scholarly journals Free-choice saccades and their underlying determinants: Explorations of high-level voluntary oculomotor control

2019 ◽  
Vol 19 (3) ◽  
pp. 14 ◽  
Author(s):  
Lynn Huestegge ◽  
Oliver Herbort ◽  
Nora Gosch ◽  
Wilfried Kunde ◽  
Aleks Pieczykolan
Keyword(s):  
Free Choice ◽  
Oculomotor Control ◽  
High Level

High-level aspects of oculomotor control during viewing of natural-task images

2003 ◽  
Author(s):  
Roxanne L. Canosa ◽  
Jeff B. Pelz ◽  
Neil R. Mennie ◽  
Joseph Peak
Keyword(s):  
Oculomotor Control ◽  
High Level

scholarly journals Employment, Unemployment And Poverty Reduction

2021 ◽  
Vol 03 (04) ◽  
pp. 84-89
Author(s):  
Guzal Abdukhakimovna Alimova ◽  
Keyword(s):  
Poverty Reduction ◽  
Free Choice ◽  
Macroeconomic Policy ◽  
Social Production ◽  
High Level

Employment of the population is one of the key government tasks. Achieving a high level of employment is one of the main goals of macroeconomic policy in any country, and primarily in such as Uzbekistan. The ideology of universal employment of the entire able-bodied population, supported by the obligation of a person to participate in social production, is being replaced by the concept of ensuring the desired employment and free choice of the form and type of employment.

scholarly journals Inhibiting saccades to hands: High-level visual processes modulate oculomotor control

2021 ◽  
Vol 21 (9) ◽  
pp. 2246
Author(s):  
Hsinyuan Chen ◽  
Martin Schürmann ◽  
David Keeble
Keyword(s):  
Oculomotor Control ◽  
Visual Processes ◽  
High Level

Dynamic Incentive Mechanism for Delivery Slot Management in E-Commerce Attended Home Delivery

2020 ◽  
Vol 54 (3) ◽  
pp. 567-587 ◽  
Author(s):  
Albert Vinsensius ◽  
Yuan Wang ◽  
Ek Peng Chew ◽  
Loo Hay Lee
Keyword(s):  
Free Choice ◽  
Time Slot ◽  
Incentive Mechanism ◽  
Time Windows ◽  
Home Delivery ◽  
Programming Approach ◽  
Dynamic Programming Approach ◽  
Dynamic Time ◽  
High Level ◽  
Selection Of

In attended home delivery, challenges arise in practice because of the short strict time windows, stochastic customer requests, and varying customers’ preferences for delivery slots. In this study, we focus on integrating dynamic time slot incentives and order delivery with the intention of reducing overall delivery cost and improving profitability. The proposed incentive mechanism is able to exploit the variability in the marginal fulfillment cost of an order and the customers’ preferences to influence the customers’ selection of delivery slots. We present an approximate dynamic programming approach to estimate the marginal fulfillment cost using the operational vehicle routing cost while accounting for future orders. We demonstrate that the proposed incentive mechanism can achieve a high level of savings (of up to 70%) with respect to the benchmark customer-free-choice scenario. It is also noted that the proposed mechanism effectively exploits higher order density and vehicle availability to achieve a higher level of savings.

scholarly journals Oculomotor control in children with Special Educational Needs (SEN): the development and piloting of a novel app-based therapeutic intervention

2021 ◽  
Author(s):  
Rosie Clark ◽  
Cathy Williams ◽  
Iain D. Gilchrist
Keyword(s):  
Eye Movement ◽  
Movement Control ◽  
Educational Needs ◽  
Oculomotor Control ◽  
Special Educational Needs ◽  
Eye Movement Control ◽  
Movement Training ◽  
Wide Range ◽  
Full Study ◽  
High Level

AbstractChildren with Special Educational Needs (SEN) often have impaired eye movement control which can impact on a wide range of everyday activities including in the classroom, socialising, participation in sport or crossing a road. Although some health practitioners offer eye movement therapies these tend not to have been systematically developed or evaluated. We have developed a new app to deliver eye movement training, based on detailed scientific understanding of eye movement control and extensive clinical experience with this patient group. We first investigated the acceptability of the app within several schools and made modifications based on detailed feedback from the children. Next, we conducted a pilot study to test the feasibility of using the app with 12 children (5–17 years old) who had SEN. The children successfully undertook app-based training for 10 min per day for 4–5 weeks. There was a high level of attendance and no attrition. We found some variation across participants in their ability to play on the app and the level of engagement. This indicates that pre-assessing children for ability and engagement may be important. This encouraging proof of concept study justifies the development of a full study. Given the time and money spent on existing commercially-offered or internet-based non-validated therapies, this would have substantial patient benefit regardless of the outcome: evidence of no effect could reassure parents that this kind of treatment was not needed, whilst evidence of effect suggests this as a useful treatment for children with poor oculomotor control.

