Interleukin Gene Polymorphisms in Age-Related Macular Degeneration

2008 ◽  
Vol 49 (2) ◽  
pp. 693 ◽  
Author(s):  
Yi-Yu Tsai ◽  
Jane-Ming Lin ◽  
Lei Wan ◽  
Hui-Ju Lin ◽  
Yushin Tsai ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Gene Polymorphisms ◽  
Age Related Macular Degeneration ◽  
Age Related

scholarly journals Investigation of associations of ARMS2, CD14, and TLR4 gene polymorphisms with wet age-related macular degeneration in a Greek population

2017 ◽  
Vol Volume 11 ◽  
pp. 1347-1358 ◽  
Author(s):  
Antonia Sarli ◽  
Iosif Skalidakis ◽  
Aliki Velissari ◽  
Chryssanthi Koutsandrea ◽  
Maria Stefaniotou ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Gene Polymorphisms ◽  
Age Related Macular Degeneration ◽  
Greek Population ◽  
Age Related ◽  
Em Gene

Gene polymorphisms associated with an increased risk of exudative age-related macular degeneration in a Spanish population

2021 ◽  
pp. 112067212110026
Author(s):  
Pablo Gili ◽  
Leyre Lloreda Martín ◽  
José-Carlos Martín-Rodrigo ◽  
Naon Kim-Yeon ◽  
Laura Modamio-Gardeta ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Gene Polymorphisms ◽  
Age Related Macular Degeneration ◽  
Spanish Population ◽  
Healthy Controls ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Exudative Amd ◽  
Age Related ◽  
Increased Risk

Purpose: To identify the association between single-nucleotide polymorphisms (SNPs) in CFH, ARMS2, HTRA1, CFB, C2, and C3 genes and exudative age-related macular degeneration (AMD) in a Spanish population. Methods: In 187 exudative AMD patients and 196 healthy controls (61% women, mean age 75 years), 12 SNPs as risk factors for AMD in CFH (rs1410996, rs1061170, r380390), ARMS2 (rs10490924, rs10490923), HTRA1 (rs11200638), CFB (rs641153), C2 (rs547154, rs9332739), and C3 (rs147859257, rs2230199, rs1047286) genes were analyzed. Results: The G allele was the most frequent in CFH gene (rs1410996) with a 7-fold increased risk of AMD (OR 7.69, 95% CI 3.17–18.69), whereas carriers of C allele in CFH (rs1061170) showed a 3-fold increased risk for AMD (OR 3.22, 95% CI 1.93–5.40). In CFH (rs380390), the presence of G allele increased the risk for AMD by 2-fold (OR 2.52, 95% CI 1.47–4.30). In ARMS2 (rs10490924), the T-allele was associated with an almost 5-fold increased risk (OR 5.49, 95% CI 3.23–9.31). The A allele in HTRA1 (rs11200638) was more prevalent in AMD versus controls (OR 6.44, 95% CI 3.62–11.47). In C2 gene (rs9332739) the presence of C increased risk for AMD by 3-fold (OR 3.10, 95% CI 1.06–9.06). Conclusion: SNPs in CFH, ARMS2, HTRA1, and C2 genes were associated in our study with an increased risk for exudative AMD in Spanish patients.

Investigating the CFH Gene Polymorphisms as a Risk Factor for Age-related Macular Degeneration in an Iranian Population

2015 ◽  
Vol 37 (2) ◽  
pp. 144-149 ◽  
Author(s):  
Mojgan Babanejad ◽  
Hamidreza Moein ◽  
Mohammad R. Akbari ◽  
Azadeh Badiei ◽  
Mehdi Yaseri ◽  
...  
Keyword(s):  
Risk Factor ◽  
Macular Degeneration ◽  
Gene Polymorphisms ◽  
Iranian Population ◽  
Age Related Macular Degeneration ◽  
Age Related

Associations between Rs4244285 and Rs762551 gene polymorphisms and age-related macular degeneration

2017 ◽  
Vol 38 (4) ◽  
pp. 357-364 ◽  
Author(s):  
Neringa Stasiukonyte ◽  
Rasa Liutkeviciene ◽  
Alvita Vilkeviciute ◽  
Mantas Banevicius ◽  
Loresa Kriauciuniene
Keyword(s):  
Macular Degeneration ◽  
Gene Polymorphisms ◽  
Age Related Macular Degeneration ◽  
Age Related

Cytokine gene polymorphisms in patients with age-related macular degeneration

2016 ◽  
Vol 132 (2) ◽  
pp. 8 ◽  
Author(s):  
A. V. Shevchenko ◽  
V. F. Prokof’ev ◽  
V. I. Konenkov ◽  
V. V. Chernykh ◽  
A. V. Eremina ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Gene Polymorphisms ◽  
Age Related Macular Degeneration ◽  
Cytokine Gene ◽  
Age Related ◽  
Cytokine Gene Polymorphisms
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