scholarly journals Macular Pigment and Lutein Supplementation inABCA4-Associated Retinal Degenerations

2007 ◽  
Vol 48 (3) ◽  
pp. 1319 ◽  
Author(s):  
Tomas S. Aleman ◽  
Artur V. Cideciyan ◽  
Elizabeth A. M. Windsor ◽  
Sharon B. Schwartz ◽  
Malgorzata Swider ◽  
...  
Keyword(s):  
Macular Pigment ◽  
Retinal Degenerations

Study of relationship between choroidal thickness and indicators of state macular pigment in young patients with myopic refraction

2020 ◽  
pp. 14-15
Author(s):  
L.V. Bushnina ◽  
◽  
N.V. Pomytkina ◽  
Е.L. Sorokin ◽  
◽  
...  
Keyword(s):  
Choroidal Thickness ◽  
Young Patients ◽  
Macular Pigment

Актуальность. Среди инвалидизирующих осложнений миопии атрофическая макулопатия занимает одно из лидирующих мест. Выявление взаимосвязи между состоянием хориоидеи и макулярного пигмента поможет в разработке методов выявления группы риска миопических атрофических макулярных изменений. Цель. Выяснение наличия взаимосвязи между количественными показателями состояния макулярного пигмента и толщиной хориоидеи у молодых пациентов с миопической рефракцией. Материал и методы. Обследовано 36 пациентов (36 глаз) молодого возраста с миопией. Кроме стандартных методов обследования пациентам проводилось измерение размера переднезадней оси (ПЗО) глаза, толщины хориоидеи, показателей состояния макулярного пигмента. Результаты. Выявлена прямая корреляция между размерами ПЗО и площадью распределения макулярного пигмента (r=0,489, p<0,01), объемом оптической плотности макулярного пигмента (r=0,397, p<0,05); обратная корреляция между толщиной хориоидеи, площадью распределения макулярного пигмента и объемом оптической плотности макулярного пигмента (r=-0,421, p<0,05 и r=-0,415, p<0,05 соответственно). Не выявлено корреляции между показателем оптической плотности макулярного пигмента и толщиной хориоидеи, размерами ПЗО. Это не укладывается в традиционное понимание того, что атрофический процесс наружных слоев сетчатки связан с недостатком их кровоснабжения, а, следовательно, с истончением хориоидеи. Выводы. По мере возрастания размеров ПЗО и уменьшения толщины хориоидеи увеличивается площадь распределения макулярного пигмента и объем его оптической плотности, хотя закономерных изменений оптической плотности макулярного пигмента не выявлено. Дальнейшие исследования динамики изменений макулярных пигментов при осевой миопии могут помочь в разработке методов прогнозирования формирования миопических изменений макулярной зоны

The role of the macular pigment optical density measurement in the diagnosis of eye diseases

2016 ◽  
Vol 16 (4) ◽  
pp. 197-200
Author(s):  
E.N. Eskina ◽  
◽  
E.A. Egorov ◽  
A.V. Belogurova ◽  
А.А. Gvetadze ◽  
...  
Keyword(s):  
Optical Density ◽  
Density Measurement ◽  
Macular Pigment ◽  
Eye Diseases ◽  
Macular Pigment Optical Density ◽  
Optical Density Measurement

Retinal Degenerations: From Cell Signaling to Cell Therapy; Pre-Clinical and Clinical Issues

2007 ◽  
Vol 7 (2) ◽  
pp. 121-129 ◽  
Author(s):  
Therese Cronin ◽  
Thierry Leveillard ◽  
Jose-Alain Sahel
Keyword(s):  
Cell Therapy ◽  
Cell Signaling ◽  
Clinical Issues ◽  
Retinal Degenerations

Differential role of Jak‐STAT signaling in retinal degenerations

2006 ◽  
Vol 20 (13) ◽  
pp. 2411-2413 ◽  
Author(s):  
Marijana Samardzija ◽  
Andreas Wenzel ◽  
Svenja Aufenberg ◽  
Markus Thiersch ◽  
Charlotte Remé ◽  
...  
Keyword(s):  
Retinal Degenerations ◽  
Stat Signaling

scholarly journals Macular Pigment Optical Density and Photoreceptor Outer Segment Length as Predisease Biomarkers for Age-Related Macular Degeneration

