scholarly journals Thickness of Receptor and Post-receptor Retinal Layers in Patients with Retinitis Pigmentosa Measured with Frequency-Domain Optical Coherence Tomography

2009 ◽  
Vol 50 (5) ◽  
pp. 2328 ◽  
Author(s):  
Donald C. Hood ◽  
Christine E. Lin ◽  
Margot A. Lazow ◽  
Kirsten G. Locke ◽  
Xian Zhang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Retinitis Pigmentosa ◽  
Frequency Domain ◽  
Optical Coherence ◽  
Retinal Layers

scholarly journals Optical coherence tomography angiography findings in patients undergoing transcorneal electrical stimulation for treating retinitis pigmentosa

2020 ◽  
Author(s):  
Olga Zabek ◽  
Hanna Camenzind Zuche ◽  
Ursula Müller ◽  
Hendrik P. N. Scholl ◽  
Annekatrin Rickmann ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Electrical Stimulation ◽  
Retinitis Pigmentosa ◽  
Optical Coherence Tomography Angiography ◽  
Statistical Significance ◽  
Vascular Density ◽  
Optical Coherence ◽  
Transcorneal Electrical Stimulation ◽  
Retinal Layers ◽  
Perfusion Density

Abstract Purpose Transcorneal electrical stimulation (TES) is a novel treatment approach for patients with retinitis pigmentosa (RP). The aim of our study was to observe changes in optical coherence tomography angiography (OCTA) that would be attributed to TES treatment. Methods A total of 73 eyes were included: 43 eyes of 22 subjects (11 ♀, 11 ♂) suffering from RP were examined at baseline (BL), after first stimulation (TS), 1 week (1W), and 6 months (6M) after treatment initiation and were compared with 30 control eyes of 15 subjects (8 ♀, 7 ♂). TES was performed simultaneously on both eyes for 30 min weekly. OCTA scans of 9 × 15 mm were recorded with a PLEX Elite 9000 swept-source OCTA device (Carl Zeiss Meditec AG, Jena). Vascular density metrics such as perfusion density (PD) and vessel density (VD) were calculated automatically for the macular area by using standardised extended early treatment diabetic retinopathy study (ETDRS) grids centred around the fovea. In addition, the capillary perfusion density (CPD) and the capillary flux index (CFI) of the peripapillary nerve fibre layer microvasculature in all four quadrants of an annulus centred at the optic disc were measured. All parameters were determined over all retinal layers and separately for the superficial (SCP) and deep capillary plexus (DCP). ANOVA-based linear mixed-effects models were calculated with SPSS®. Results Throughout the course of TES treatment, the macular VD and PD of all retinal layers in all subsections showed a slight decrement without reaching statistical significance, also when analysed separately in the SCP and DCP (p > 0.08). In analogy, the average CPD and CFI also presented with a slight decrement (p > 0.20). However, when compared with controls, most OCTA parameters showed a significant decrement (p < 0.05). When analysed systematically in all subsections of the extended ETDRS grid, the temporal macular subsections within the outer ring (radius 1.5–3 mm) and also of the peripheral C1, C2, and C3 rings (radius 3–7.5 mm) showed lower VD and PD values when compared with the other subsections (p < 0.05). Conclusion Vascular density metrics in the macular region and the peripapillary microvasculature appear to remain unaffected by continuous TES treatment within a period of 6 months.

Ultra-wide field imaging of pigmented para-venous retino-choroidal atrophy

2018 ◽  
Vol 29 (4) ◽  
pp. 444-452 ◽  
Author(s):  
Vinod Kumar ◽  
Devesh Kumawat ◽  
Ruchir Tewari ◽  
Pradeep Venkatesh
Keyword(s):  
Optical Coherence Tomography ◽  
Retinitis Pigmentosa ◽  
Retrospective Review ◽  
Wide Field ◽  
Imaging Features ◽  
Optical Coherence ◽  
Swept Source ◽  
Retinal Layers ◽  
Field Imaging ◽  
Wide Field Imaging

