Differential Effects of Costimulatory Pathway Modulation on Corneal Allograft Survival

2006 ◽  
Vol 47 (8) ◽  
pp. 3417 ◽  
Author(s):  
Martin P. Watson ◽  
Andrew J. T. George ◽  
Daniel F. P. Larkin
Keyword(s):  
Allograft Survival ◽  
Corneal Allograft ◽  
Differential Effects ◽  
Costimulatory Pathway

Influence of local and systemic CTLA4Ig gene transfer on corneal allograft survival

2006 ◽  
Vol 8 (4) ◽  
pp. 459-467 ◽  
Author(s):  
Nianqiao Gong ◽  
Uwe Pleyer ◽  
Jun Yang ◽  
Katrin Vogt ◽  
Marcelo Hill ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Allograft Survival ◽  
Corneal Allograft

Ripasudil zur antiangiogenen Therapie bei Keratoplastik

2021 ◽  
pp. 1-2
Author(s):  
Björn Bachmann
Keyword(s):  
Graft Survival ◽  
Immune Cell ◽  
Kinase Inhibitor ◽  
Healing Process ◽  
Corneal Transplantation ◽  
Inflammatory Factors ◽  
Wound Healing Process ◽  
Mrna Levels ◽  
Allograft Survival ◽  
Corneal Allograft

Corneal allograft survival is mediated by the variety of immunological reactions and wound healing process. Our aim was to explore the effects of topical administration of ripasudil, a selective Rho-associated coiled-coil protein kinase inhibitor, on corneal allograft survival. Ripasudil was administered to mice thrice a day after allogeneic corneal transplantation. Corneal graft survival, opacity, neovascularization, re-epithelization, immune cell infiltration, and mRNA levels of angiogenic and pro-inflammatory factors in the grafted cornea and draining lymph nodes (dLNs) were evaluated with slit-lamp microscopy, immunohistochemistry, flow cytometry, and polymerase chain reaction. Graft survival was significantly prolonged with lower graft opacity and neovascularization scores in 0.4% and 2.0% ripasudil-treated groups, and mRNA levels of angiogenic and pro-inflammatory factors in ripasudil-treated grafted corneas were reduced. Moreover, 0.4% and 2.0% ripasudil reduced CD45<sup>+</sup>-infiltrated leukocyte frequency, <i>Cd11b</i> and <i>Cd11c</i> mRNA levels, and the frequencies of mature dendritic cells, IFNγ-, and IL-17- producing CD4<sup>+</sup>T cells in the dLNs of recipients. Re-epithelization rate of the grafted cornea was significantly higher in the 0.4% and 2.0% ripasudil groups than in the control. Topically applied ripasudil prolonged graft survival by downregulating neovascularization and inflammation factors, while promoting corneal re-epithelization, suggesting that ripasudil may be useful for suppressing immunological rejection in corneal transplantation.

Effect of the Preservation-to-Surgery Interval on Corneal Allograft Survival in Low-Risk Patients

2007 ◽  
Vol 38 (6) ◽  
pp. 457-461 ◽  
Author(s):  
Selim Doganay ◽  
I. Fevzi Hepsen ◽  
Saim Yologlu ◽  
Hakan Demirtas
Keyword(s):  
Low Risk ◽  
Allograft Survival ◽  
Corneal Allograft ◽  
Risk Patients

scholarly journals VISTA Is Crucial for Corneal Allograft Survival and Maintenance of Immune Privilege

2019 ◽  
Vol 60 (15) ◽  
pp. 4958 ◽  
Author(s):  
Tomoyuki Kunishige ◽  
Hiroko Taniguchi ◽  
Tatsukuni Ohno ◽  
Miyuki Azuma ◽  
Junko Hori
Keyword(s):  
Immune Privilege ◽  
Allograft Survival ◽  
Corneal Allograft

Prolongation of Corneal Allograft Survival with Liposome-encapsulated Cyclosporine in the Rat Eye

Ophthalmology ◽  
1993 ◽  
Vol 100 (6) ◽  
pp. 890-896 ◽  
Author(s):  
Jessica K. Milani ◽  
Uwe Pleyer ◽  
Andres Dukes ◽  
H. Joseph Chou ◽  
Sabine Lutz ◽  
...  
Keyword(s):  
Allograft Survival ◽  
Corneal Allograft

scholarly journals Vasoactive Intestinal Peptide Promotes Corneal Allograft Survival

2018 ◽  
Vol 188 (9) ◽  
pp. 2016-2024 ◽  
Author(s):  
Vannarut Satitpitakul ◽  
Zhongmou Sun ◽  
Kunal Suri ◽  
Afsaneh Amouzegar ◽  
Kishore R. Katikireddy ◽  
...  
Keyword(s):  
Vasoactive Intestinal Peptide ◽  
Allograft Survival ◽  
Corneal Allograft

Immune regulatory effect of rapamycin and cyclosporine A on experimental corneal allograft survival

2009 ◽  
Vol 87 ◽  
pp. 0-0
Author(s):  
S STANOJLOVIC ◽  
S SCHLICKEISER ◽  
C APPELT ◽  
K VOGT ◽  
I SCHMITT-KNOSALLA ◽  
...  
Keyword(s):  
Cyclosporine A ◽  
Regulatory Effect ◽  
Allograft Survival ◽  
Corneal Allograft

The influence of inducible costimulator fusion protein (ICOSIg) gene transfer on corneal allograft survival

2007 ◽  
Vol 245 (10) ◽  
pp. 1515-1521 ◽  
Author(s):  
Daniel Fabian ◽  
Nianqiao Gong ◽  
Katrin Vogt ◽  
Hans-Dieter Volk ◽  
Uwe Pleyer ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Fusion Protein ◽  
Allograft Survival ◽  
Corneal Allograft ◽  
Inducible Costimulator
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