scholarly journals Family Aggregation of High Myopia: Estimation of the Sibling Recurrence Risk Ratio

2004 ◽  
Vol 45 (9) ◽  
pp. 2873 ◽  
Author(s):  
Jane E. Farbrother ◽  
George Kirov ◽  
Michael J. Owen ◽  
Jeremy A. Guggenheim
Keyword(s):  
Risk Ratio ◽  
High Myopia ◽  
Recurrence Risk ◽  
Recurrence Risk Ratio ◽  
Family Aggregation ◽  
Sibling Recurrence Risk

Population-Based Estimate of the Sibling Recurrence Risk Ratio for Rhegmatogenous Retinal Detachment

2011 ◽  
Vol 52 (5) ◽  
pp. 2551 ◽  
Author(s):  
Danny Mitry ◽  
Linda Williams ◽  
David G. Charteris ◽  
Brian W. Fleck ◽  
Alan F. Wright ◽  
...  
Keyword(s):  
Retinal Detachment ◽  
Risk Ratio ◽  
Rhegmatogenous Retinal Detachment ◽  
Recurrence Risk ◽  
Population Based ◽  
Recurrence Risk Ratio ◽  
Sibling Recurrence Risk

scholarly journals Sibling recurrence risk ratio analysis of the metabolic syndrome and its components over time

BMC Genetics ◽  
2003 ◽  
Vol 4 (Suppl 1) ◽  
pp. S33 ◽  
Author(s):  
Wei J Chen ◽  
Pi-Hua Liu ◽  
Yen-Yi Ho ◽  
Kuo-Liong Chien ◽  
Min-Tzu Lo ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Risk Ratio ◽  
Recurrence Risk ◽  
Ratio Analysis ◽  
The Metabolic Syndrome ◽  
Recurrence Risk Ratio ◽  
Sibling Recurrence Risk ◽  
Over Time

Recurrence Risk Ratio

2013 ◽  
pp. 1633-1633
Author(s):  
Kristine M. Molina ◽  
Kristine M. Molina ◽  
Heather Honoré Goltz ◽  
Marc A. Kowalkouski ◽  
Stacey L. Hart ◽  
...  
Keyword(s):  
Risk Ratio ◽  
Recurrence Risk ◽  
Recurrence Risk Ratio

Comparison of circulating tumor cells (CTC) and disseminated tumor cells (DTC) in patients with colorectal carcinoma for a predictive marker for tumor recurrence.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e14548-e14548
Author(s):  
Hideyasu Sakihama ◽  
Nozomi Kobayashi ◽  
Nozomi Minagawa ◽  
Tatsushi Shimokuni ◽  
Shigenori Homma ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Tumor Cells ◽  
Risk Ratio ◽  
Tumor Recurrence ◽  
Significant Risk ◽  
Predictive Marker ◽  
Recurrence Risk ◽  
Postoperative Recurrence ◽  
Recurrence Rates ◽  
Recurrence Risk Ratio

e14548 Background: Although the presence of CTC or DTC is proposed as a pridictive or a prognostic marker in the management of colorectal carcinoma patients, it is still well unknown what is different of both types of cells. The aim of this study is to compare CTC and DTC as a predictive marker for tumor recurrence by magnetic activated cell sorting system. Methods: Peripheral blood (PB) samples (n=139) and bone marrow (BM) samples (n=41) were preoperatively collected from colorectal carcinoma patients between February 2009 and March 2012. PB samples were obtainable from all patients who provided their BM samples (n=41). Enrichment of CTC was performed by direct immunomagnetic labeling of EpCAM + cells in PB. Enrichment of DTC was done by negative selection of CD45+cells. Subsequently, double immunofluorescences staining for cytokeratin and CD45 was performed to detect CTC or DTC. PB samples from 20 healthy volunteers and BM samples from 3 patients with benign disease were used as controls. Median follow-up time is 28.5 months (range 10-44). Written informed consent was obtained from all enrolled patients. Results: Preoperative positive rates of CTC and DTC were 20.9% (29/139) and 29.3% (12/41), respectively. No CTC or DTC was found in the control groups. In DTC+patients, only 4 patients were positive for CTC (33.3%), whereas 31% of DTC- patients had CTC. We found 13 patients who experienced postoperative recurrence among 139 patients, 7 patients of whom were CTC positive (53.8%). There is a significant higher incidence of recurrence in CTC+patients (risk ratio=4.4, p<0.01). As for DTC, we found 5 patients with recurrence in 41 patients, 4 patients of whom were DTC positive (80%). DTC+ patients have a significant risk of recurrence (risk ratio=9.7, p=0.01). The relationship of CTC / DTC status and the recurrence rates is as follows: 50 % in CTC+/DTC+ patients (2/4); 11.1% in CTC+/DTC- patients (1/9); 25% in CTC-/DTC+ patients (2/8); 0% in CTC-/DTC-patients (0/20). Conclusions: DTC status is more predictive for postoperative recurrence than CTC status. The combination of CTC and DTC analysis might predict recurrence risk more accurately than either of the two analyses.

scholarly journals Familial Intracranial Aneurysms: Recurrence Risk and Accidental Aggregation Study

1997 ◽  
Vol 24 (04) ◽  
pp. 326-331 ◽  
Author(s):  
Jean Mathieu ◽  
Gilles Hébert ◽  
Louis Pérusse ◽  
Claude Prévost ◽  
Léo Cantin ◽  
...  
Keyword(s):  
Risk Ratio ◽  
Genetic Predisposition ◽  
Intracranial Aneurysms ◽  
Familial Aggregation ◽  
Recurrence Risk ◽  
Population Based ◽  
Degree Relative ◽  
Ruptured Intracranial Aneurysm ◽  
Recurrence Risk Ratio ◽  
Risk Of Disease

ABSTRACT:Background:The Saguenay-Lac-Saint-Jean (SLSJ) region is a geographically isolated area (population 285,955) located in the Northeastern part of the Province of Quebec, Canada. Using a population-based register, the genealogical reconstruction of 502 individuals with ruptured intracranial aneurysm (RIA) showed a familial aggregation (the presence of aneurysm in two or more first- to third-degree relatives) for 144 (28.7%) of them; this proportion is much higher than reported elsewhere.Objective:In order to assess the genetic predisposition to RIA in the SLSJ population, the objective of the present study is to compare familial and non-familial cases and to provide an estimate of the recurrence risk ratio for siblings.Results:The age at the time of rupture, the number of intracranial aneurysms for each patient and the location of RIAs were not statistically different in the familial versus the non-familial group. Of the 3449 siblings, 20 (0.58%) had suffered a RIA. The recurrence risk ratio calculated for siblings (defined as the risk of disease among siblings divided by the estimated population prevalence) is 1.6 (CI 95% 1.0 - 2.4). In other respects, we observed very large kinships in the SLSJ population, with an average number of siblings of 7.2 (SD ± 3.4), ranging from 0 to 17 individuals. With such large families and on the basis of chance alone, we expected 31.3% of the patients to have at least one first- to third-degree relative with RIA.Conclusion:These data show that siblings of patients with RIA in the SLSJ population have a greater risk of RIA than the general population. Nevertheless, the largest part of the familial occurrence observed in the SLSJ region can be explained by accidental aggregation, due to large kinships. We propose that, in this population, an underlying genetic predisposition must be suspected only when three or more cases of RIA are identified among first- to third-degree relatives.

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