scholarly journals Duration estimation is affected by stimulus magnitude information in non-temporal dimensions

2010 ◽  
Vol 6 (6) ◽  
pp. 1009-1009
Author(s):  
X. Chen ◽  
B. Xuan ◽  
D. Zhang ◽  
S. He
Keyword(s):  
Stimulus Magnitude ◽  
Temporal Dimensions ◽  
Duration Estimation

Improving time duration estimation with training on working memory

2012 ◽  
Author(s):  
Yoshihiro S. Okazaki ◽  
Yukio Tsuchida ◽  
Masamichi Yuzawa ◽  
Keigo Minakuchi ◽  
Nozomi Notsuyama ◽  
...  
Keyword(s):  
Working Memory ◽  
Time Duration ◽  
Duration Estimation

An Arrival Time and Duration Estimation of a Signal

2000 ◽  
Vol 54 (8-9) ◽  
pp. 122-133
Author(s):  
Andrey Pavlovich Trifonov ◽  
Yurii Eduardovich Korchagin
Keyword(s):  
Arrival Time ◽  
Duration Estimation

The Whole Self

2018 ◽  
Author(s):  
George Pattison
Keyword(s):  
The Self ◽  
Present Moment ◽  
Christian Spirituality ◽  
Temporal Dimensions

This chapter addresses the question as to how the Christian devout life is related to contemporary holistic spirituality, taking C. G. Jung as representative of holistic spirituality’s quest to balance the binary elements of the self. By way of contrast, Christian spirituality might seem to require the hierarchical subordination of one part of the self to another, reinforcing suspicions as to its essentially heteronomous nature. Nevertheless, the devout life can be shown to be a life involving the coordination of ‘body, mind, and spirit’. Where contemporary holism emphasizes the spatial balancing of the self the devout life integrates spatial and temporal dimensions of selfhood seeking to be focused on the sacrament of the present moment as it moves forward in tranquillity and equanimity.

scholarly journals EZH2 reduction is an essential mechanoresponse for the maintenance of super-enhancer polarization against compressive stress in human periodontal ligament stem cells

2020 ◽  
Vol 11 (9) ◽  
Author(s):  
Qian Li ◽  
Xiwen Sun ◽  
Yunyi Tang ◽  
Yanan Qu ◽  
Yanheng Zhou ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mechanical Stress ◽  
Periodontal Ligament ◽  
Compressive Force ◽  
Mechanical Stimuli ◽  
Periodontal Ligament Stem Cells ◽  
Super Enhancer ◽  
Ezh2 Expression ◽  
A Genome ◽  
Temporal Dimensions

Abstract Despite the ubiquitous mechanical cues at both spatial and temporal dimensions, cell identities and functions are largely immune to the everchanging mechanical stimuli. To understand the molecular basis of this epigenetic stability, we interrogated compressive force-elicited transcriptomic changes in mesenchymal stem cells purified from human periodontal ligament (PDLSCs), and identified H3K27me3 and E2F signatures populated within upregulated and weakly downregulated genes, respectively. Consistently, expressions of several E2F family transcription factors and EZH2, as core methyltransferase for H3K27me3, decreased in response to mechanical stress, which were attributed to force-induced redistribution of RB from nucleoplasm to lamina. Importantly, although epigenomic analysis on H3K27me3 landscape only demonstrated correlating changes at one group of mechanoresponsive genes, we observed a genome-wide destabilization of super-enhancers along with aberrant EZH2 retention. These super-enhancers were tightly bounded by H3K27me3 domain on one side and exhibited attenuating H3K27ac deposition and flattening H3K27ac peaks along with compensated EZH2 expression after force exposure, analogous to increased H3K27ac entropy or decreased H3K27ac polarization. Interference of force-induced EZH2 reduction could drive actin filaments dependent spatial overlap between EZH2 and super-enhancers and functionally compromise the multipotency of PDLSC following mechanical stress. These findings together unveil a specific contribution of EZH2 reduction for the maintenance of super-enhancer stability and cell identity in mechanoresponse.

