scholarly journals Prediction Model for Prevalence and Incidence of Advanced Age-Related Macular Degeneration Based on Genetic, Demographic, and Environmental Variables

2009 ◽  
Vol 50 (5) ◽  
pp. 2044 ◽  
Author(s):  
Johanna M. Seddon ◽  
Robyn Reynolds ◽  
Julian Maller ◽  
Jesen A. Fagerness ◽  
Mark J. Daly ◽  
...  
Keyword(s):  
Prediction Model ◽  
Macular Degeneration ◽  
Environmental Variables ◽  
Age Related Macular Degeneration ◽  
Advanced Age ◽  
Age Related

Major Predictive Factors for Progression of Early to Late Age-Related Macular Degeneration

2020 ◽  
Vol 243 (6) ◽  
pp. 444-452 ◽  
Author(s):  
Vasilena Sitnilska ◽  
Eveline Kersten ◽  
Lebriz Altay ◽  
Tina Schick ◽  
Philip Enders ◽  
...  
Keyword(s):  
Prediction Model ◽  
Macular Degeneration ◽  
Area Under The Curve ◽  
Age Related Macular Degeneration ◽  
Advanced Age ◽  
Fundus Photography ◽  
Imaging Biomarkers ◽  
Nucleotide Polymorphisms ◽  
Phenotypic Profile ◽  
Age Related

<b><i>Introduction:</i></b> We present a prediction model for progression from early/intermediate to advanced age-related macular degeneration (AMD) within 5.9 years. <b><i>Objectives:</i></b> To evaluate the combined role of genetic, nongenetic, and phenotypic risk factors for conversion from early to late AMD over ≥5 years. <b><i>Methods:</i></b> Baseline phenotypic characteristics were evaluated based on color fundus photography, spectral-domain optical coherence tomography, and infrared images. Genotyping for 36 single-nucleotide polymorphisms as well as systemic lipid and complement measurements were performed. Multivariable backward logistic regression resulted in a final prediction model. <b><i>Results and Conclusions:</i></b> During a mean of 5.9 years of follow-up, 22.4% (<i>n</i> = 52) of the patients (<i>n</i> = 232) showed progression to late AMD. The multivariable prediction model included age, <i>CFH</i> variant rs1061170, pigment abnormalities, drusenoid pigment epithelial detachment (DPED), and hyperreflective foci (HRF). The model showed an area under the curve of 0.969 (95% confidence interval 0.948–0.990) and adequate calibration (Hosmer-Lemeshow test, <i>p</i> = 0.797). In addition to advanced age and carrying a <i>CFH</i> variant, pigment abnormalities, DPED, and HRF are relevant imaging biomarkers for conversion to late AMD. In clinical routine, an intensified monitoring of patients with a high-risk phenotypic profile may be suitable for the early detection of conversion to late AMD.

INVESTIGATING A GROWTH PREDICTION MODEL IN ADVANCED AGE-RELATED MACULAR DEGENERATION WITH SOLITARY GEOGRAPHIC ATROPHY USING QUANTITATIVE AUTOFLUORESCENCE

Retina ◽  
2020 ◽  
Vol 40 (9) ◽  
pp. 1657-1664 ◽  
Author(s):  
Gregor S. Reiter ◽  
Reinhard Told ◽  
Lukas Baumann ◽  
Stefan Sacu ◽  
Ursula Schmidt-Erfurth ◽  
...  
Keyword(s):  
Prediction Model ◽  
Macular Degeneration ◽  
Geographic Atrophy ◽  
Age Related Macular Degeneration ◽  
Advanced Age ◽  
Growth Prediction ◽  
Age Related

scholarly journals Outer retinal tubulation formation and clinical course of advanced age-related macular degeneration

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Alessandro Arrigo ◽  
Emanuela Aragona ◽  
Ottavia Battaglia ◽  
Andrea Saladino ◽  
Alessia Amato ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Müller Cells ◽  
Geographic Atrophy ◽  
Age Related Macular Degeneration ◽  
Advanced Age ◽  
Age Related ◽  
Dry Amd ◽  
Foveal Sparing ◽  
Wet Amd

