Prostanoid EP4Receptor Stimulation Produces Ocular Hypotension by a Mechanism That Does Not Appear to Involve Uveoscleral Outflow

David F. Woodward; Siv F. E. Nilsson; Carol B. Toris; Alexander B. Kharlamb; Amelia L. Nieves; Achim H.-P. Krauss

doi:10.1167/iovs.08-3031

Prostanoid EP4Receptor Stimulation Produces Ocular Hypotension by a Mechanism That Does Not Appear to Involve Uveoscleral Outflow

Investigative Opthalmology & Visual Science ◽

10.1167/iovs.08-3031 ◽

2009 ◽

Vol 50 (7) ◽

pp. 3320 ◽

Cited By ~ 23

Author(s):

David F. Woodward ◽

Siv F. E. Nilsson ◽

Carol B. Toris ◽

Alexander B. Kharlamb ◽

Amelia L. Nieves ◽

...

Keyword(s):

Uveoscleral Outflow ◽

Ocular Hypotension

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Increased uveoscleral outflow as a possible mechanism of ocular hypotension caused by prostaglandin F2α-1-isopropylester in the cynomolgus monkey

Experimental Eye Research ◽

10.1016/0014-4835(89)90011-0 ◽

1989 ◽

Vol 48 (5) ◽

pp. 707-716 ◽

Cited By ~ 174

Author(s):

Siv F.E. Nilsson ◽

Maria Samuelsson ◽

Anders Bill ◽

Johan Stjernschantz

Keyword(s):

Cynomolgus Monkey ◽

Prostaglandin F2α ◽

Uveoscleral Outflow ◽

Ocular Hypotension

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Surgical resection of the sclera is a non-penetrating operation for the treatment of patients with primary open-angle and secondary glaucoma

GlaucomaNews ◽

10.25276/2227-8281-1-62-65 ◽

2020 ◽

pp. 62-65

Author(s):

А.Y. Kazantseva ◽

◽

O.A. Rumyantseva ◽

Keyword(s):

Surgical Resection ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Secondary Glaucoma ◽

Ophthalmological Examination ◽

Open Angle ◽

Visual Functions ◽

Dynamic Observation ◽

Uveoscleral Outflow ◽

Outflow Pathway

Purpose. To evaluate the effectiveness of surgical resection of the sclera in patients with primary open-angle and secondary glaucoma. Materials and methods. The study included 84 patients with POAG and SG stages III-IV and decompensated IOP level (not higher than 32 mm Hg). In order to normalize the increased ophthalmotonus, a non - penetrating operation was performed-surgical resection of the sclera (SRS). The patients underwent complex ophthalmological examination and dynamic observation. Result. In the studied groups of patients after surgical treatment there was a decrease in elevated IOP levels by 33.42%, an improvement in the coefficient of ease of outflow and a weakening of the hypotensive regime. Stabilization of visual functions was observed in all patients. Summary. The proposed new SRS technique provides a smooth decrease in IOP, preservation of visual functions and is not accompanied by intra-and postoperative complications. Key words: primary open-angle glaucoma, surgical resection of sclera, secondary glaucoma, uveoscleral outflow pathway (USPO), intraocular pressure, EO coefficient .

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