Benefits and Side Effects of Different Vegetable Oil Vectors on Apoptosis, Oxidative Stress, and P2X7 Cell Death Receptor Activation

2007 ◽  
Vol 48 (11) ◽  
pp. 5000 ◽  
Author(s):  
Toihiri Said ◽  
Me´lody Dutot ◽  
Raymond Christon ◽  
Jean-Louis Beaudeux ◽  
Chantal Martin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Side Effects ◽  
Vegetable Oil ◽  
Death Receptor ◽  
Receptor Activation ◽  
Cell Death Receptor

Fluoroquinolone Eye Drop–Induced Cytotoxicity: Role of Preservative in P2X7 Cell Death Receptor Activation and Apoptosis

2006 ◽  
Vol 47 (7) ◽  
pp. 2812 ◽  
Author(s):  
Me´lody Dutot ◽  
Franc¸ois Pouzaud ◽  
Isabelle Larosche ◽  
Franc¸oise Brignole-Baudouin ◽  
Jean-Michel Warnet ◽  
...  
Keyword(s):  
Cell Death ◽  
Death Receptor ◽  
Receptor Activation ◽  
Cell Death Receptor

Stevens-Johnson syndrome manifesting late in the course of pembrolizumab therapy

2018 ◽  
Vol 25 (6) ◽  
pp. 1520-1522 ◽  
Author(s):  
Andrew Hwang ◽  
Andrew Iskandar ◽  
Constantin A Dasanu
Keyword(s):  
Cell Death ◽  
Side Effects ◽  
Programmed Cell Death ◽  
Toxic Epidermal Necrolysis ◽  
Death Receptor ◽  
Favorable Outcome ◽  
Stevens Johnson Syndrome ◽  
Erythematous Rash ◽  
Johnson Syndrome ◽  
Cell Death Receptor

Pembrolizumab is a humanized antibody that targets programmed cell death receptor-1. This agent is approved for use in the treatment of several malignancies. While pruritus and papulo-erythematous rash are not uncommon with its use, severe reactions such as Stevens-Johnson syndrome/toxic epidermal necrolysis are very rare. We present herein a case of Stevens-Johnson syndrome occurring in a patient who had previously tolerated pembrolizumab without significant side effects for seven months. Prompt recognition of Stevens-Johnson syndrome/toxic epidermal necrolysis and discontinuation of the offending agent are paramount to ensure a favorable outcome.

IMMUNOLOGICAL DISORDERS OF THE REPRODUCTIVE SYSTEM THAT OCCUR WHEN EXPOSED TO BENZENE, IN EMPLOYEES OF OIL-PRODUCING ENTERPRISES

2021 ◽  
Author(s):  
I.V. Leshkova ◽  
◽  
O.V. Dolgih ◽  
O.YU. Ustinova
Keyword(s):  
Cell Death ◽  
Reproductive Health ◽  
Reproductive System ◽  
Death Receptor ◽  
Annexin V ◽  
Reference Level ◽  
Immunological Disorders ◽  
Cellular Expression ◽  
Cell Death Receptor

Abstract. Introduction. The protection of the reproductive health of the working-age population is the most important direction of State policy. In 5-15% of cases, the causes of reproductive dysfunction are immunological disorders. Benzene belongs to the group of industrial reprotoxicants, however, its effect of benzene on the reproductive system has not been sufficiently studied. Objective: to study the immunological aspects of the effect of benzene on the reproductive system. Methods. We examined 50 men exposed to benzene with reproductive disorders (26-49 years old), as well as 4 workers with normal sexual function aged 53-60 years. Spontaneous and induced changes in the cellular expression of apoptosis markers were studied. For the study, the ANNEXIN V-FITC/7-AAD kit was used for the detection of cells that have undergone apoptosis. The experiment was conducted in vitro using a biological medium (ejaculate). A factor of the chemical nature was benzene. Results. According to the results of the comparative analysis, there were no significant deviations of pathogenetic tests of immunological markers in comparison with the reference level in the spontaneous expression samples, but there was an excess of expression of the CD95 + cell death receptor (p<0.05) in 30% of the samples examined, and a decrease in the number of Annexin V-FITC+7AAD negative cells (without reaching the significance level) in samples with a load of (15%). There was a difference in the expression levels of CD95+ and CD25+ CD-reception indicators by 20% and 10% in relation to the spontaneous level (p<0.05). Representatives of the chemical group of aromatic hydrocarbons realize reprotoxicity, using the mechanism of excessive induction of the membrane signaling of the cell death receptor, accelerate the natural program of cell death by approximately 20% compared to the state of reproductive cells that were not stimulated. Conclusion. At the present stage, one of the tasks of occupational medicine is to study the effect of chemicals on the processes of reproduction, to develop new approaches to assessing the risk of their impact on the reproductive health of workers.

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