scholarly journals Perceptual learning and changes in white matter in the aged brain revealed by diffusion-tensor imaging (DTI)

2010 ◽  
Vol 10 (7) ◽  
pp. 912-912 ◽  
Author(s):  
Y. Yotsumoto ◽  
L.-H. Chang ◽  
R. Ni ◽  
D. Salat ◽  
G. Andersen ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Perceptual Learning ◽  
Diffusion Tensor ◽  
Aged Brain ◽  
Diffusion Tensor Imaging Dti

Diffusion tensor imaging in multiple sclerosis: a tool for monitoring changes in normal-appearing white matter

2004 ◽  
Vol 10 (2) ◽  
pp. 188-196 ◽  
Author(s):  
Emmanuelle Cassol ◽  
Jean-Philippe Ranjeva ◽  
Danielle Ibarrola ◽  
Claude Mékies ◽  
Claude Manelfe ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Lesion Load ◽  
Normal Appearing White Matter ◽  
Relapsing Remitting ◽  
One Year ◽  
Diffusion Tensor Imaging Dti

Our objectives were to determine the reproducibility of diffusion tensor imaging (DTI) in volunteers and to evaluate the ability of the method to monitor longitudinal changes occurring in the normal-appearing white matter (NAWM) of patients with multiple sclerosis (MS). DTI was performed three-mo nthly for one year in seven MS patients: three relapsing-remitting (RRMS), three secondary progressive (SPMS) and one relapsing SP. They were selected with a limited cerebral lesion load. Seven age- and sex-matched controls also underwent monthly examinations for three months. Diffusivity and anisotropy were quantified over the segmented whole supratentorial white matter, with the indices of trace (Tr) and fractional anisotropy (FA). Results obtained in volunteers show the reproducibility of the method. Patients had higher trace and lower anisotropy than matched controls (P B-0.0001). O ver the follow-up, both Tr and FA indicated a recovery after the acute phase in RRMS and a progressive shift towards abnormal values in SPMS. A lthough this result is not statistically significant, it suggests that DTI is sensitive to microscopic changes occurring in tissue of normal appearance in conventional images and could be useful for monitoring the course of the disease, even though it was unable to clearly distinguish between the various physiopathological processes involved.

scholarly journals Magnetic resonance diffusion tensor imaging in psychiatry: a narrative review of its potential role in diagnosis

2020 ◽  
Author(s):  
Piotr Podwalski ◽  
Krzysztof Szczygieł ◽  
Ernest Tyburski ◽  
Leszek Sagan ◽  
Błażej Misiak ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
Potential Role ◽  
Diffusion Tensor ◽  
Mean Diffusivity ◽  
Water Molecules ◽  
Mental Diseases ◽  
The Brain ◽  
Diffusion Tensor Imaging Dti

Abstract Diffusion tensor imaging (DTI) is an imaging technique that uses magnetic resonance. It measures the diffusion of water molecules in tissues, which can occur either without restriction (i.e., in an isotropic manner) or limited by some obstacles, such as cell membranes (i.e., in an anisotropic manner). Diffusion is most often measured in terms of, inter alia, fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD). DTI allows us to reconstruct, visualize, and evaluate certain qualities of white matter. To date, many studies have sought to associate various changes in the distribution of diffusion within the brain with mental diseases and disorders. A better understanding of white matter integrity disorders can help us recognize the causes of diseases, as well as help create objective methods of psychiatric diagnosis, identify biomarkers of mental illness, and improve pharmacotherapy. The aim of this work is to present the characteristics of DTI as well as current research on its use in schizophrenia, affective disorders, and other mental disorders.

TU-CD-BRB-05: Radiation Damage Signature of White Matter Fiber Bundles Using Diffusion Tensor Imaging (DTI)

2015 ◽  
Vol 42 (6Part32) ◽  
pp. 3603-3603
Author(s):  
T Zhu ◽  
C Chapman ◽  
C Tsien ◽  
T Lawrence ◽  
Y Cao
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Radiation Damage ◽  
Diffusion Tensor ◽  
Fiber Bundles ◽  
Diffusion Tensor Imaging Dti

Assessment of white matter abnormalities in paranoid schizophrenia and bipolar mania patients from Chengdu, China

2011 ◽  
Vol 26 (S2) ◽  
pp. 940-940
Author(s):  
L. Cui ◽  
Z. Chen ◽  
W. Deng ◽  
X. Huang ◽  
M. Li ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Paranoid Schizophrenia ◽  
Health Centre ◽  
White Matter Abnormalities ◽  
Diagnostic And Statistical Manual ◽  
Bipolar Mania ◽  
Shared Risk ◽  
Diffusion Tensor Imaging Dti

IntroductionWhite matter abnormalities have been repeatedly reported in both schizophrenia and bipolar disorder (BD) diseases from diffusion tensor imaging (DTI) studies respectively, while the empirical evidences about the diagnostic specificity of white matter abnormalities in these disorders are still limited.Objectives25 patients with paranoid schizophrenia and 18 patients with bipolar mania were recruited from the in-patient unit of the Mental Health Centre, West China Hospital, China.Patients were diagnosed according to the criteria of Diagnostic and Statistical Manual of Mental Disorders-Version IV (DSM- IV). 30 healthy controls were recruited from the community by means of leaflets distributed throughout Chengdu city.AimsThis study sought to investigate the alterations in fractional anisotropy (FA) in white matter throughout the entire brain of patients from Chengdu, China with paranoid schizophrenia and bipolar mania.MethodsDiffusion tensor imaging (DTI) was used to assess white matter integrity in patients with paranoid schizophrenia and bipolar mania, as well as in normal controls. The differences in FA were measured by use of voxel-based analysis.ResultsReduced FA was found in the left posterior corona radiate (PCR) in patients with bipolar mania and paranoid schizophrenia compared to the controls. Patients with bipolar mania also showed a significant reduction in FA in right posterior corona radiate and in right anterior thalamic radiation (ATR).ConclusionsCommon abnormalities in the left PCR might imply an overlap in white matter pathology of both diseases and might be related to the shared risk factors for both disorders.

Diffusion tensor imaging in schizophrenia

2008 ◽  
Vol 23 (4) ◽  
pp. 255-273 ◽  
Author(s):  
Marinos Kyriakopoulos ◽  
Theodoros Bargiotas ◽  
Gareth J. Barker ◽  
Sophia Frangou
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Brain Regions ◽  
Basic Principles ◽  
Future Directions ◽  
White Matter Abnormalities ◽  
Non Invasive ◽  
Brain White Matter ◽  
Diffusion Tensor Imaging Dti

AbstractDiffusion tensor imaging (DTI) is a magnetic resonance imaging technique that is increasingly being used for the non-invasive evaluation of brain white matter abnormalities. In this review, we discuss the basic principles of DTI, its roots and the contribution of European centres in its development, and we review the findings from DTI studies in schizophrenia. We searched EMBASE, PubMed, PsychInfo, and Medline from February 1998 to December 2006 using as keywords ‘schizophrenia’, ‘diffusion’, ‘tensor’, and ‘DTI’. Forty studies fulfilling the inclusion criteria of this review were included and systematically reviewed. White matter abnormalities in many diverse brain regions were identified in schizophrenia. Although the findings are not completely consistent, frontal and temporal white matter seems to be more commonly affected. Limitations and future directions of this method are discussed.

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