Calcium Phosphate Silicate and Calcium Silicate Cements Suppressing Osteoclasts Activity Through Cytokine Regulation

2018 ◽  
Vol 18 (10) ◽  
pp. 6799-6804 ◽  
Author(s):  
Wei Yuan ◽  
Xin He ◽  
Jingshu Zhang ◽  
Yadong Chen ◽  
Tianxing Gong ◽  
...  
2012 ◽  
Vol 91 (12) ◽  
pp. 1166-1171 ◽  
Author(s):  
X.V. Tran ◽  
C. Gorin ◽  
C. Willig ◽  
B. Baroukh ◽  
B. Pellat ◽  
...  

In cases of pulp injury, capping materials are used to enhance tertiary dentin formation; Ca(OH)2 and MTA are the current gold standards. The aim of this study was to evaluate the capacity of a new calcium-silicate-based restorative cement to induce pulp healing in a rat pulp injury model. For that purpose, cavities with mechanical pulp exposure were prepared on maxillary first molars of 27 six-week-old male rats, and damaged pulps were capped with either the new calcium-silicate-based restorative cement (Biodentine), MTA, or Ca(OH)2. Cavities were sealed with glass-ionomer cement, and the repair process was assessed at several time-points. At day 7, our results showed that both the evaluated cement and MTA induced cell proliferation and formation of mineralization foci, which were strongly positive for osteopontin. At longer time-points, we observed the formation of a homogeneous dentin bridge at the injury site, secreted by cells displaying an odontoblastic phenotype. In contrast, the reparative tissue induced by Ca(OH)2 showed porous organization, suggesting a reparative process different from those induced by calcium silicate cements. Analysis of these data suggests that the evaluated cement can be used for direct pulp-capping.


2015 ◽  
Vol 5 (4) ◽  
pp. 457-466 ◽  
Author(s):  
Tianxing Gong ◽  
Zhiqin Wang ◽  
Yixi Zhang ◽  
Yubiao Zhang ◽  
Mingxiao Hou ◽  
...  

2012 ◽  
Vol 57 (8) ◽  
pp. 1054-1061 ◽  
Author(s):  
M.G. Gandolfi ◽  
F. Iacono ◽  
C. Pirani ◽  
C. Prati

2016 ◽  
Vol 11 (4) ◽  
pp. 045002 ◽  
Author(s):  
Tianxing Gong ◽  
Yadong Chen ◽  
Yixi Zhang ◽  
Yubiao Zhang ◽  
Xinwei Liu ◽  
...  

2012 ◽  
Vol 46 (3) ◽  
pp. 242-252 ◽  
Author(s):  
S. S. Hakki ◽  
B. S. Bozkurt ◽  
B. Ozcopur ◽  
M. G. Gandolfi ◽  
C. Prati ◽  
...  

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