scholarly journals Superior colliculus (SC) neural activity codes visually guided head-unrestrained gaze movements in retinal coordinates

2010 ◽  
Vol 7 (9) ◽  
pp. 316-316
Author(s):  
J. DeSouza ◽  
G. Blohm ◽  
X. Yan ◽  
H. Wang ◽  
J. D. Crawford
Keyword(s):  
Superior Colliculus ◽  
Neural Activity ◽  
Visually Guided

Effects of low-frequency stimulation of the superior colliculus on spontaneous and visually guided saccades

1993 ◽  
Vol 69 (3) ◽  
pp. 953-964 ◽  
Author(s):  
P. W. Glimcher ◽  
D. L. Sparks
Keyword(s):  
Superior Colliculus ◽  
Time Course ◽  
Low Frequency ◽  
Arbitrary Point ◽  
Visually Guided ◽  
Spontaneous Movements ◽  
Low Frequency Stimulation ◽  
Frequency Stimulation ◽  
Stimulation Current ◽  
Stimulation Of

1. The first experiment of this study determined the effects of low-frequency stimulation of the monkey superior colliculus on spontaneous saccades in the dark. Stimulation trains, subthreshold for eliciting short-latency fixed-vector saccades, were highly effective at biasing the metrics (direction and amplitude) of spontaneous movements. During low-frequency stimulation, the distribution of saccade metrics was biased toward the direction and amplitude of movements induced by suprathreshold stimulation of the same collicular location. 2. Low-frequency stimulation biased the distribution of saccade metrics but did not initiate movements. The distribution of intervals between stimulation onset and the onset of the next saccade did not differ significantly from the distribution of intervals between an arbitrary point in time and the onset of the next saccade under unstimulated conditions. 3. Results of our second experiment indicate that low-frequency stimulation also influenced the metrics of visually guided saccades. The magnitude of the stimulation-induced bias increased as stimulation current or frequency was increased. 4. The time course of these effects was analyzed by terminating stimulation immediately before, during, or after visually guided saccades. Stimulation trains terminated at the onset of a movement were as effective as stimulation trains that continued throughout the movement. No effects were observed if stimulation ended 40–60 ms before the movement began. 5. These results show that low-frequency collicular stimulation can influence the direction and amplitude of spontaneous or visually guided saccades without initiating a movement. These data are compatible with the hypothesis that the collicular activity responsible for specifying the horizontal and vertical amplitude of a saccade differs from the type of collicular activity that initiates a saccade.

Effects of Local Nicotinic Activation of the Superior Colliculus on Saccades in Monkeys

2005 ◽  
Vol 93 (1) ◽  
pp. 519-534 ◽  
Author(s):  
Masayuki Watanabe ◽  
Yasushi Kobayashi ◽  
Yuka Inoue ◽  
Tadashi Isa
Keyword(s):  
Superior Colliculus ◽  
Reaction Times ◽  
Low Frequency ◽  
Visually Guided ◽  
Population Activity ◽  
Affected Area ◽  
Movement Field ◽  
Neural Interactions ◽  
Restricted Region

To examine the role of competitive and cooperative neural interactions within the intermediate layer of superior colliculus (SC), we elevated the basal SC neuronal activity by locally injecting a cholinergic agonist nicotine and analyzed its effects on saccade performance. After microinjection, spontaneous saccades were directed toward the movement field of neurons at the injection site (affected area). For visually guided saccades, reaction times were decreased when targets were presented close to the affected area. However, when visual targets were presented remote from the affected area, reaction times were not increased regardless of the rostrocaudal level of the injection sites. The endpoints of visually guided saccades were biased toward the affected area when targets were presented close to the affected area. After this endpoint effect diminished, the trajectories of visually guided saccades remained modestly curved toward the affected area. Compared with the effects on endpoints, the effects on reaction times were more localized to the targets close to the affected area. These results are consistent with a model that saccades are triggered by the activities of neurons within a restricted region, and the endpoints and trajectories of the saccades are determined by the widespread population activity in the SC. However, because increased reaction times were not observed for saccades toward targets remote from the affected area, inhibitory interactions in the SC may not be strong enough to shape the spatial distribution of the low-frequency preparatory activities in the SC.

