scholarly journals Characterizing lamina cribrosa and optic nerve head geometry in normal human eyes

2013 ◽  
Vol 13 (15) ◽  
pp. P35-P35
Author(s):  
A. S. Bhakta ◽  
D. J. Marrelli ◽  
N. Sredar ◽  
K. M. Ivers ◽  
H. M. Queener ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Lamina Cribrosa ◽  
Normal Human ◽  
Human Eyes

scholarly journals Bruch’s membrane opening enlargement and its implication on the myopic optic nerve head

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Mi Sun Sung ◽  
Min Young Heo ◽  
Hwan Heo ◽  
Sang Woo Park
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Lamina Cribrosa ◽  
Cross Sectional Study ◽  
Multivariate Regression Model ◽  
Bruch's Membrane ◽  
Bruch’S Membrane ◽  
Cross Sectional ◽  
Bruch’S Membrane Opening ◽  
Parapapillary Atrophy

AbstractWe examined the association between Bruch’s membrane opening (BMO) area and various ocular parameters and investigated the implication of BMO enlargement on the myopic optic nerve head. One hundred eighty-five myopic eyes were included in this cross-sectional study. Among the included eyes, 53 having axial lengths between 26 and 27 mm were further analyzed to investigate the association between BMO area and various ocular parameters. BMO area, BMO-minimum rim width (BMO-MRW), peripapillary choroidal thickness (pCT), width of β-parapapillary atrophy with and without Bruch’s membrane (PPA+BM and PPA−BM), and presence of lamina cribrosa (LC) defect were evaluated. We found that BMO area tended to increase with increasing axial length, but varied among the highly myopic eyes even though they had similar degrees of myopia. In the subgroup analysis of eyes with axial lengths between 26 and 27 mm, BMO area was highly variable and it significantly correlated with PPA−BM width and temporal-inferior, nasal-inferior, and nasal BMO-MRW and pCT. LC defects were more common in myopic eyes with enlarged BMO. A multivariate regression model revealed that higher intraocular pressure, enlarged BMO, and thinner BMO-MRW were associated with LC defects in highly myopic eyes. These findings should be considered when evaluating myopic eyes.

scholarly journals Longitudinal assessment of optic nerve head changes using optical coherence tomography in a primate microbead model of ocular hypertension

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Anita S. Y. Chan ◽  
Tin Aung Tun ◽  
John C. Allen ◽  
Myoe Naing Lynn ◽  
Sai Bo Bo Tun ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Nerve ◽  
Ocular Hypertension ◽  
Optic Nerve Head ◽  
Structural Damage ◽  
Structural Changes ◽  
Lamina Cribrosa ◽  
Optical Coherence ◽  
Longitudinal Assessment ◽  
The Mean

Abstract In humans, the longitudinal characterisation of early optic nerve head (ONH) damage in ocular hypertension (OHT) is difficult as patients with glaucoma usually have structural ONH damage at the time of diagnosis. Previous studies assessed glaucomatous ONH cupping by measuring the anterior lamina cribrosa depth (LCD) and minimal rim width (MRW) using optical coherence tomography (OCT). In this study, we induced OHT by repeated intracameral microbead injections in 16 cynomolgus primates (10 unilateral; 6 bilateral) and assessed the structural changes of the ONH longitudinally to observe early changes. Elevated intraocular pressure (IOP) in OHT eyes was maintained for 7 months and serial OCT measurements were performed during this period. The mean IOP was significantly elevated in OHT eyes when compared to baseline and compared to the control eyes. Thinner MRW and deeper LCD values from baseline were observed in OHT eyes with the greatest changes seen between month 1 and month 2 of OHT. Both the mean and maximum IOP values were significant predictors of MRW and LCD changes, although the maximum IOP was a slightly better predictor. We believe that this model could be useful to study IOP-induced early ONH structural damage which is important for understanding glaucoma pathogenesis.

Effect of Aging on Nocturnal Blood Flow in the Optic Nerve Head and Macula in Healthy Human Eyes

2008 ◽  
Vol 17 (5) ◽  
pp. 366-371 ◽  
Author(s):  
Teruyo Kida ◽  
John H.K. Liu ◽  
Robert N. Weinreb
Keyword(s):  
Blood Flow ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Healthy Human ◽  
Human Eyes

Elevated Levels of RhoA in the Optic Nerve Head of Human Eyes With Glaucoma

2012 ◽  
Vol 21 (8) ◽  
pp. 530-538 ◽  
Author(s):  
Brian Goldhagen ◽  
Alan D. Proia ◽  
David L. Epstein ◽  
Ponugoti Vasantha Rao
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Human Eyes

scholarly journals A poroelastic model for the perfusion of the lamina cribrosa in the optic nerve head

2014 ◽  
Vol 257 ◽  
pp. 33-41 ◽  
Author(s):  
Paola Causin ◽  
Giovanna Guidoboni ◽  
Alon Harris ◽  
Daniele Prada ◽  
Riccardo Sacco ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Lamina Cribrosa ◽  
Poroelastic Model

scholarly journals 3-D Histomorphometry of the Normal and Early Glaucomatous Monkey Optic Nerve Head: Lamina Cribrosa and Peripapillary Scleral Position and Thickness

2007 ◽  
Vol 48 (10) ◽  
pp. 4597 ◽  
Author(s):  
Hongli Yang ◽  
J. Crawford Downs ◽  
Christopher Girkin ◽  
Lisandro Sakata ◽  
Anthony Bellezza ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Lamina Cribrosa

scholarly journals In Vivo Changes in Lamina Cribrosa Microarchitecture and Optic Nerve Head Structure in Early Experimental Glaucoma

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0134223 ◽  
Author(s):  
Kevin M. Ivers ◽  
Nripun Sredar ◽  
Nimesh B. Patel ◽  
Lakshmi Rajagopalan ◽  
Hope M. Queener ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Lamina Cribrosa ◽  
Experimental Glaucoma
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