Development and Characterization of an Adult Retinal Explant Organotypic Tissue Culture System as an In Vitro Intraocular Stem Cell Transplantation Model

2008 ◽  
Vol 49 (8) ◽  
pp. 3503 ◽  
Author(s):  
Thomas V. Johnson ◽  
Keith R. Martin
Keyword(s):  
Tissue Culture ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Culture System ◽  
Tissue Culture System ◽  
Organotypic Tissue ◽  
Transplantation Model

scholarly journals The Porcine Aortic Tissue Culture System in vitro for Stem Cell Research

2011 ◽  
Vol 4 (2) ◽  
pp. 116-122
Author(s):  
Dong-Eun Kim ◽  
Keun-Hee Oh ◽  
Ji-Hye Yang ◽  
Sun-Keun Kwon ◽  
Tae-Jun Cho ◽  
...  
Keyword(s):  
Tissue Culture ◽  
Stem Cell ◽  
Stem Cell Research ◽  
Culture System ◽  
Aortic Tissue ◽  
Tissue Culture System

scholarly journals Dose-Independent Therapeutic Benefit of Bone Marrow Stem Cell Transplantation after MI in Mice

Biomedicines ◽  
2020 ◽  
Vol 8 (6) ◽  
pp. 157
Author(s):  
Nicole Zarniko ◽  
Anna Skorska ◽  
Gustav Steinhoff ◽  
Robert David ◽  
Ralf Gaebel
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Ex Vivo ◽  
Therapeutic Benefit ◽  
Dependent Manner ◽  
Mesenchymal Progenitors

Several cell populations derived from bone marrow (BM) have been shown to possess cardiac regenerative potential. Among these are freshly isolated CD133+ hematopoietic as well as culture-expanded mesenchymal stem cells. Alternatively, by purifying CD271+ cells from BM, mesenchymal progenitors can be enriched without an ex vivo cultivation. With regard to the limited available number of freshly isolated BM-derived stem cells, the effect of the dosage on the therapeutic efficiency is of particular interest. Therefore, in the present pre-clinical study, we investigated human BM-derived CD133+ and CD271+ stem cells for their cardiac regenerative potential three weeks post-myocardial infarction (MI) in a dose-dependent manner. The improvement of the hemodynamic function as well as cardiac remodeling showed no therapeutic difference after the transplantation of both 100,000 and 500,000 stem cells. Therefore, beneficial stem cell transplantation post-MI is widely independent of the cell dose and detrimental stem cell amplification in vitro can likely be avoided.

Characterization of the Inflammatory Response in a Photothrombotic Stroke Model by MRI: Implications for Stem Cell Transplantation

2010 ◽  
Vol 13 (4) ◽  
pp. 663-671 ◽  
Author(s):  
Caroline Vandeputte ◽  
Debby Thomas ◽  
Tom Dresselaers ◽  
Annelies Crabbe ◽  
Catherine Verfaillie ◽  
...  
Keyword(s):  
Stem Cell ◽  
Inflammatory Response ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Stroke Model ◽  
Photothrombotic Stroke
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