In Vivo Antiviral Efficacy of a Dipeptide Acyclovir Prodrug, Val-Val-Acyclovir, against HSV-1 Epithelial and Stromal Keratitis in the Rabbit Eye Model

2003 ◽  
Vol 44 (6) ◽  
pp. 2529 ◽  
Author(s):  
Banmeet S. Anand ◽  
James M. Hill ◽  
Surajit Dey ◽  
Koichi Maruyama ◽  
Partha S. Bhattacharjee ◽  
...  
Keyword(s):  
Eye Model ◽  
Rabbit Eye ◽  
Antiviral Efficacy ◽  
Stromal Keratitis ◽  
Hsv 1

scholarly journals In vivo and in vitro reactivation impairment of a herpes simplex virus type 1 latency-associated transcript variant in a rabbit eye model.

1991 ◽  
Vol 65 (12) ◽  
pp. 6989-6993 ◽  
Author(s):  
M D Trousdale ◽  
I Steiner ◽  
J G Spivack ◽  
S L Deshmane ◽  
S M Brown ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Eye Model ◽  
Rabbit Eye ◽  
Simplex Virus

scholarly journals Healing of Ocular Herpetic Disease Following Treatment With an Engineered FGF-1 Is Associated With Increased Corneal Anti-Inflammatory M2 Macrophages

2021 ◽  
Vol 12 ◽  
Author(s):  
Nisha R. Dhanushkodi ◽  
Ruchi Srivastava ◽  
Pierre-Gregoire A. Coulon ◽  
Swayam Prakash ◽  
Soumyabrata Roy ◽  
...  
Keyword(s):  
Macrophage Polarization ◽  
M2 Macrophage ◽  
Herpes Simplex Virus 1 ◽  
Cytokines And Chemokines ◽  
Latently Infected ◽  
Stromal Keratitis ◽  
Simplex Virus ◽  
Hsv 1

Herpes simplex virus 1 (HSV-1) infects the cornea and caused blinding ocular disease. In the present study, we evaluated whether and how a novel engineered version of fibroblast growth factor-1 (FGF-1), designated as TTHX1114, would reduce the severity of HSV-1-induced and recurrent ocular herpes in the mouse model. The efficacy of TTHX1114 against corneal keratopathy was assessed in B6 mice following corneal infection with HSV-1, strain McKrae. Starting day one post infection (PI), mice received TTHX1114 for 14 days. The severity of primary stromal keratitis and blepharitis were monitored up to 28 days PI. Inflammatory cell infiltrating infected corneas were characterized up to day 21 PI. The severity of recurrent herpetic disease was quantified in latently infected B6 mice up to 30 days post-UVB corneal exposure. The effect of TTHX1114 on M1 and M2 macrophage polarization was determined in vivo in mice and in vitro on primary human monocytes-derived macrophages. Compared to HSV-1 infected non-treated mice, the infected and TTHX1114 treated mice exhibited significant reduction of primary and recurrent stromal keratitis and blepharitis, without affecting virus corneal replication. The therapeutic effect of TTHX1114 was associated with a significant decrease in the frequency of M1 macrophages infiltrating the cornea, which expressed significantly lower levels of pro-inflammatory cytokines and chemokines. This polarization toward M2 phenotype was confirmed in vitro on human primary macrophages. This pre-clinical finding suggests use of this engineered FGF-1 as a novel immunotherapeutic regimen to reduce primary and recurrent HSV-1-induced corneal disease in the clinic.

Correction to: In Vivo Evaluation of a Biodegradable Donut-Shaped Minitablet for Prolonged Posterior Segment Drug Delivery in the Rabbit Eye Model. J Pharm Sci 100:1819–1832

2011 ◽  
Vol 100 (8) ◽  
pp. 3539
Author(s):  
Yahya E. Choonara ◽  
Viness Pillay ◽  
Michael P. Danckwerts ◽  
Trevor R. Carmichael ◽  
Leith C.R. Meyer ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Posterior Segment ◽  
In Vivo Evaluation ◽  
Eye Model ◽  
Rabbit Eye

805-nm diode-laser-induced release of liposome-encapsulated dye for quantification of chorioretinal thermal damage: in-vivo study on a rabbit eye model

1998 ◽  
Author(s):  
Serge R. Mordon ◽  
Thomas Desmettre ◽  
Jean-Marie Devoisselle ◽  
Sylvie Begu ◽  
Valerie A. Mitchell
Keyword(s):  
Diode Laser ◽  
Thermal Damage ◽  
In Vivo Study ◽  
Eye Model ◽  
Rabbit Eye

In Vivo Evaluation of a Biodegradable Donut-Shaped Minitablet for Prolonged Posterior Segment Drug Delivery in the Rabbit Eye Model

2011 ◽  
Vol 100 (5) ◽  
pp. 1819-1832 ◽  
Author(s):  
Yahya E. Choonara ◽  
Viness Pillay ◽  
Trevor R. Carmichael ◽  
Leith C.R. Meyer ◽  
Lisa C. Du Toit ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Posterior Segment ◽  
In Vivo Evaluation ◽  
Eye Model ◽  
Rabbit Eye

scholarly journals Confocal Microscopic Analysis of a Rabbit Eye Model of High-Incidence Recurrent Herpes Stromal Keratitis

Cornea ◽  
2016 ◽  
Vol 35 (1) ◽  
pp. 81-88 ◽  
Author(s):  
James V. Jester ◽  
Naoyuki Morishige ◽  
Lbachir BenMohamed ◽  
Donald J. Brown ◽  
Nelson Osorio ◽  
...  
Keyword(s):  
Microscopic Analysis ◽  
Eye Model ◽  
Rabbit Eye ◽  
High Incidence ◽  
Recurrent Herpes ◽  
Stromal Keratitis ◽  
Herpes Stromal Keratitis

scholarly journals The antimicrobial agent C31G is effective for therapy for HSV-1 ocular keratitis in the rabbit eye model

2013 ◽  
Vol 100 (1) ◽  
pp. 14-19 ◽  
Author(s):  
James M. Hill ◽  
Ethan M. Stern ◽  
Partha S. Bhattacharjee ◽  
Daniel Malamud ◽  
Christian Clement ◽  
...  
Keyword(s):  
Antimicrobial Agent ◽  
Eye Model ◽  
Rabbit Eye ◽  
Ocular Keratitis ◽  
Hsv 1
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