Objective: To describe the ultra-wide field imaging features of pigmented para-venous retino-choroidal atrophy. Design: Retrospective review at a tertiary care centre. Participants: Eight eyes of five patients with pigmented para-venous retino-choroidal atrophy who presented to our retina clinic over last 2 years. Methods: Retrospective review of ultra-wide field pseudo-colour and short wave autofluorescence imaging was performed. In vivo histology of the macula and areas of retino-choroidal atrophy was studied with swept source optical coherence tomography (SS-OCT). Results: The median age was 40 years (range: 22–67 years). Best corrected visual acuity ranged from perception of light to 20/20. The para-venous retino-choroidal atrophy and pigment clumping not only involved the major arcade vessels but also extended into the peripapillary area and retinal periphery. The affected areas demonstrated hypoautofluorescence with sharp hyperautofluorescent borders. Macular atrophy, epiretinal membrane and optic disc pallor were noted in two eyes each. In all cases, the affected pigmentary area had disorganization of inner retinal layers, disruption of outer retinal layers and retinal pigment epithelium and markedly thinned out choroid on swept source optical coherence tomography. Concurrent involvement with retinitis pigmentosa in the fellow eye was noted in two patients. Conclusion: Ultra-wide field imaging of pigmented para-venous retino-choroidal atrophy sheds light onto the widespread retino-choroidal abnormalities. Concurrent disc and macular involvement may jeopardize the visual function. Pigmented para-venous retino-choroidal atrophy may be considered as a self-limited form of retinitis pigmentosa.

scholarly journals Rates of Decline in Regions of the Visual Field Defined by Frequency-Domain Optical Coherence Tomography in Patients with RPGR-Mediated X-Linked Retinitis Pigmentosa

Ophthalmology ◽  
2015 ◽  
Vol 122 (4) ◽  
pp. 833-839 ◽  
Author(s):  
David G. Birch ◽  
Kirsten G. Locke ◽  
Joost Felius ◽  
Martin Klein ◽  
Dianna K.H. Wheaton ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Field ◽  
Retinitis Pigmentosa ◽  
Frequency Domain ◽  
Optical Coherence

scholarly journals Optical coherence tomography angiography (OCT-A) in retinitis pigmentosa and macular dystrophy patients: a retrospective study

2022 ◽  
Author(s):  
Sebastian Deutsch ◽  
Albrecht Lommatzsch ◽  
Silke Weinitz ◽  
Ghazaleh Farmand ◽  
Ulrich Kellner
Keyword(s):  
Optical Coherence Tomography ◽  
Retrospective Study ◽  
Retinitis Pigmentosa ◽  
Surface Area ◽  
Optical Coherence Tomography Angiography ◽  
Macular Dystrophy ◽  
Optical Coherence ◽  
Healthy Individuals ◽  
Vascular Abnormalities ◽  
Retinal Layers

Abstract Purpose To evaluate macular vascular abnormalities in patients with macular dystrophies (MD) and retinitis pigmentosa (RP) through application of optical coherence tomography angiography (OCT-A). Methods In this retrospective study, patients with MD and RP were examined by OCT-A and compared to healthy individuals. OCT-A images were analyzed regarding the diameter and surface area of the foveal avascular zone (FAZ) as well as flow (FL) in different retinal layers (superficial vascular complex (SVC), intermediate capillary complex (ICP), deep capillary complex (DCP), choriocapillaris (CC), and choroid (CD)). Results Twenty-one patients with MD, 21 patients with RP without macular edema (RPnE), 8 patients with RP with edema (RPwE), and 41 healthy individuals were enrolled. The group of MD and RPnE patients showed none or only minor changes in FAZ. In RPwE patients, the FAZ was significantly smaller in vertical and horizontal measurements and surface area in SVC, whereas it was markedly enlarged in ICP. FL was significantly reduced compared to healthy individuals by an average of 13.2% in CD, 14.2% in CC, and 8.4% in DCP in all patient groups. In ICP, the reduction was 9.2% for RPnE and 12.7% for RPwE patients. The SVC showed reduced FL in the MD (8.1%) and RPnE (10.3%) group. Conclusions OCT-A is a valuable tool to examine retinal vascular abnormalities in patients with MD and RP. OCT-A revealed a reduced flow in various retinal layers in MD, RPnE, and RPwE. Alterations of the FAZ were less distinct in these groups which add to the variation reported previously.

A novel 3D segmentation approach for extracting retinal layers from optical coherence tomography images

2021 ◽  
Author(s):  
Ahmed A. Sleman ◽  
Ahmed Soliman ◽  
Mohamed Elsharkawy ◽  
Guruprasad Giridharan ◽  
Mohammed Ghazal ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
3D Segmentation ◽  
Retinal Layers ◽  
Segmentation Approach

Retinal layers in prolactinoma patients: a spectral-domain optical coherence tomography study

2021 ◽  
Author(s):  
Berna Evranos Ogmen ◽  
Nagihan Ugurlu ◽  
Sevgül Faki ◽  
Sefika Burcak Polat ◽  
Reyhan Ersoy ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Retinal Layers

scholarly journals Full-field time-encoded frequency-domain optical coherence tomography

2006 ◽  
Vol 14 (17) ◽  
pp. 7661 ◽  
Author(s):  
Boris Považay ◽  
Angelika Unterhuber ◽  
Boris Hermann ◽  
Harald Sattmann ◽  
Holger Arthaber ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Frequency Domain ◽  
Optical Coherence ◽  
Full Field
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