Confocal Raman Spectroscopy as an Optical Sensor to Detect Advanced Glycation End Products of the Skin Dermis

2015 ◽  
Vol 13 (9) ◽  
pp. 791-801 ◽  
Author(s):  
L. Pereira ◽  
C. A. Téllez Soto ◽  
L. Dos Santos ◽  
P. P. Favero ◽  
A. A. Martin
Keyword(s):  
Raman Spectroscopy ◽  
Advanced Glycation End Products ◽  
Optical Sensor ◽  
Advanced Glycation ◽  
Confocal Raman Spectroscopy ◽  
Glycation End Products ◽  
End Products ◽  
Confocal Raman

Raman spectroscopy of advanced glycation end products (AGEs), possible markers for progressive retinal dysfunction

2008 ◽  
Vol 39 (11) ◽  
pp. 1635-1642 ◽  
Author(s):  
Anna M. Pawlak ◽  
J. Renwick Beattie ◽  
Josephine V. Glenn ◽  
Alan W. Stitt ◽  
John J. McGarvey
Keyword(s):  
Raman Spectroscopy ◽  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Retinal Dysfunction ◽  
Glycation End Products ◽  
End Products

scholarly journals An Intra-Oral Optical Sensor for the Real-Time Identification and Assessment of Wine Intake

Sensors ◽  
2019 ◽  
Vol 19 (21) ◽  
pp. 4719 ◽  
Author(s):  
Faragó ◽  
Gălătuș ◽  
Hintea ◽  
Boșca ◽  
Feurdean ◽  
...  
Keyword(s):  
Real Time ◽  
Fiber Optics ◽  
Advanced Glycation End Products ◽  
Optical Sensor ◽  
Wide Spectrum ◽  
Optical Fiber Sensor ◽  
Advanced Glycation ◽  
Blood Concentrations ◽  
Glycation End Products ◽  
End Products

Saliva has gained considerable attention as a diagnostics alternative to blood analyses. A wide spectrum of salivary compounds is correlated to blood concentrations of biomarkers, providing informative and discriminative data regarding the state of health. Intra-oral detection and assessment of food and beverage intake can be correlated and provides valuable information to forecast the formation and modification of salivary biomarkers. In this context, the present work proposes a novel intra-oral optical fiber sensor, developed around an optical coupler topology, and exemplified on the detection and assessment of wine intake, which is accounted for example for the formation of Nε-carboxymethyllysine Advanced Glycation End-products. A laboratory proof of concept validates the proposed solution on four white and four red wine samples. The novel optical sensor geometry shows good spectral properties, accounting for selectivity with respect to grape-based soft drinks. This enables intra-oral detection and objective quality assessment of wine. Moreover, its implementation exploits the advantages of fiber-optics sensing and facilitates integration into a mouthguard, holding considerable potential for real-time biomedical applications to investigate Advanced Glycation End-products in the saliva and their connection with consumption of wine, for the evaluation of risk factors in diet-related diseases.

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