A Probe-Based qPCR Assay for Quantification and Classification of Hepatitis E Virus

2017 ◽  
Vol 9 (12) ◽  
pp. 2119-2125 ◽  
Author(s):  
Dong Yang ◽  
Zhigang Qiu ◽  
Weihong Cui ◽  
Zhiqiang Shen ◽  
Weili Liu ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Qpcr Assay

scholarly journals Classification of human and zoonotic group hepatitis E virus (HEV) using antigen detection

2017 ◽  
Vol 101 (23-24) ◽  
pp. 8585-8594 ◽  
Author(s):  
Gui-Ping Wen ◽  
Zi-Min Tang ◽  
Si-Ling Wang ◽  
Wen-Fang Ji ◽  
Wei Cai ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Antigen Detection

scholarly journals Classification of the Zoonotic Hepatitis E Virus Genotype 3 Into Distinct Subgenotypes

2021 ◽  
Vol 11 ◽  
Author(s):  
Florence Nicot ◽  
Chloé Dimeglio ◽  
Marion Migueres ◽  
Nicolas Jeanne ◽  
Justine Latour ◽  
...  
Keyword(s):  
Molecular Epidemiology ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Genotype 3 ◽  
Genome Sequences ◽  
Virus Genotype ◽  
Subtype Classification ◽  
Reference Sequences ◽  
Epidemiology Studies

Hepatitis E virus (HEV) genotype 3 is the most common genotype linked to HEV infections in Europe and America. Three major clades (HEV-3.1, HEV-3.2, and HEV-3.3) have been identified but the overlaps between intra-subtype and inter-subtype p-distances make subtype classification inconsistent. Reference sequences have been proposed to facilitate communication between researchers and new putative subtypes have been identified recently. We have used the full or near full-length HEV-3 genome sequences available in the Genbank database (April 2020; n = 503) and distance analyses of clades HEV-3.1 and HEV-3.2 to determine a p-distance cut-off (0.093 nt substitutions/site) in order to define subtypes. This could help to harmonize HEV-3 genotyping, facilitate molecular epidemiology studies and investigations of the biological and clinical differences between HEV-3 subtypes.

scholarly journals Genetic Variability and the Classification of Hepatitis E Virus

2013 ◽  
Vol 87 (8) ◽  
pp. 4161-4169 ◽  
Author(s):  
D. B. Smith ◽  
M. A. Purdy ◽  
P. Simmonds
Keyword(s):  
Genetic Variability ◽  
Hepatitis E Virus ◽  
Hepatitis E

scholarly journals Classification of hepatitis E virus diffusion patterns inferred by genome analysis: observation of 13 hepatitis E cases in Gifu, Japan

Kanzo ◽  
2022 ◽  
Vol 63 (1) ◽  
pp. 35-38
Author(s):  
Tatsunori Nakano ◽  
Yoichi Nishigaki ◽  
Hideki Hayashi ◽  
Satoko Tajirika ◽  
Taisei Iwasa ◽  
...  
Keyword(s):  
Genome Analysis ◽  
Hepatitis E Virus ◽  
Hepatitis E

scholarly journals Genetic Variability and the Classification of Hepatitis E Virus

2013 ◽  
Vol 87 (13) ◽  
pp. 7787-7787
Author(s):  
D. B. Smith ◽  
M. A. Purdy ◽  
P. Simmonds
Keyword(s):  
Genetic Variability ◽  
Hepatitis E Virus ◽  
Hepatitis E

scholarly journals Characterization of a Novel Rat Hepatitis E Virus Isolated from an Asian Musk Shrew (Suncus murinus)

Viruses ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 715
Author(s):  
Huimin Bai ◽  
Wei Li ◽  
Dawei Guan ◽  
Juan Su ◽  
Changwen Ke ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Open Reading Frames ◽  
Entire Genome ◽  
Musk Shrew ◽  
Recovered Virus ◽  
Reading Frames ◽  
New Reservoir

The Asian musk shrew (shrew) is a new reservoir of a rat hepatitis E virus (HEV) that has been classified into genotype HEV-C1 in the species Orthohepevirus C. However, there is no information regarding classification of the new rat HEV based on the entire genome sequences, and it remains unclear whether rat HEV transmits from shrews to humans. We herein inoculated nude rats (Long-Evans rnu/rnu) with a serum sample from a shrew trapped in China, which was positive for rat HEV RNA, to isolate and characterize the rat HEV distributed in shrews. A rat HEV strain, S1129, was recovered from feces of the infected nude rat, indicating that rat HEV was capable of replicating in rats. S1129 adapted and grew well in PLC/PRF/5 cells, and the recovered virus (S1129c1) infected Wistar rats. The entire genomes of S1129 and S1129c1 contain four open reading frames and share 78.3–81.8% of the nucleotide sequence identities with known rat HEV isolates, demonstrating that rat HEVs are genetically diverse. We proposed that genotype HEV-C1 be further classified into subtypes HEV-C1a to HEV-C1d and that the S1129 strain circulating in the shrew belonged to the new subtype HEV-C1d. Further studies should focus on whether the S1129 strain infects humans.

Hepatitis E Virus in LeberBiopsien von Patienten mit akuter Hepatitis unbekannter Ätiologie

2011 ◽  
Vol 49 (01) ◽  
Author(s):  
C Dorloff ◽  
J Hemberger ◽  
M Odenthal ◽  
H Holzmann ◽  
S Aberle ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E

Severe course of Hepatitis E Virus infection in a patient with pre-existing autoimmune liver disease

2013 ◽  
Vol 51 (01) ◽  
Author(s):  
S Schlosser ◽  
J Pflaum ◽  
K Weigand ◽  
JJ Wenzel ◽  
W Jilg ◽  
...  
Keyword(s):  
Liver Disease ◽  
Virus Infection ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Autoimmune Liver Disease

Transfusion-transmitted hepatitis E virus infections: a risk for immunosuppressed patients

2018 ◽  
Vol 56 (01) ◽  
pp. E2-E89
Author(s):  
D Westhölter ◽  
J Hartl ◽  
J Hiller ◽  
U Denzer ◽  
S Peine ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Virus Infections ◽  
Immunosuppressed Patients
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