scholarly journals Remodeling of the Connective Tissue Microarchitecture of the Lamina Cribrosa in Early Experimental Glaucoma

2009 ◽  
Vol 50 (2) ◽  
pp. 681 ◽  
Author(s):  
Michael D. Roberts ◽  
Vicente Grau ◽  
Jonathan Grimm ◽  
Juan Reynaud ◽  
Anthony J. Bellezza ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Lamina Cribrosa ◽  
Experimental Glaucoma

Microstructure Motivated Growth and Remodeling of the Lamina Cribrosa in Early Glaucoma

2011 ◽  
Author(s):  
Rafael Grytz ◽  
Ian A. Sigal ◽  
Jeffrey W. Ruberti ◽  
J. Crawford Downs
Keyword(s):  
Connective Tissue ◽  
Structural Changes ◽  
Lamina Cribrosa ◽  
Posterior Pole ◽  
Retinal Ganglion ◽  
Experimental Glaucoma ◽  
Relevant Risk Factor ◽  
Orbital Space ◽  
Iop Elevation ◽  
Pass Through

Glaucoma is a leading cause of blindness in the world and is due to the loss of retinal ganglion cell axons. These axons deteriorate in a region in the posterior pole of the eye known as the optic nerve head (ONH). The axons pass through the lamina cribrosa (LC) as they exit the eye at the ONH. The LC is characterized by a porous, connective tissue structure composed of laminar beams. The function of the LC is unclear, but is believed to include providing mechanical support to the axons as they transition from inside the pressurized globe to the lower pressure orbital space. Early experimental glaucoma studies have shown that the LC remodels into a thicker, more posterior structure which incorporates more connective tissue after chronic IOP elevation [1,2]. The process by which this occurs is unknown. These structural changes are assumed to play an important role in the pathophysiology of the ocular disease glaucoma, where elevated IOP is known to be the most relevant risk factor.

scholarly journals Posterior (Outward) Migration of the Lamina Cribrosa and Early Cupping in Monkey Experimental Glaucoma

2011 ◽  
Vol 52 (10) ◽  
pp. 7109 ◽  
Author(s):  
Hongli Yang ◽  
Galen Williams ◽  
J. Crawford Downs ◽  
Ian A. Sigal ◽  
Michael D. Roberts ◽  
...  
Keyword(s):  
Lamina Cribrosa ◽  
Experimental Glaucoma ◽  
Outward Migration

scholarly journals In Vivo Changes in Lamina Cribrosa Microarchitecture and Optic Nerve Head Structure in Early Experimental Glaucoma

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0134223 ◽  
Author(s):  
Kevin M. Ivers ◽  
Nripun Sredar ◽  
Nimesh B. Patel ◽  
Lakshmi Rajagopalan ◽  
Hope M. Queener ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Lamina Cribrosa ◽  
Experimental Glaucoma

Large Scale Voxel-Based Finite Element Modeling of Normal and Early Glaucomatous Monkey Lamina Cribrosa

2008 ◽  
Author(s):  
Sanjay Kodiyalam ◽  
Michael D. Roberts ◽  
Ian A. Sigal ◽  
Richard T. Hart ◽  
Claude F. Burgoyne ◽  
...  
Keyword(s):  
Finite Element ◽  
Intraocular Pressure ◽  
Connective Tissue ◽  
Large Scale ◽  
Lamina Cribrosa ◽  
Posterior Pole ◽  
Stress And Strain ◽  
Structural Support ◽  
Elevated Intraocular Pressure ◽  
Related Stress

Glaucoma is a leading cause of blindness worldwide. Some of the chief clinical hallmarks of glaucoma are the permanent posterior cupping of the optic nerve head, in the posterior pole of the eye, and the accompanying damage to the lamina cribrosa — the fenestrated structure of connective tissue spanning the scleral canal that provides structural support to the axon bundles passing through it. While elevated intraocular pressure (IOP) is associated with this disease, its role remains unclear. It has been hypothesized that IOP-related stress and strain within the laminar connective tissue (LCT) underlie the onset and progression of glaucoma [1] and that they may be used to predict the location of axonal insult and the pattern of damage within the LCT.

scholarly journals The Connective Tissue Components of Optic Nerve Head Cupping in Monkey Experimental Glaucoma Part 1: Global Change

2015 ◽  
Vol 56 (13) ◽  
pp. 7661 ◽  
Author(s):  
Hongli Yang ◽  
Ruojin Ren ◽  
Howard Lockwood ◽  
Galen Williams ◽  
Vincent Libertiaux ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Global Change ◽  
Connective Tissue ◽  
Optic Nerve Head ◽  
Experimental Glaucoma

Biomechanics of the Posterior Pole During the Remodeling Progression From Normal to Early Experimental Glaucoma

2009 ◽  
Author(s):  
Ian A. Sigal ◽  
Hongli Yang ◽  
Michael D. Roberts ◽  
Claude F. Burgoyne ◽  
J. Crawford Downs
Keyword(s):  
Visual Information ◽  
Lamina Cribrosa ◽  
Posterior Pole ◽  
Glaucomatous Optic Neuropathy ◽  
Retinal Ganglion ◽  
Experimental Glaucoma ◽  
Pass Through ◽  
Mechanical Insult ◽  
The Brain ◽  
Connective Tissue Structure

Glaucoma is one of the leading causes of blindness worldwide. The loss of vision associated with glaucoma is due to damage to the retinal ganglion cell axons, which transmit visual information to the brain. Damage to these axons is believed to occur as the axons pass through the lamina cribrosa (LC), a connective tissue structure in the optic nerve head at the back of the eye. Elevated intraocular pressure (IOP) has been identified as the main risk factor for the development of the neuropathy, but the mechanism(s) by which a mechanical insult (elevated IOP) is translated into a biological effect (glaucomatous optic neuropathy) is not well understood.

scholarly journals Lamina Cribrosa Microarchitecture in Monkey Early Experimental Glaucoma: Global Change

2016 ◽  
Vol 57 (7) ◽  
pp. 3451 ◽  
Author(s):  
Juan Reynaud ◽  
Howard Lockwood ◽  
Stuart K. Gardiner ◽  
Galen Williams ◽  
Hongli Yang ◽  
...  
Keyword(s):  
Global Change ◽  
Lamina Cribrosa ◽  
Experimental Glaucoma
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