Nuclear Gene Expression Changes Due to Mitochondrial Dysfunction in ARPE-19 Cells: Implications for Age-Related Macular Degeneration

2005 ◽  
Vol 46 (5) ◽  
pp. 1765 ◽  
Author(s):  
Michael V. Miceli ◽  
S. Michal Jazwinski
Keyword(s):  
Gene Expression ◽  
Mitochondrial Dysfunction ◽  
Macular Degeneration ◽  
Nuclear Gene ◽  
Age Related Macular Degeneration ◽  
Nuclear Gene Expression ◽  
Age Related

scholarly journals Role of amyloid β-peptide in the pathogenesis of age-related macular degeneration

2021 ◽  
Vol 6 (1) ◽  
pp. e000774
Author(s):  
Minwei Wang ◽  
Shiqi Su ◽  
Shaoyun Jiang ◽  
Xinghuai Sun ◽  
Jiantao Wang
Keyword(s):  
Mitochondrial Dysfunction ◽  
Macular Degeneration ◽  
Vision Loss ◽  
Cell Structure ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Amyloid Β ◽  
Age Related Macular Degeneration ◽  
Amyloid Β Peptide ◽  
Age Related

Age-related macular degeneration (AMD) is the most common eye disease in elderly patients, which could lead to irreversible vision loss and blindness. Increasing evidence indicates that amyloid β-peptide (Aβ) might be associated with the pathogenesis of AMD. In this review, we would like to summarise the current findings in this field. The literature search was done from 1995 to Feb, 2021 with following keywords, ‘Amyloid β-peptide and age-related macular degeneration’, ‘Inflammation and age-related macular degeneration’, ‘Angiogenesis and age-related macular degeneration’, ‘Actin cytoskeleton and amyloid β-peptide’, ‘Mitochondrial dysfunction and amyloid β-peptide’, ‘Ribosomal dysregulation and amyloid β-peptide’ using search engines Pubmed, Google Scholar and Web of Science. Aβ congregates in subretinal drusen of patients with AMD and participates in the pathogenesis of AMD through enhancing inflammatory activity, inducing mitochondrial dysfunction, altering ribosomal function, regulating the lysosomal pathway, affecting RNA splicing, modulating angiogenesis and modifying cell structure in AMD. The methods targeting Aβ are shown to inhibit inflammatory signalling pathway and restore the function of retinal pigment epithelium cells and photoreceptor cells in the subretinal region. Targeting Aβ may provide a novel therapeutic strategy for AMD.

scholarly journals Effects of intravitreal ranibizumab on the untreated eye and systemic gene expression profile in age-related macular degeneration [Corrigendum]

2016 ◽  
pp. 775
Author(s):  
Katarzyna Michalska-Malecka ◽  
Adam Kabiesz ◽  
Małgorzata Kimsa ◽  
Barbara Strzałka-Mrozik ◽  
Maria Formińska-Kapuścik ◽  
...  
Keyword(s):  
Gene Expression ◽  
Macular Degeneration ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Age Related Macular Degeneration ◽  
Intravitreal Ranibizumab ◽  
Age Related

scholarly journals Effects of intravitreal ranibizumab on the untreated eye and systemic gene expression profile in age-related macular degeneration

2016 ◽  
pp. 357 ◽  
Author(s):  
Katarzyna Michalska-Malecka ◽  
Adam Kabiesz ◽  
Małgorzata Kimsa ◽  
Barbara Strzałka-Mrozik ◽  
Maria Formińska-Kapuścik ◽  
...  
Keyword(s):  
Gene Expression ◽  
Macular Degeneration ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Age Related Macular Degeneration ◽  
Intravitreal Ranibizumab ◽  
Age Related

scholarly journals Targeted Gene Candidates for Treatment and Early Diagnosis of Age-Related Macular Degeneration

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Emine Cinici ◽  
Ozge Caglar ◽  
Mehmet Enes Arslan ◽  
Nilay Dilekmen ◽  
Bahadır Utlu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Early Diagnosis ◽  
Macular Degeneration ◽  
Expression Analysis ◽  
Peripheral Blood ◽  
Gene Expression Analysis ◽  
Mononuclear Cells ◽  
Age Related Macular Degeneration ◽  
Pcr Analysis ◽  
Age Related