Spatiotemporal Object Database Approach to Dynamic Segmentation

2003 ◽  
Vol 1836 (1) ◽  
pp. 118-125 ◽  
Author(s):  
Bo Huang ◽  
Li Yao
Keyword(s):  
Query Language ◽  
Time Varying ◽  
Data Types ◽  
The Road ◽  
Dynamic Segmentation ◽  
Management Group ◽  
Object Database ◽  
On The Road ◽  
Temporal Dimensions ◽  
Spatiotemporal Queries

Dynamic segmentation is viewed as one of the most important functions of geographic information systems for transportation applications. Although the road network and associated events (e.g., pavement material, traffic volume, incidents) can be referenced to both space and time, the spatial and temporal dimensions have not been well integrated. Modeling space-varying, time-varying, and space-time-varying events in dynamic segmentation by using an object database approach that is in line with the Object Database Management Group standard is explored. A mechanism called parametric polymorphism is used to lift conventional data types to spatial, temporal, and spatiotemporal types for maintaining knowledge about events that could change spatially, temporally, and spatiotemporally along linear features. An associated object query language, DS-OQL, was designed to support the formulation of spatial, temporal, and spatiotemporal queries on the road and event information.

scholarly journals Psychophysiology of duration estimation in experienced mindfulness meditators and matched controls

2015 ◽  
Vol 6 ◽  
Author(s):  
Simone Otten ◽  
Eva Schötz ◽  
Marc Wittmann ◽  
Niko Kohls ◽  
Stefan Schmidt ◽  
...  
Keyword(s):  
Duration Estimation

Are the dynamic response characteristics of brachial artery flow-mediated dilation sensitive to the magnitude of increase in shear stimulus?

2008 ◽  
Vol 105 (1) ◽  
pp. 282-292 ◽  
Author(s):  
K. E. Pyke ◽  
J. A. Hartnett ◽  
M. E. Tschakovsky
Keyword(s):  
Shear Stress ◽  
Shear Rate ◽  
Dynamic Response ◽  
Phase I ◽  
Brachial Artery ◽  
Flow Mediated Dilation ◽  
Final Phase ◽  
Stimulus Magnitude ◽  
Brachial Artery Diameter ◽  
Response Characteristics

The purpose of this study was to determine the dynamic characteristics of brachial artery dilation in response to step increases in shear stress [flow-mediated dilation (FMD)]. Brachial artery diameter (BAD) and mean blood velocity (MBV) (Doppler ultrasound) were obtained in 15 healthy subjects. Step increases in MBV at two shear stimulus magnitudes were investigated: large (L; maximal MBV attainable), and small (S; MBV at 50% of the large step). Increase in shear rate (estimate of shear stress: MBV/BAD) was 76.8 ± 15.6 s−1 for L and 41.4 ± 8.7 s−1 for S. The peak %FMD was 14.5 ± 3.8% for L and 5.7 ± 2.1% for S ( P < 0.001). Both the L (all subjects) and the S step trials (12 of 15 subjects) elicited a biphasic diameter response with a fast initial phase (phase I) followed by a slower final phase. Relative contribution of phase I to total FMD when two phases occurred was not sensitive to shear rate magnitude ( r2 = 0.003, slope P = 0.775). Parameters quantifying the dynamics of the FMD response [time delay (TD), time constant (τ)] were also not sensitive to shear rate magnitude for both phases (phase I: TD r2 = 0.03, slope P = 0.376, τ r2 = 0.04, slope P = 0.261; final phase: TD r2 = 0.07, slope P = 0.169, τ r2 = 0.07, slope P = 0.996). These data support the existence of two distinct mechanisms, or sets of mechanisms, in the human conduit artery FMD response that are proportionally sensitive to shear stimulus magnitude and whose dynamic response is not sensitive to shear stimulus magnitude.

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