scholarly journals Elastin-Mediated Choroidal Endothelial Cell Migration: Possible Role in Age-Related Macular Degeneration

2008 ◽  
Vol 49 (12) ◽  
pp. 5574 ◽  
Author(s):  
Jessica M. Skeie ◽  
Robert F. Mullins
Keyword(s):  
Cell Migration ◽  
Endothelial Cell ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Endothelial Cell Migration ◽  
Age Related ◽  
Choroidal Endothelial Cell

scholarly journals Regulation of Rac1 Activation in Choroidal Endothelial Cells: Insights into Mechanisms in Age-Related Macular Degeneration

Cells ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 2414
Author(s):  
Aniket Ramshekar ◽  
Haibo Wang ◽  
M. Elizabeth Hartnett
Keyword(s):  
Endothelial Cells ◽  
Cell Migration ◽  
Endothelial Cell ◽  
Macular Degeneration ◽  
Neural Retina ◽  
Age Related Macular Degeneration ◽  
Endothelial Cell Migration ◽  
Iq Motif ◽  
Age Related ◽  
Choroidal Endothelial Cell

Age-related macular degeneration (AMD) is one of the leading causes of blindness worldwide. Vision loss from the neovascular form is associated with the invasion of choroidal endothelial cells into the neural retina to form vision-threatening macular neovascularization (MNV). Anti-angiogenic agents are the current standard of care but are effective in only ~50% of AMD cases. The molecular mechanisms involved in invasive MNV point to the importance of regulating signaling pathways that lead to pathologic biologic outcomes. In studies testing the effects of AMD-related stresses, activation of the Rho GTPase, Rac1, was found to be important for the choroidal endothelial cell invasion into the neural retina. However, current approaches to prevent Rac1 activation are inefficient and less effective. We summarize active Rac1-mediated mechanisms that regulate choroidal endothelial cell migration. Specifically, we discuss our work regarding the role of a multidomain protein, IQ motif containing GTPase activating protein 1 (IQGAP1), in sustaining pathologic Rac1 activation and a mechanism by which active Rap1, a Ras-like GTPase, may prevent active Rac1-mediated choroidal endothelial cell migration.

scholarly journals Upregulation of CCR3 by Age-Related Stresses Promotes Choroidal Endothelial Cell Migration via VEGF-Dependent and -Independent Signaling

2011 ◽  
Vol 52 (11) ◽  
pp. 8271 ◽  
Author(s):  
Haibo Wang ◽  
Erika S. Wittchen ◽  
Yanchao Jiang ◽  
Balamurali Ambati ◽  
Hans E. Grossniklaus ◽  
...  
Keyword(s):  
Cell Migration ◽  
Endothelial Cell ◽  
Endothelial Cell Migration ◽  
Age Related ◽  
Choroidal Endothelial Cell

Serum anti-endothelial cell antibodies in patients with age-related macular degeneration treated with intravitreal bevacizumab

2016 ◽  
Vol 94 (7) ◽  
pp. e617-e623 ◽  
Author(s):  
Agnieszka Kubicka-Trząska ◽  
Joanna Wilańska ◽  
Bożena Romanowska-Dixon ◽  
Marek Sanak
Keyword(s):  
Endothelial Cell ◽  
Macular Degeneration ◽  
Intravitreal Bevacizumab ◽  
Age Related Macular Degeneration ◽  
Age Related
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