Identification of a Zebrafish Cone Photoreceptor–Specific Promoter and Genetic Rescue of Achromatopsia in thenofMutant

2007 ◽  
Vol 48 (2) ◽  
pp. 522 ◽  
Author(s):  
Breanda´n N. Kennedy ◽  
Yolanda Alvarez ◽  
Susan E. Brockerhoff ◽  
George W. Stearns ◽  
Beata Sapetto-Rebow ◽  
...  
Author(s):  
Richard Frankham ◽  
Jonathan D. Ballou ◽  
Katherine Ralls ◽  
Mark D. B. Eldridge ◽  
Michele R. Dudash ◽  
...  

Having identified small geographically and genetically isolated populations, we need to determine whether they are suffering genetic erosion, and if so, whether there are any other populations to which they could be crossed. We should next ask whether crossing is expected to be harmful or beneficial, and if beneficial, whether the benefits would be large enough to justify a genetic rescue attempt. Here, we address these questions based on the principles established in the preceding chapters.


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