scholarly journals Integrin α5β1 Mediates Attachment, Migration, and Proliferation in Human Retinal Pigment Epithelium: Relevance for Proliferative Retinal Disease

2009 ◽  
Vol 50 (12) ◽  
pp. 5988 ◽  
Author(s):  
Rong Li ◽  
Arvydas Maminishkis ◽  
Grit Zahn ◽  
Doerte Vossmeyer ◽  
Sheldon S. Miller
Keyword(s):  
Retinal Pigment Epithelium ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Retinal Disease ◽  
Integrin Α5β1 ◽  
Human Retinal Pigment Epithelium

scholarly journals MCP-1–Activated Monocytes Induce Apoptosis in Human Retinal Pigment Epithelium

2011 ◽  
Vol 52 (8) ◽  
pp. 6026 ◽  
Author(s):  
Dongli Yang ◽  
Susan G. Elner ◽  
Xun Chen ◽  
Matthew G. Field ◽  
Howard R. Petty ◽  
...  
Keyword(s):  
Retinal Pigment Epithelium ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Human Retinal Pigment Epithelium ◽  
Activated Monocytes

scholarly journals Determination of N-retinylidene-N-retinylethanolamine (A2E) levels in central and peripheral areas of human retinal pigment epithelium

2015 ◽  
Vol 14 (11) ◽  
pp. 1983-1990 ◽  
Author(s):  
Leopold Adler ◽  
Nicholas P. Boyer ◽  
David M. Anderson ◽  
Jeffrey M. Spraggins ◽  
Kevin L. Schey ◽  
...  
Keyword(s):  
Retinal Pigment Epithelium ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Central Area ◽  
Human Retinal Pigment Epithelium ◽  
Peripheral Areas

The levels of the bis-retinoid A2E cannot account for the high levels of lipofuscin fluorescence found in the central area of the human retinal pigment epithelium.

scholarly journals Loss of melanoregulin (MREG) enhances cathepsin-D secretion by the retinal pigment epithelium

2013 ◽  
Vol 30 (3) ◽  
pp. 55-64 ◽  
Author(s):  
LAURA S. FROST ◽  
VANDA S. LOPES ◽  
FRANK P. STEFANO ◽  
ALVINA BRAGIN ◽  
DAVID S. WILLIAMS ◽  
...  
Keyword(s):  
Retinal Pigment Epithelium ◽  
Cathepsin D ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Retinal Disease ◽  
Protective Role ◽  
Phagocytic Cells ◽  
Phagocytic Capacity ◽  
Photoreceptor Outer Segments ◽  
Age Dependent

AbstractCathepsin-D (Cat-D) is a major proteolytic enzyme in phagocytic cells. In the retinal pigment epithelium (RPE), it is responsible for the daily degradation of photoreceptor outer segments (POSs) to maintain retinal homeostasis. Melanoregulin (MREG)-mediated loss of phagocytic capacity has been linked to diminished intracellular Cat-D activity. Here, we demonstrate that loss of MREG enhances the secretion of intermediate Cat-D (48 kDa), resulting in a net enhancement of extracellular Cat-D activity. These results suggest that MREG is required to maintain Cat-D homeostasis in the RPE and likely plays a protective role in retinal health. In this regard, in the Mregdsu/dsu mouse, we observe increased basal laminin. Loss of the Mregdsu allele is not lethal and therefore leads to slow age-dependent changes in the RPE. Thus, we propose that this model will allow us to study potential dysregulatory functions of Cat-D in retinal disease.

Opticin production is reduced by hypoxia and VEGF in human retinal pigment epithelium via MMP-2 activation

Cytokine ◽  
2012 ◽  
Vol 59 (1) ◽  
pp. 100-107 ◽  
Author(s):  
Jin Ma ◽  
Tie Pei Zhu ◽  
Morten C. Moe ◽  
Panpan Ye ◽  
Ke Yao
Keyword(s):  
Retinal Pigment Epithelium ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Human Retinal Pigment Epithelium

scholarly journals CNTF Mediates Neurotrophic Factor Secretion and Fluid Absorption in Human Retinal Pigment Epithelium

PLoS ONE ◽  
2011 ◽  
Vol 6 (9) ◽  
pp. e23148 ◽  
Author(s):  
Rong Li ◽  
Rong Wen ◽  
Tina Banzon ◽  
Arvydas Maminishkis ◽  
Sheldon S. Miller
Keyword(s):  
Retinal Pigment Epithelium ◽  
Neurotrophic Factor ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Fluid Absorption ◽  
Human Retinal Pigment Epithelium ◽  
Factor Secretion
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