2020 ◽  
Vol 9 (5) ◽  
pp. 1347 ◽  
Author(s):  
Norihiro Nagai ◽  
Sakiko Minami ◽  
Misa Suzuki ◽  
Hajime Shinoda ◽  
Toshihide Kurihara ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Optical Density ◽  
Outer Segment ◽  
Macular Pigment ◽  
Age Related Macular Degeneration ◽  
Segment Length ◽  
Macular Pigment Optical Density ◽  
Photoreceptor Outer Segment ◽  
Age Related ◽  
Fellow Eyes

To explore predisease biomarkers, which may help screen for the risk of age-related macular degeneration (AMD) at very early stages, macular pigment optical density (MPOD) and photoreceptor outer segment (PROS) length were analyzed. Thirty late AMD fellow eyes, which are at high risk and represent the predisease condition of AMD, were evaluated and compared with 30 age-matched control eyes without retinal diseases; there was no early AMD involvement in the AMD fellow eyes. MPOD was measured using MPS2® (M.E. Technica Co. Ltd., Tokyo, Japan), and PROS length was measured based on optical coherence tomography images. MPOD levels and PROS length in the AMD fellow eyes were significantly lower and shorter, respectively, than in control eyes. MPOD and PROS length were positively correlated in control eyes (R = 0.386; p = 0.035) but not in AMD fellow eyes. Twenty (67%) AMD fellow eyes met the criteria of MPOD < 0.65 and/or PROS length < 35 μm, while only five (17%) control eyes did. After adjusting for age and sex, AMD fellow eyes more frequently satisfied the definition (p < 0.001; 95% confidence interval, 3.50–60.4; odds ratio, 14.6). The combination of MPOD and PROS length may be a useful biomarker for screening predisease AMD patients, although further studies are required in this regard.

scholarly journals Macular pigment optical density in central serous chorioretinopathy

2021 ◽  
Vol 13 ◽  
pp. 251584142199719
Author(s):  
Burcu Polat Gultekin ◽  
Esra Sahli
Keyword(s):  
Confidence Interval ◽  
Optical Density ◽  
Central Serous Chorioretinopathy ◽  
Choroidal Thickness ◽  
Retinal Thickness ◽  
Macular Pigment ◽  
Central Retinal Thickness ◽  
Macular Pigment Optical Density ◽  
Chronic Central Serous Chorioretinopathy ◽  
Acute Central Serous Chorioretinopathy

Purpose: The aim of our study was to evaluate the macular pigment optical density in patients with acute and chronic central serous chorioretinopathy and to describe the association between central retinal thickness and choroidal thickness with the macular pigment optical density. Materials and Methods: Eyes with acute central serous chorioretinopathy and chronic central serous chorioretinopathy (patients, who were diagnosed as having disease activity for 6 months) were included in this study. Macular pigment was measured using the heterochromatic flicker technique of the MPS II device for both eyes in patients with acute and chronic central serous chorioretinopathy and in control subjects. Results: Twenty-seven eyes with acute central serous chorioretinopathy, 23 eyes with chronic central serous chorioretinopathy, and 25 control eyes were enrolled. The mean macular pigment optical density in chronic central serous chorioretinopathy (0.480 ± 0.16 density unit (95% confidence interval: 0.390–0.570) was found to be significantly lower than in the control eyes (0.571 ± 0.128 density unit) (95% confidence interval: 0.480–0.670) ( p = 0.007). In correlation analysis, no significant association was detected between the central retinal thickness, choroidal thickness, and macular pigment optical density values in central serous chorioretinopathy group ( p = 0.31, p = 0.71). Conclusion: Macular pigment optical density levels were significantly lower in chronic central serous chorioretinopathy patients than in controls, possibly due to degeneration of the neurosensorial retina, as a result of the long-term persistence of subretinal fluid. There was not a significant correlation between choroidal thickness and macular pigment optical density levels in central serous chorioretinopathy group.

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