lower in the PEX group than in the non-PEX group on 7th (p=0.013), and 30th (p=0.037) days postoperatively. The mean CCT significantly differed only on 1st (p<0.001) day postoperatively.Conclusion: Eyes with PEX presented lower corneal ECD and decreased BCVA after uncomplicated phacoemulsification surgery. Further, there was no association between CCT and PEX existence preoperatively and in the early postoperative period.

scholarly journals The Response of Corneal Endothelial Cells to Shear Stress in an In Vitro Flow Model

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Sujuan Duan ◽  
Yingjie Li ◽  
Yanyan Zhang ◽  
Xuan Zhu ◽  
Yan Mei ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Shear Stress ◽  
Fluid Flow ◽  
Corneal Endothelium ◽  
Aqueous Humour ◽  
Fluid Shear Stress ◽  
Corneal Endothelial Cells ◽  
Fluid Shear ◽  
Endothelial Cell Function

Purpose. Corneal endothelial cells are usually exposed to shear stress caused by the aqueous humour, which is similar to the exposure of vascular endothelial cells to shear stress caused by blood flow. However, the effect of fluid shear stress on corneal endothelial cells is still poorly understood. The purpose of this study was to explore whether the shear stress that results from the aqueous humour influences corneal endothelial cells. Methods. An in vitro model was established to generate fluid flow on cells, and the effect of fluid flow on corneal endothelial cells after exposure to two levels of shear stress for different durations was investigated. The mRNA and protein expression of corneal endothelium-related markers in rabbit corneal endothelial cells was evaluated by real-time PCR and western blotting. Results. The expression of the corneal endothelium-related markers ZO-1, N-cadherin, and Na+-K+-ATPase in rabbit corneal endothelial cells (RCECs) was upregulated at both the mRNA and protein levels after exposure to shear stress. Conclusion. This study demonstrates that RCECs respond favourably to fluid shear stress, which may contribute to the maintenance of corneal endothelial cell function. Furthermore, this study also provides a theoretical foundation for further investigating the response of human corneal endothelial cells to the shear stress caused by the aqueous humour.

Investigation of Saccadic Eye Movement Effects on the Fluid Dynamic in the Anterior Chamber

2012 ◽  
Vol 134 (2) ◽  
Author(s):  
Omid Abouali ◽  
Amirreza Modareszadeh ◽  
Alireza Ghaffarieh ◽  
Jiyuan Tu
Keyword(s):  
Shear Stress ◽  
Flow Field ◽  
Anterior Chamber ◽  
Fluid Dynamic ◽  
Analytic Solutions ◽  
Navier Stokes ◽  
Corneal Endothelial Cells ◽  
Saccadic Movement ◽  
Energy Equations ◽  
Mesh Technique

The aqueous humor (AH) flow in the anterior chamber (AC) due to saccadic movements is investigated in this research. The continuity, Navier-Stokes and energy equations in 3D and unsteady forms are solved numerically and the saccadic motion was modeled by the dynamic mesh technique. Firstly, the numerical model was validated for the saccadic movement of a spherical cavity with analytic solutions and experimental data where excellent agreement was observed. Then, two types of periodic and realistic saccadic motions of the AC are simulated, whereby the flow field is computed for various saccade amplitudes and the results are reported for different times. The results show that the acting shear stress on the corneal endothelial cells from AH due to saccadic movements is much higher than that due to normal AH flow by buoyancy induced due to temperature gradient. This shear stress is higher on the central region of the cornea. The results also depict that eye saccade imposes a 3D complicated flow field in the AC consist of various vortex structures. Finally, the enchantment of heat transfer in the AC by AH mixing as a result of saccadic motion is investigated.

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