AbstractOuter retinal tubulations (ORT) are a relatively new finding characterizing outer retinal atrophy. The main aim of the present study was to describe ORT development in advanced age-related macular degeneration (AMD) and to assess its relationship with disease’s severity. Patients with advanced AMD characterized either by macular neovascularization or geographic atrophy, showing signs of outer retinal disruption or retinal pigment epithelium atrophy on structural optical coherence tomography (OCT) at the inclusion examination were prospectively recruited. All the patients underwent complete ophthalmologic evaluation, structural OCT scans and fundus autofluorescence imaging. The planned follow-up was of 3-years. Main outcome measures were ORT prevalence, mechanism of ORT formation, mean time needed for complete ORT formation, best-corrected visual acuity (BCVA), definitely decreased autofluorescence (DDAF) area, questionably decreased autofluorescence (QDAF) area, retinal layer thickness, foveal sparing, number of intravitreal injections. We also assessed the possible role of external limiting membrane (ELM) and Müller cells in ORT pathogenesis. Seventy eyes (70 patients) were included; 43 showed dry AMD evolving to geographic atrophy, while 27 displayed the features of wet AMD. Baseline BCVA was 0.5 ± 0.5 LogMAR, decreasing to 0.9 ± 0.5 LogMAR at the 3-year follow-up (p < 0.01). We detected completely formed ORT in 26/70 eyes (37%), subdivided as follows: 20 eyes (77%) wet AMD and 6 eyes (23%) dry AMD (p < 0.01). ORT took 18 ± 8 months (range 3–35 months) to develop fully. We described the steps leading to ORT development, characterized by progressive involvement of, and damage to the photoreceptors, the ELM and the RPE. Eyes displaying ORT were associated with a smaller QDAF area, less retinal layers damage and lower rate of foveal sparing than eyes free of ORT (p < 0.01). We also described pigment accumulations simulating ORT, which were detected in 16/70 eyes (23%), associated with a greater loss of foveal sparing, increased DDAF area and smaller QDAF area at the 3-year follow-up (p < 0.01). In conclusion, this study provided a description of the steps leading to ORT development in AMD. ELM and Müller cells showed a role in ORT pathogenesis. Furthermore, we described a subtype of pigment hypertrophy mimicking ORT, evaluating its clinical utility.

scholarly journals A Risk Score for the Prediction of Advanced Age-Related Macular Degeneration

Ophthalmology ◽  
2014 ◽  
Vol 121 (7) ◽  
pp. 1421-1427 ◽  
Author(s):  
Chung-Jung Chiu ◽  
Paul Mitchell ◽  
Ronald Klein ◽  
Barbara E. Klein ◽  
Min-Lee Chang ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Risk Score ◽  
Age Related Macular Degeneration ◽  
Advanced Age ◽  
Age Related

RAD51 gene is associated with advanced age-related macular degeneration in Chinese population

2013 ◽  
Vol 46 (16-17) ◽  
pp. 1689-1693 ◽  
Author(s):  
Jie Zhou ◽  
Dan Wang ◽  
Junjun Zhang ◽  
Meixia Zhang ◽  
Fang Lu ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Chinese Population ◽  
Age Related Macular Degeneration ◽  
Advanced Age ◽  
Rad51 Gene ◽  
Age Related

Diminished Foveal Sensitivity May Predict the Development of Advanced Age-related Macular Degeneration

Ophthalmology ◽  
1989 ◽  
Vol 96 (3) ◽  
pp. 375-381 ◽  
Author(s):  
Janet S. Sunness ◽  
Robert W. Massof ◽  
Mary A. Johnson ◽  
Neil M. Bressler ◽  
Susan B. Bressler ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Advanced Age ◽  
Age Related ◽  
Foveal Sensitivity
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