Susceptibility to Retinal Light Damage in Transgenic Rats with Rhodopsin Mutations

2003 ◽  
Vol 44 (2) ◽  
pp. 486 ◽  
Author(s):  
Daniel T. Organisciak ◽  
Ruth M. Darrow ◽  
Linda Barsalou ◽  
R. Krishnan Kutty ◽  
Barbara Wiggert
Keyword(s):  
Light Damage ◽  
Transgenic Rats ◽  
Retinal Light Damage ◽  
Rhodopsin Mutations

Sulforaphane Induces Thioredoxin through the Antioxidant-Responsive Element and Attenuates Retinal Light Damage in Mice

2005 ◽  
Vol 46 (3) ◽  
pp. 979 ◽  
Author(s):  
Masaki Tanito ◽  
Hiroshi Masutani ◽  
Yong-Chul Kim ◽  
Mai Nishikawa ◽  
Akihiro Ohira ◽  
...  
Keyword(s):  
Light Damage ◽  
Retinal Light Damage ◽  
Responsive Element ◽  
Antioxidant Responsive Element

Evidence of Retinal Light Damage in Rana cascadae: A Declining Amphibian Species

Copeia ◽  
1998 ◽  
Vol 1998 (4) ◽  
pp. 906 ◽  
Author(s):  
Katherine V. Fite ◽  
Andrew Blaustein ◽  
Lynn Bengston ◽  
Heather E. Hewitt
Keyword(s):  
Light Damage ◽  
Amphibian Species ◽  
Retinal Light Damage ◽  
Rana Cascadae

The role of ocular pigmentation in protecting against retinal light damage

1980 ◽  
Vol 20 (12) ◽  
pp. 1127-1131 ◽  
Author(s):  
L.M. Rapp ◽  
T.P. Williams
Keyword(s):  
Light Damage ◽  
Retinal Light Damage

Visual thresholds in mice: Comparison of retinal light damage and hypopigmentation

1993 ◽  
Vol 10 (5) ◽  
pp. 931-938 ◽  
Author(s):  
Jennifer M. Hayes ◽  
Grant W. Balkema
Keyword(s):  
Outer Nuclear Layer ◽  
Constant Light ◽  
Light Damage ◽  
Virtual Absence ◽  
Retinal Light Damage ◽  
Cell Counts ◽  
Similar Threshold ◽  
Albino Mice ◽  
Thin Plastic ◽  
Light History

AbstractIn previous electrophysiological experiments from hypopigmented animals (mice, rats, rabbits), single-unit recordings from both retinal ganglion axons and cells in the superior colliculus have demonstrated an increase in threshold in the dark-adapted state which is roughly proportional to the animal's ocular melanin concentration. We have examined the thresholds in hypopigmented mice by using a behavioral water maze screening test and found similar threshold elevations to the electrophysiology. In the present study, we investigated the contribution of retinal light damage to the threshold elevation in an albino mouse strain which is relatively resistant to light damage (C57BL/6J c2J/c2J) and mice with profound retinal degeneration (C57BL/6J rd/rd).Black or albino littermates (C57BL/6J + / c2J or c2J / c2J) were placed in either constant light (350 cd/m2) or dim cycling light (0.001 cd/m2) for 21 days before testing. The normally pigmented animals had thresholds of 1.00 × 10−5 cd/m2 regardless of their light history. The albino mice (c2J/c2J) maintained in constant light had a slight 0.30 log unit elevation compared to their controls that were maintained in dim cycling light 6.3 × 10−4 cd/m2 (similar to previously published reports).We examined the retinal morphology of representative animals in semi-thin plastic sections. We could not detect any light damage (overall morphology or cell counts in the outer-nuclear layer) in either the normally pigmented animals or the albino mice (c2J/c2J) maintained in dim cycling light. We found extensive light damage in the albino mice (c2J/c2J) maintained in constant light (virtual absence of photoreceptor outersegments) that corresponded to the slight elevation in threshold. We conclude that the elevation in threshold found in albino mice (c2J/c2J) maintained in dim cycling light is not the result of light damage. These results support our previous findings that the sensitivity defect in hypopigmented animals is proportional to the degree of ocular hypopigmentation.

Retinal light-damage in albino rats: Lysosomal enzymes, rhodopsin, and age

1985 ◽  
Vol 41 (3) ◽  
pp. 275-284 ◽  
Author(s):  
John S. Penn ◽  
Barbara N. Baker ◽  
Alice G. Howard ◽  
Theodore P. Williams
Keyword(s):  
Lysosomal Enzymes ◽  
Albino Rats ◽  
Light Damage ◽  
Retinal Light Damage

Role of heat shock protein (HSP) in retinal light damage

1992 ◽  
Vol 55 ◽  
pp. 131
Author(s):  
M. Tytell ◽  
C.R. Hollman ◽  
D.J. Gower
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Light Damage ◽  
Retinal Light Damage

Upregulation of SOX9 in Glial (Müller) cells in retinal light damage of rats

2013 ◽  
Vol 556 ◽  
pp. 140-145 ◽  
Author(s):  
Xin Wang ◽  
Jiawen Fan ◽  
Meng Zhang ◽  
Yingqin Ni ◽  
Gezhi Xu
Keyword(s):  
Müller Cells ◽  
Muller Cells ◽  
Light Damage ◽  
Retinal Light Damage
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