A Novel Antioxidant Function for the Tumor-Suppressor Gene p53 in the Retinal Ganglion Cell

2008 ◽  
Vol 49 (10) ◽  
pp. 4237-4244 ◽  
Author(s):  
J. C. O'Connor ◽  
D. M. Wallace ◽  
C. J. O'Brien ◽  
T. G. Cotter
Keyword(s):  
Tumor Suppressor ◽  
Ganglion Cell ◽  
Tumor Suppressor Gene ◽  
Retinal Ganglion Cell ◽  
Suppressor Gene ◽  
Retinal Ganglion ◽  
Antioxidant Function ◽  
Tumor Suppressor Gene P53

Mutational analysis of a dominant oncogene (c-Ki-ras-2) and a tumor suppressor gene (p53) in hamster lung tumorigenesis

1992 ◽  
Vol 6 (3) ◽  
pp. 199-202 ◽  
Author(s):  
Victor I. C. Oreffo ◽  
Hsiu-Wei Lin ◽  
Paul H. Gumerlock ◽  
Susan A. Kraegel ◽  
Hanspeter Witschi
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Mutational Analysis ◽  
Suppressor Gene ◽  
Lung Tumorigenesis ◽  
Tumor Suppressor Gene P53

scholarly journals Correlation of primary tumor size and axillary nodal status with tumor suppressor gene p53 in breast carcinoma

2002 ◽  
Vol 59 (1) ◽  
pp. 29-32 ◽  
Author(s):  
Brano Topic ◽  
Nebojsa Stankovic ◽  
Dragutin Savjak ◽  
Slavko Grbic
Keyword(s):  
Prognostic Factors ◽  
Breast Carcinoma ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Tumor Size ◽  
Primary Tumor ◽  
Suppressor Gene ◽  
Nodal Status ◽  
Primary Tumor Size ◽  
Tumor Suppressor Gene P53

Correlation of standard path morphological prognostic parameters, primary tumor size and axillary nodal status with new prognostic factor in breast carcinoma: tumor suppressor gene p53 was analyzed. The studied sample included 65 women who underwent surgery for breast carcinoma at the Surgical Clinic of Clinical Center Banja Luka, from January 1st 1997 till January 1st 1999. Statistical data analysis was performed and correlation of prognostic factors was determined. The majority of authors in this field agree that the primary tumor size and axillary nodal status are the two most important prognostic factors. These factors are the best predictors of prognosis and survival of women who had the tumor and were operated on. Tumor markers were immunohistochemically determined in the last ten years and, according to the majority of authors, are still considered the additional or relative prognostic factors in breast carcinoma. Their prognostic value and significance increase almost daily. Most frequently determined tumor markers are bcl-2, pS2, Ki-67 and p53. There was a positive, directly proportional relationship between primary tumor size and tumor suppressor gene p53, but there was no positive correlation between the axillary nodal status and tumor suppressor gene p53. Significance of determination of new tumor markers as the prognostic factors was emphasized. These markers represent a powerful tool in the early detection and prevention of breast carcinoma.

A synergistic polyphosphoester-based co-delivery system of the anticancer drug doxorubicin and the tumor suppressor gene p53 for lung cancer therapy

2018 ◽  
Vol 6 (20) ◽  
pp. 3262-3273 ◽  
Author(s):  
Jie Liu ◽  
Jinlin He ◽  
Mingzu Zhang ◽  
Guoqiang Xu ◽  
Peihong Ni
Keyword(s):  
Lung Cancer ◽  
Cancer Therapy ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Anticancer Drug ◽  
Delivery System ◽  
Suppressor Gene ◽  
Polymeric Prodrug ◽  
Lung Cancer Therapy ◽  
Tumor Suppressor Gene P53

Hybrid micelles composed of polymeric prodrug and gene carrier were constructed by polyphosphoester-based co-delivery system for lung cancer therapy.

Expression and Mutation of the Tumor Suppressor Gene p53 in AIDS-Associated Kaposi's Sarcoma

1997 ◽  
Vol 19 (4) ◽  
pp. 373-378 ◽  
Author(s):  
Jian J. Li ◽  
Yao-Q Huang ◽  
Clay J. Cockerell ◽  
Wei G. Zhang ◽  
Alexander Nicolaides ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Kaposi's Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Suppressor Gene ◽  
Tumor Suppressor Gene P53

Alteration of the Tumor Suppressor Gene p53 in a High Fraction of Hormone Refractory Prostate Cancer

1995 ◽  
pp. 414-421 ◽  
Author(s):  
Howard B. Heidenberg ◽  
Isabell A. Sesterhenn ◽  
Jaya P. Gaddipati ◽  
Christopher M. Weghorst ◽  
Gregory S. Buzard ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Hormone Refractory Prostate Cancer ◽  
High Fraction ◽  
Hormone Refractory ◽  
Tumor Suppressor Gene P53

scholarly journals Analysis of Tumor Suppressor Gene p53 in Chicken Lymphoblastoid Tumor Cell Lines and field Tumors.

1998 ◽  
Vol 60 (8) ◽  
pp. 923-929 ◽  
Author(s):  
Michihiro TAKAGI ◽  
Kazuhiko OHASHI ◽  
Toshifumi MORIMURA ◽  
Chihiro SUGIMOTO ◽  
Misao ONUMA
Keyword(s):  
Tumor Suppressor ◽  
Tumor Cell ◽  
Tumor Suppressor Gene ◽  
Cell Lines ◽  
Suppressor Gene ◽  
Tumor Cell Lines ◽  
Tumor Suppressor Gene P53

Analysis of the equine tumor suppressor gene p53 in the normal horse and in eight cutaneous squamous cell carcinomas

1996 ◽  
Vol 107 (1) ◽  
pp. 125-130 ◽  
Author(s):  
Karen A. Pazzi ◽  
Susan A. Kraegel ◽  
Stephen M. Griffey ◽  
Alain P. Theon ◽  
Bruce R. Madewell
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Squamous Cell ◽  
Suppressor Gene ◽  
Squamous Cell Carcinomas ◽  
Tumor Suppressor Gene P53
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