Transcription factor/DNA interactions visualized by electron spectroscopic imaging

1992 ◽  
Vol 50 (1) ◽  
pp. 450-451
Author(s):  
David P. Bazett-Jones ◽  
Mark L. Brown
Keyword(s):  
Transcription Factor ◽  
Dna Sequences ◽  
Transcription Initiation ◽  
Molecular Mechanisms ◽  
Phosphorus Content ◽  
Spectroscopic Imaging ◽  
Electron Spectroscopic Imaging ◽  
Dna Backbone ◽  
Two Parameters ◽  
High Level

A multisubunit RNA polymerase enzyme is ultimately responsible for transcription initiation and elongation of RNA, but recognition of the proper start site by the enzyme is regulated by general, temporal and gene-specific trans-factors interacting at promoter and enhancer DNA sequences. To understand the molecular mechanisms which precisely regulate the transcription initiation event, it is crucial to elucidate the structure of the transcription factor/DNA complexes involved. Electron spectroscopic imaging (ESI) provides the opportunity to visualize individual DNA molecules. Enhancement of DNA contrast with ESI is accomplished by imaging with electrons that have interacted with inner shell electrons of phosphorus in the DNA backbone. Phosphorus detection at this intermediately high level of resolution (≈lnm) permits selective imaging of the DNA, to determine whether the protein factors compact, bend or wrap the DNA. Simultaneously, mass analysis and phosphorus content can be measured quantitatively, using adjacent DNA or tobacco mosaic virus (TMV) as mass and phosphorus standards. These two parameters provide stoichiometric information relating the ratios of protein:DNA content.

Advances in Stem Instrumentation for Biology

1990 ◽  
Vol 48 (1) ◽  
pp. 362-363
Author(s):  
J. S. Wall
Keyword(s):  
Scanning Transmission Electron Microscope ◽  
Carbon Films ◽  
Specimen Preparation ◽  
Material Deposition ◽  
Active User ◽  
Percent Improvement ◽  
Scanning Transmission ◽  
The Moment ◽  
Film Substrate ◽  
High Level

The forte of the Scanning transmission Electron Microscope (STEM) is high resolution imaging with high contrast on thin specimens, as demonstrated by visualization of single heavy atoms. of equal importance for biology is the efficient utilization of all available signals, permitting low dose imaging of unstained single molecules such as DNA.Our work at Brookhaven has concentrated on: 1) design and construction of instruments optimized for a narrow range of biological applications and 2) use of such instruments in a very active user/collaborator program. Therefore our program is highly interactive with a strong emphasis on producing results which are interpretable with a high level of confidence.The major challenge we face at the moment is specimen preparation. The resolution of the STEM is better than 2.5 A, but measurements of resolution vs. dose level off at a resolution of 20 A at a dose of 10 el/A2 on a well-behaved biological specimen such as TMV (tobacco mosaic virus). To track down this problem we are examining all aspects of specimen preparation: purification of biological material, deposition on the thin film substrate, washing, fast freezing and freeze drying. As we attempt to improve our equipment/technique, we use image analysis of TMV internal controls included in all STEM samples as a monitor sensitive enough to detect even a few percent improvement. For delicate specimens, carbon films can be very harsh-leading to disruption of the sample. Therefore we are developing conducting polymer films as alternative substrates, as described elsewhere in these Proceedings. For specimen preparation studies, we have identified (from our user/collaborator program ) a variety of “canary” specimens, each uniquely sensitive to one particular aspect of sample preparation, so we can attempt to separate the variables involved.

A Questionnaire Survey of Current Rehabilitation Practices for Adults With Normal Hearing Sensitivity Who Experience Auditory Difficulties

2020 ◽  
Vol 29 (4) ◽  
pp. 738-761
Author(s):  
Tess K. Koerner ◽  
Melissa A. Papesh ◽  
Frederick J. Gallun
Keyword(s):  
Hearing Aids ◽  
Questionnaire Survey ◽  
Patient Population ◽  
Clinical Care ◽  
Normal Hearing ◽  
Auditory Training ◽  
Training Methods ◽  
Hearing Sensitivity ◽  
Considerable Benefit ◽  
High Level

Purpose A questionnaire survey was conducted to collect information from clinical audiologists about rehabilitation options for adult patients who report significant auditory difficulties despite having normal or near-normal hearing sensitivity. This work aimed to provide more information about what audiologists are currently doing in the clinic to manage auditory difficulties in this patient population and their views on the efficacy of recommended rehabilitation methods. Method A questionnaire survey containing multiple-choice and open-ended questions was developed and disseminated online. Invitations to participate were delivered via e-mail listservs and through business cards provided at annual audiology conferences. All responses were anonymous at the time of data collection. Results Responses were collected from 209 participants. The majority of participants reported seeing at least one normal-hearing patient per month who reported significant communication difficulties. However, few respondents indicated that their location had specific protocols for the treatment of these patients. Counseling was reported as the most frequent rehabilitation method, but results revealed that audiologists across various work settings are also successfully starting to fit patients with mild-gain hearing aids. Responses indicated that patient compliance with computer-based auditory training methods was regarded as low, with patients generally preferring device-based rehabilitation options. Conclusions Results from this questionnaire survey strongly suggest that audiologists frequently see normal-hearing patients who report auditory difficulties, but that few clinicians are equipped with established protocols for diagnosis and management. While many feel that mild-gain hearing aids provide considerable benefit for these patients, very little research has been conducted to date to support the use of hearing aids or other rehabilitation options for this unique patient population. This study reveals the critical need for additional research to establish evidence-based practice guidelines that will empower clinicians to provide a high level of clinical care and effective rehabilitation strategies to these patients.

805: High-Level Cyclin D1 is Associated with High Gleason Grade and Predicts Worse Biochemical-Free Survival in Prostate Cancer

2006 ◽  
Vol 175 (4S) ◽  
pp. 260-260
Author(s):  
Rile Li ◽  
Hong Dai ◽  
Thomas M. Wheeler ◽  
Anna Frolov ◽  
Gustavo Ayala
Keyword(s):  
Prostate Cancer ◽  
Cyclin D1 ◽  
Gleason Grade ◽  
Free Survival ◽  
High Level
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