Injection of Nicotine Into the Superior Colliculus Facilitates Occurrence of Express Saccades in Monkeys

1999 ◽  
Vol 82 (3) ◽  
pp. 1642-1646 ◽  
Author(s):  
Hiroshi Aizawa ◽  
Yasushi Kobayashi ◽  
Masaru Yamamoto ◽  
Tadashi Isa
Keyword(s):  
Superior Colliculus ◽  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Marked Change ◽  
Major Change ◽  
Visually Guided ◽  
Express Saccades ◽  
Macaque Monkeys ◽  
The Relationship

To clarify the role of cholinergic inputs to the intermediate layer of the superior colliculus (SC), we examined the effect of microinjection of nicotine into the SC on visually guided saccades in macaque monkeys. After injection of 0.4–2 μl of 1–100 mM nicotine into the SC, frequency of extremely short latency saccades (express saccades; reaction time = 70–120 ms) dramatically increased, for the saccades the direction and amplitude of which were represented at the location of the injection site on the collicular map. However, no marked change was observed for the relationship between the peak velocities and the amplitudes of saccades. These results suggested that activation of nicotinic acetylcholine receptors in the SC can facilitate initiation but causes no major change in dynamics of visually guided saccades.

Modified saccades evoked by stimulation of the macaque superior colliculus account for properties of the resettable integrator

1995 ◽  
Vol 73 (4) ◽  
pp. 1724-1728 ◽  
Author(s):  
A. A. Kustov ◽  
D. L. Robinson
Keyword(s):  
Superior Colliculus ◽  
Pulse Signal ◽  
Good Evidence ◽  
Visually Guided ◽  
Saccadic System ◽  
Time Period ◽  
Motor Error ◽  
Stimulation Of

1. Models of the saccadic system propose that there is an integration of the pulse signal, and there is good evidence that the integrator is reset gradually (Nichols and Sparks 1994, 1995). Other studies of the superior collicular contribution to the saccadic system have proposed a sensory, not motor, nature for its signal. 2. To test experimentally the resetting of the integrator and the nature of the collicular signal, we electrically stimulated the superior colliculus during periods of fixation and during the course of visually guided saccades. Trains of stimuli which were presented during periods of fixation evoked saccades with fixed vectors. Identical stimulation at the beginning of a visually guided saccade evoked saccades whose direction was rotated and amplitude extended from the fixed vector. The direction of the rotation was opposite that of the visually guided saccade, and the magnitude of this rotation could be as large as 80 degrees. 3. Stimulation which was applied at progressively later times during the visually guided saccade, evoked saccades with progressively smaller rotations and progressively less elongations. The time period during which saccades were modified persisted beyond the end of the visually guided saccade, when the eyes were stationary. Thus, we confirm the previous findings (Nichols and Sparks 1994, 1995; Robinson, 1972), that the end of the saccade is not a period of quiescence within the oculomotor pathways. 4. Our results confirm that the resetting of the integration of the saccade signal is gradual rather than abrupt. Furthermore, these data suggest that the superior colliculus signals a motor error.

scholarly journals Neuromodulation of Whisking Related Neural Activity in Superior Colliculus

2014 ◽  
Vol 34 (22) ◽  
pp. 7683-7695 ◽  
Author(s):  
T. Bezdudnaya ◽  
M. A. Castro-Alamancos
Keyword(s):  
Superior Colliculus ◽  
Neural Activity

scholarly journals Why we see things the way we do: evidence for a wholly empirical strategy of vision

2001 ◽  
Vol 356 (1407) ◽  
pp. 285-297 ◽  
Author(s):  
Dale Purves ◽  
R. Beau Lotto ◽  
S. Mark Williams ◽  
Surajit Nundy ◽  
Zhiyong Yang
Keyword(s):  
Physical Properties ◽  
Conceptual Framework ◽  
Neural Activity ◽  
Visually Guided ◽  
Operational Strategy ◽  
The Past ◽  
Ambiguous Stimuli ◽  
The Way

Many otherwise puzzling aspects of the way we see brightness, colour, orientation and motion can be understood in wholly empirical terms. The evidence reviewed here leads to the conclusion that visual percepts are based on patterns of reflex neural activity shaped entirely by the past success (or failure) of visually guided behaviour in response to the same or a similar retinal stimulus. As a result, the images we see accord with what the sources of the stimuli have typically turned out to be, rather than with the physical properties of the relevant objects. If vision does indeed depend upon this operational strategy to generate optimally useful perceptions of inevitably ambiguous stimuli, then the underlying neurobiological processes will eventually need to be understood within this conceptual framework.

Movement of neural activity on the superior colliculus motor map during gaze shifts

Science ◽  
1991 ◽  
Vol 251 (4999) ◽  
pp. 1358-1360 ◽  
Author(s):  
D. Munoz ◽  
D Pelisson ◽  
D Guitton
Keyword(s):  
Superior Colliculus ◽  
Neural Activity ◽  
Gaze Shifts

The role of the superior colliculus in visually guided locomotion and visual orienting in the hamster

1980 ◽  
Vol 8 (1) ◽  
pp. 20-28 ◽  
Author(s):  
Elizabeth Mort ◽  
Sara Cairns ◽  
Helen Hersch ◽  
Barbara Finlay
Keyword(s):  
Superior Colliculus ◽  
Visually Guided ◽  
Visual Orienting
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