scholarly journals Increased Synthesis of Leukotrienes in the Mouse Model of Diabetic Retinopathy

2010 ◽  
Vol 51 (3) ◽  
pp. 1699 ◽  
Author(s):  
Ramaprasad Talahalli ◽  
Simona Zarini ◽  
Nader Sheibani ◽  
Robert C. Murphy ◽  
Rose A. Gubitosi-Klug
Keyword(s):  
Diabetic Retinopathy ◽  
Mouse Model

scholarly journals Role of endoplasmic reticulum stress in 12/15-lipoxygenase-induced retinal microvascular dysfunction in a mouse model of diabetic retinopathy

Diabetologia ◽  
2018 ◽  
Vol 61 (5) ◽  
pp. 1220-1232 ◽  
Author(s):  
Khaled Elmasry ◽  
Ahmed S. Ibrahim ◽  
Heba Saleh ◽  
Nehal Elsherbiny ◽  
Sally Elshafey ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Diabetic Retinopathy ◽  
Endoplasmic Reticulum Stress ◽  
Mouse Model ◽  
Microvascular Dysfunction

Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy

Science ◽  
2020 ◽  
Vol 369 (6506) ◽  
pp. eaay5356
Author(s):  
François Binet ◽  
Gael Cagnone ◽  
Sergio Crespo-Garcia ◽  
Masayuki Hata ◽  
Mathieu Neault ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Diabetic Retinopathy ◽  
Mouse Model ◽  
Vascular Remodeling ◽  
Neutrophil Extracellular Traps ◽  
Developed Countries ◽  
Sterile Inflammation ◽  
Extracellular Traps ◽  
Retinal Blood Vessels ◽  
Underlying Mechanisms

In developed countries, the leading causes of blindness such as diabetic retinopathy are characterized by disorganized vasculature that can become fibrotic. Although many such pathological vessels often naturally regress and spare sight-threatening complications, the underlying mechanisms remain unknown. Here, we used orthogonal approaches in human patients with proliferative diabetic retinopathy and a mouse model of ischemic retinopathies to identify an unconventional role for neutrophils in vascular remodeling during late-stage sterile inflammation. Senescent vasculature released a secretome that attracted neutrophils and triggered the production of neutrophil extracellular traps (NETs). NETs ultimately cleared diseased endothelial cells and remodeled unhealthy vessels. Genetic or pharmacological inhibition of NETosis prevented the regression of senescent vessels and prolonged disease. Thus, clearance of senescent retinal blood vessels leads to reparative vascular remodeling.

scholarly journals Basigin can be a therapeutic target to restore the retinal vascular barrier function in the mouse model of diabetic retinopathy

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Mitsuru Arima ◽  
Dan Cui ◽  
Tokuhiro Kimura ◽  
Koh-Hei Sonoda ◽  
Tatsuro Ishibashi ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Mouse Model ◽  
Therapeutic Target ◽  
Barrier Function

scholarly journals Oxidative Stress and Light-Evoked Responses of the Posterior Segment in a Mouse Model of Diabetic Retinopathy

2015 ◽  
Vol 56 (1) ◽  
pp. 606-615 ◽  
Author(s):  
B. A. Berkowitz ◽  
E. M. Grady ◽  
N. Khetarpal ◽  
A. Patel ◽  
R. Roberts
Keyword(s):  
Oxidative Stress ◽  
Diabetic Retinopathy ◽  
Mouse Model ◽  
Posterior Segment ◽  
Evoked Responses

scholarly journals 5-Lipoxygenase, but Not 12/15-Lipoxygenase, Contributes to Degeneration of Retinal Capillaries in a Mouse Model of Diabetic Retinopathy

Diabetes ◽  
2008 ◽  
Vol 57 (5) ◽  
pp. 1387-1393 ◽  
Author(s):  
R. A. Gubitosi-Klug ◽  
R. Talahalli ◽  
Y. Du ◽  
J. L. Nadler ◽  
T. S. Kern
Keyword(s):  
Diabetic Retinopathy ◽  
Mouse Model ◽  
Retinal Capillaries

scholarly journals Interleukin-6 trans-signaling inhibition prevents oxidative stress in a mouse model of early diabetic retinopathy

Redox Biology ◽  
2020 ◽  
Vol 34 ◽  
pp. 101574 ◽  
Author(s):  
Rebekah Robinson ◽  
Mukund Srinivasan ◽  
Arul Shanmugam ◽  
Alexander Ward ◽  
Veena Ganapathy ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetic Retinopathy ◽  
Mouse Model ◽  
Interleukin 6

scholarly journals Immunohistochemical Characterization of Connexin43 Expression in a Mouse Model of Diabetic Retinopathy and in Human Donor Retinas

2017 ◽  
Vol 18 (12) ◽  
pp. 2567 ◽  
Author(s):  
Odunayo Mugisho ◽  
Colin Green ◽  
Jie Zhang ◽  
Nicolette Binz ◽  
Monica Acosta ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Mouse Model ◽  
Human Donor

scholarly journals Clock Genes and Behavioral Responses to Light Are Altered in a Mouse Model of Diabetic Retinopathy

PLoS ONE ◽  
2014 ◽  
Vol 9 (7) ◽  
pp. e101584 ◽  
Author(s):  
Hasna Lahouaoui ◽  
Christine Coutanson ◽  
Howard M. Cooper ◽  
Mohamed Bennis ◽  
Ouria Dkhissi-Benyahya
Keyword(s):  
Diabetic Retinopathy ◽  
Mouse Model ◽  
Clock Genes ◽  
Behavioral Responses

Construction of Hyaluronic Acid-CeO2 Conjugated Composite Nanoparticles and Their Activity Efficiency in Diabetic Retinopathy Alleviation

2021 ◽  
Vol 17 (11) ◽  
pp. 2219-2225
Author(s):  
Jingzhi Shao ◽  
Jingjing Wan ◽  
Fengyan Zhang ◽  
Lirong Zhang
Keyword(s):  
Diabetic Retinopathy ◽  
Hyaluronic Acid ◽  
Mouse Model ◽  
Clinical Efficacy ◽  
Structural Integrity ◽  
Foreign Body Reaction ◽  
Immune Cell ◽  
Cell Infiltration ◽  
Immune Cell Infiltration ◽  
Retinal Structure

We developed an effective nanoparticle-biomaterial in alleviating diabetic retinopathy (DR), hyaluronic acid (HA)-CeO2, composed mainly of CeO2 and HA. To demonstrate its anti-DR capacity, retinal cells from a B6/J mouse model were used to compare the efficiency of PEI-CeO2 and HA-CeO2. We investigated the transport performance, histolysis, immune cell infiltration, angiogenesis, and hyperemia induced by the transport system. The structural integrity, microvascular apoptosis, and superoxide and peroxide concentrations in the retina were measured to evaluate the clinical efficacy of CeO2. The infiltration efficiency of HA-CeO2 was higher than that of PEI-CeO2. Lower levels of foreign body reaction were evident for HA-CeO2 with less histolysis, immune cell infiltration, angiogenesis, and hyperemia. The clinical efficacy of HA-CeO2 in terms of preservation of retinal structure and lowering of microvascular apoptosis and superoxide and peroxide concentrations was superior to those of PEI-CP. HA-CeO2 was shown to have significant antioxidation and anti-vascular injury capacity in a mouse model, and may be a potential compound nanodrug for DR treatment in the future.

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