Halloysite Clay Nanotubes for Controlled Release of Protective Agents

2011 ◽  
Vol 11 (11) ◽  
pp. 10007-10026 ◽  
Author(s):  
Elshad Abdullayev ◽  
Yuri Lvov
Keyword(s):  
Controlled Release ◽  
Protective Agents ◽  
Clay Nanotubes

Halloysite Clay Nanotubes for Controlled Release of Protective Agents

ACS Nano ◽  
2008 ◽  
Vol 2 (5) ◽  
pp. 814-820 ◽  
Author(s):  
Yuri M. Lvov ◽  
Dmitry G. Shchukin ◽  
Helmuth Möhwald ◽  
Ronald R. Price
Keyword(s):  
Controlled Release ◽  
Protective Agents ◽  
Clay Nanotubes

Evaluation of Some Protective Agents on Stability and Controlled Release of Oral Pharmaceutical Forms by Fluid Bed Technique

1997 ◽  
Vol 23 (8) ◽  
pp. 817-826 ◽  
Author(s):  
P. Prinderre ◽  
E. Cauture ◽  
Ph. Piccerelle ◽  
G. Kalantzis ◽  
J. Kaloustian ◽  
...  
Keyword(s):  
Controlled Release ◽  
Protective Agents ◽  
Fluid Bed

Organized Shells on Clay Nanotubes for Controlled Release of Macromolecules

2009 ◽  
Vol 30 (2) ◽  
pp. 99-103 ◽  
Author(s):  
Nalinkanth G. Veerabadran ◽  
Dmitriy Mongayt ◽  
Vladimir Torchilin ◽  
Ronald R. Price ◽  
Yuri M. Lvov
Keyword(s):  
Controlled Release ◽  
Clay Nanotubes

Controlled release antibiotics for dry powder lung delivery

2009 ◽  
Vol 00 (00) ◽  
pp. 090805050810080-8 ◽  
Author(s):  
Handoko Adi ◽  
Paul Michael Young ◽  
Hak-Kim Chan ◽  
Rania Salama ◽  
Daniela Traini
Keyword(s):  
Controlled Release ◽  
Dry Powder ◽  
Lung Delivery

Molecular Mechanism of Apoptosis Induction by Resveratrol, a Natural Cancer Chemopreventive Agent

2008 ◽  
Vol 78 (1) ◽  
pp. 3-8 ◽  
Author(s):  
Fan ◽  
Jiang ◽  
Zhang ◽  
Bai
Keyword(s):  
Cancer Treatment ◽  
Molecular Mechanism ◽  
Apoptosis Induction ◽  
Protective Agents ◽  
Chemopreventive Agent ◽  
Naturally Occurring ◽  
Apoptosis Pathways ◽  
Present Understanding

In efforts to identify naturally occurring compounds that act as protective agents, resveratrol, a phytoalexin existing in wine, has attracted much interest because of its diverse pharmacological characteristics. Considering that apoptosis induction is the most potent defense approach for cancer treatment, we have tried to summarize our present understanding of apoptosis induction by resveratrol based on the two major apoptosis pathways.

Controlled Release of Metformin Hydrochloride I. In vitro Release from Physical Mixture Containing Xanthan Gum as Hydrophilic Rate Retarding Polymer

1970 ◽  
Vol 4 (1) ◽  
Author(s):  
Mashkura Ashrafi ◽  
Jakir Ahmed Chowdhury ◽  
Md Selim Reza
Keyword(s):  
Controlled Release ◽  
Xanthan Gum ◽  
In Vitro Release ◽  
Correlation Coefficients ◽  
High Ratio ◽  
Water Soluble ◽  
Metformin Hydrochloride ◽  
Model Drug ◽  
Very High

Capsules of different formulations were prepared by using a hydrophilic polymer, xanthan gum and a filler Ludipress. Metformin hydrochloride, which is an anti-diabetic agent, was used as a model drug here with the aim to formulate sustained release capsules. In the first 6 formulations, metformin hydrochloride and xanthan gum were used in different ratio. Later, Ludipress was added to the formulations in a percentage of 8% to 41%. The total procedure was carried out by physical mixing of the ingredients and filling in capsule shells of size ‘1’. As metformin hydrochloride is a highly water soluble drug, the dissolution test was done in 250 ml distilled water in a thermal shaker (Memmert) with a shaking speed of 50 rpm at 370C &plusmn 0.50C for 6 hours. After the dissolution, the data were treated with different kinetic models. The results found from the graphs and data show that the formulations follow the Higuchian release pattern as they showed correlation coefficients greater than 0.99 and the sustaining effect of the formulations was very high when the xanthan gum was used in a very high ratio with the drug. It was also investigated that the Ludipress extended the sustaining effect of the formulation to some extent. But after a certain period, Ludipress did not show any significant effect as the pores made by the xanthan gum network were already blocked. It is found here that when the metformin hydrochloride and the xanthan gum ratio was 1:1, showed a high percentage of drug release, i.e. 91.80% of drug was released after 6 hours. But With a xanthan gum and metformin hydrochloride ratio of 6:1, a very slow release of the drug was obtained. Only 66.68% of the drug was released after 6 hours. The percent loading in this case was 14%. Again, when Ludipress was used in high ratio, it was found to retard the release rate more prominently. Key words: Metformin Hydrochloride, Xanthan Gum, Controlled release capsule Dhaka Univ. J. Pharm. Sci. Vol.4(1) 2005 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

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