Role of Connective Tissue Growth Factor in the Pathogenesis of Conjunctival Scarring in Ocular Cicatricial Pemphigoid

2003 ◽  
Vol 44 (5) ◽  
pp. 1998 ◽  
Author(s):  
Mohammed S. Razzaque ◽  
C. Stephen Foster ◽  
A. Razzaque Ahmed
Keyword(s):  
Growth Factor ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Tissue Growth ◽  
Cicatricial Pemphigoid ◽  
Ocular Cicatricial Pemphigoid

scholarly journals The pathogenic role of connective tissue growth factor in osteoarthritis

2019 ◽  
Vol 39 (7) ◽  
Author(s):  
Min Tu ◽  
Yao Yao ◽  
Feng Hua Qiao ◽  
Li Wang
Keyword(s):  
Growth Factor ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Therapeutic Target ◽  
Surface Damage ◽  
Nuclear Factor Κb ◽  
Cartilage Degradation ◽  
Tissue Growth ◽  
Cartilage Homeostasis

Abstract Osteoarthritis (OA) is the most common form of arthritis, and connective tissue growth factor (CTGF) is found to be up-regulated in adjacent areas of cartilage surface damage. CTGF is present in osteophytes of late stage OA. In the present study, we have reviewed association of CTGF in the development and progression of OA and the potential effects of CTGF as a therapeutic agent for the treatment of OA. We have reviewed the recent articles on CTGF and OA in databases like PubMed, google scholar, and SCOPUS and collected the information for the articles. CTGF is usually up-regulated in synovial fluid of OA that stimulates the production of inflammatory cytokines. CTGF also activates nuclear factor-κB, increases the production of chemokines and cytokines, and up-regulates matrix metalloproteinases-3 (MMP-3) that in turn leads to the reduction in proteoglycan contents in joint cartilage. Consequently, cartilage homeostasis is imbalanced that might contribute to the pathogenesis of OA by developing synovial inflammation and cartilage degradation. CTGF might serve as a useful biomarker for the prognosis and treatment of OA, and recent studies have taken attempt to use CTGF as therapeutic target of OA. However, more investigations with clinical trials are necessary to validate the possibility of use of CTGF as a biomarker in OA diagnosis and therapeutic target for OA treatment.

scholarly journals Role of Connective Tissue Growth Factor in the Retinal Vasculature during Development and Ischemia

2011 ◽  
Vol 52 (12) ◽  
pp. 8701 ◽  
Author(s):  
Liya Pi ◽  
Huiming Xia ◽  
Jianwen Liu ◽  
Anitha K. Shenoy ◽  
William W. Hauswirth ◽  
...  
Keyword(s):  
Growth Factor ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Tissue Growth ◽  
Retinal Vasculature

Role of prostaglandin E2 EP receptors and cAMP in the expression of connective tissue growth factor

2002 ◽  
Vol 404 (2) ◽  
pp. 302-308 ◽  
Author(s):  
Jun Yu ◽  
Gregory N Prado ◽  
Barbara Schreiber ◽  
Paul Polgar ◽  
Peter Polgar ◽  
...  
Keyword(s):  
Growth Factor ◽  
Connective Tissue ◽  
Prostaglandin E2 ◽  
Connective Tissue Growth Factor ◽  
Tissue Growth ◽  
Ep Receptors

Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen

2009 ◽  
Vol 60 (7) ◽  
pp. 2142-2155 ◽  
Author(s):  
Markella Ponticos ◽  
Alan M. Holmes ◽  
Xu Shi-Wen ◽  
Patricia Leoni ◽  
Korsa Khan ◽  
...  
Keyword(s):  
Growth Factor ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Transcriptional Activation ◽  
Lung Fibrosis ◽  
Type I Collagen ◽  
Tissue Growth ◽  
Pivotal Role ◽  
Type I
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