Age-related macular degeneration (AMD) is an eye disease that impairs the sharp and central vision need for daily activities. Recent advances in molecular biology research not only lead to a better understanding of the genetics and pathophysiology of AMD but also to the development of applications based on targeted gene expressions to treat the disease. Clarification of molecular pathways that causing to development and progression in dry and wet types of AMD needs comprehensive and comparative investigations in particular precious biopsies involving peripheral blood samples from the patients. Therefore, in this investigation, dry and wet types of AMD patients and healthy individuals were aimed at investigating in regard to targeted gene candidates by using gene expression analysis for the first time. 13 most potent candidate genes involved in neurodegeneration were selected via in silico approach and investigated through gene expression analysis to suggest new targets for disease therapy. For the analyses, 30 individuals (10 dry and 10 wet types AMD patients and 10 healthy people) were involved in the study. SYBR-Green based Real-Time PCR analysis was performed on isolated peripheral blood mononuclear cells (PBMCs) to analyze differentially expressed genes related to these cases. According to the investigations, only the CRP gene was found to be upregulated for both dry and wet disease types. When the downregulated genes were analyzed, it was found that 11 genes were commonly decreased for both dry and wet types in the aspect of expression pattern. From these genes, CFH, CX3CR1, FLT1, and TIMP3 were found to have the most downregulated gene expression properties for both diseases. From these results, it might be concluded that these common upregulated and downregulated genes could be used as targets for early diagnosis and treatment for AMD.

Noninvasive Imaging of Mitochondrial Dysfunction in Dry Age-Related Macular Degeneration

2012 ◽  
Vol 43 (5) ◽  
pp. 358-365 ◽  
Author(s):  
Matthew G. Field ◽  
Grant M. Comer ◽  
Takahiro Kawaji ◽  
Howard R. Petty ◽  
Victor M. Elner
Keyword(s):  
Mitochondrial Dysfunction ◽  
Macular Degeneration ◽  
Noninvasive Imaging ◽  
Age Related Macular Degeneration ◽  
Age Related

scholarly journals Effects of Mitochondrial-Derived Peptides (MDPs) on Mitochondrial and Cellular Health in AMD

Cells ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 1102 ◽  
Author(s):  
Sonali Nashine ◽  
M. Cristina Kenney
Keyword(s):  
Mitochondrial Dysfunction ◽  
Macular Degeneration ◽  
Therapeutic Targets ◽  
Mechanisms Of Action ◽  
Age Related Macular Degeneration ◽  
Age Related

Substantive evidence demonstrates the contribution of mitochondrial dysfunction in the etiology and pathogenesis of Age-related Macular Degeneration (AMD). Recently, extensive characterization of Mitochondrial-Derived Peptides (MDPs) has revealed their cytoprotective role in several diseases, including AMD. Here we summarize the varied effects of MDPs on cellular and mitochondrial health, which establish the merit of MDPs as therapeutic targets for AMD. We argue that further research to delve into the mechanisms of action and delivery of MDPs may advance the field of AMD therapy.

scholarly journals THE HOMING TRIAL: A RETROSPECTIVE PILOT STUDY ON THE EFFICACY OF PERSONALIZED BIOIDENTICAL HORMONE, DIETARY SUPPLEMENT AND NUTRITION CARE PLANS FOR AGE-RELATED MACULAR DEGENERATION (AMD)

2021 ◽  
Vol 5 (4) ◽  
Author(s):  
George W. Rozakis ◽  
Brian A. Bakke
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Visual Acuity ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Control Group ◽  
Care Plans ◽  
Age Related ◽  
Dry Amd ◽  
Wet Amd

The objective of the Hormones, Oxidative stress, Methylation, Inflammation and Gene expression (HOMING) trial was to assess the efficacy of personalized bio identical hormone, dietary supplement and nutritional care plans on dry and wet Age-related Macular Degeneration (AMD) outcomes.  We evaluated 220 Age-related Macular Degeneration (AMD) patients that followed a personalized clinical care plan for up to 9 months.   The care plans consisted of bio identical hormones, dietary supplements and nutrition recommendations with the objective to improve lab and clinical measurements linked to oxidative stress, inflammation and gene expression.  Serum concentrations of CRP, HbA1c and homocysteine responded favorably to the HOMING protocol with full program compliance. Sixty percent (42/70) of wet AMD patients reported improvement in visual acuity and/or a reduction in the frequency of anti-VEGF injections during the study period.  Forty eight percent (44/92) of dry AMD patients reported improvement in visual acuity during the study period.  Nine percent (4/45) patients reported improvement in visual acuity in the dry AMD control group and no (0/13) wet AMD patients in the control group reported improvement.  Six percent (4/70) of wet AMD patients reported that their vision declined and/or that their F frequency increased during the study period.  Five percent (4/92) of dry AMD patients reported that their vision was worse.  Keywords:  Bio identical Hormones, Oxidative stress, Methylation, Inflammation, Gene Expression, Nutrition and AMD.

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