Progression of Diabetic Macular Edema: Correlation with Blood–Retinal Barrier Permeability, Retinal Thickness, and Retinal Vessel Diameter

2007 ◽  
Vol 48 (9) ◽  
pp. 3983 ◽  
Author(s):  
Birgit Sander ◽  
Dorte Nellemann Thornit ◽  
Lotte Colmorn ◽  
Charlotte Strøm ◽  
Aniz Girach ◽  
...  
1998 ◽  
Vol 8 (3) ◽  
pp. 127-130 ◽  
Author(s):  
J. Cunha-Vaz

Retinal edema is defined as any increase of water in retinal tissue resulting in an increase in its volume. This increase may be initially intracellular or extracellular. In the first case, there is cytotoxic edema. In the second, vasogenic edema, directly associated with an alteration of the blood-retinal barrier (BRB). Retinal thickness can now be measured, using the retinal thickness analyser (RTA). Similarly, local breakdown of the BRB can now be mapped using the retinal leakage analyser (RLA). The application of these methods to diabetic macular edema has shown that both types of retinal retinopathy edema occur in the initial stages of diabetic retinal disease. These observations suggest a role for neuroprotective and vasoprotective agents in the management of diabetic retinal disease.


2005 ◽  
Vol 46 (10) ◽  
pp. 3855 ◽  
Author(s):  
Charlotte Strøm ◽  
Birgit Sander ◽  
Kristian Klemp ◽  
Lloyd Paul Aiello ◽  
Henrik Lund-Andersen ◽  
...  

2006 ◽  
Vol 47 (9) ◽  
pp. 4026 ◽  
Author(s):  
Asan Kochkorov ◽  
Konstantin Gugleta ◽  
Claudia Zawinka ◽  
Robert Katamay ◽  
Josef Flammer ◽  
...  

2012 ◽  
Vol 22 (5) ◽  
pp. 785-791 ◽  
Author(s):  
Sokratis T. Kotsidis ◽  
Simeon S. Lake ◽  
Alexandros D. Alexandridis ◽  
Nikolaos G. Ziakas ◽  
Panagiotis K. Ekonomidis

2015 ◽  
Vol 56 (13) ◽  
pp. 7915 ◽  
Author(s):  
Eunjoo Yoo ◽  
Chungkwon Yoo ◽  
Bo-ram Lee ◽  
Tae-Eun Lee ◽  
Yong Yeon Kim

Author(s):  
Medine Gündoğan ◽  
Esra Vural ◽  
Nurettin Bayram ◽  
Orhan Altunel ◽  
Fatih Gündoğan ◽  
...  

2021 ◽  
Vol 10 (13) ◽  
pp. 32
Author(s):  
Bhim B. Rai ◽  
Ted Maddess ◽  
Corinne F. Carle ◽  
Emilie M. F. Rohan ◽  
Josh P. van Kleef ◽  
...  

2021 ◽  
Vol 14 (3) ◽  
pp. 416-422
Author(s):  
Yong Cheng ◽  
◽  
Ming-Wei Zhao ◽  
Tong Qian ◽  
◽  
...  

AIM: To evaluate the two-year outcomes of patients treated for diabetic macular edema (DME) with intravitreal Conbercept (IVC). METHODS: The clinical data of 30 DME patients (36 eyes) were retrospectively reviewed. The patients were treated with IVC for 3mo. Additional IVC was given at subsequent monthly visits, if needed (3+PRN). The patients were followed up for 24mo. RESULTS: The best-corrected visual acuity (BCVA) at 24mo significantly increased (66.7±15.3 letters) in comparison with the baseline (54.4±15.4 letters, P<0.0001). The mean improvement in BCVA was 11.0±2.9 letters. At 24mo, 44.1% of the eyes surveyed gained ≥15 letters, 52.9% of the eyes gained ≥10 letters, and 70.6% of the eyes gained ≥5 letters. No vision loss was noted in 96.8% of the eyes, and 5.9% of the eyes lost ≥5 letters, but ≤10 letters. The central retinal thickness (CRT) at 24mo was significantly reduced (277.1±122.9 μm) in comparison with the baseline (510.9±186.1 μm, P<0.0001). At 24mo, 43.3% of the patients had a CRT ≤250 μm. The mean number of injections over 24mo was 10.6±2.0. No severe eye or systemic adverse events related to either the drug or injection were noted. CONCLUSION: IVC is safe and effective for the treatment of DME.


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