Characterization and Stability of Liposome-Enveloped Trypsin/Fe3O4 for Drug Delivery and Drug Release Behavior

2011 ◽  
Vol 11 (5) ◽  
pp. 4592-4595 ◽  
Author(s):  
Min-Jung Kim ◽  
Dae-Hwan Jang ◽  
Hak-Kyong Kim ◽  
Young-In Lee ◽  
Gun-Jae Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Release Behavior ◽  
Drug Release Behavior

Supramolecular, prodrug-based micelles with enzyme-regulated release behavior for controlled drug delivery

MedChemComm ◽  
2015 ◽  
Vol 6 (10) ◽  
pp. 1874-1881 ◽  
Author(s):  
Yongyong Li ◽  
Yuqin Chen ◽  
Haiqing Dong ◽  
Chunyan Dong
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Controlled Drug Delivery ◽  
Release Behavior ◽  
Drug Release Behavior

Supramolecular, prodrug-based micelles (SMPMs) with enzyme-induced drug release behavior were engineeredviahost–guest interaction of camptothecin carrying PCL and α-cyclodextrin.

scholarly journals pH-Sensitive Starch-Based Hydrogels: Synthesis and Effect of Molecular Components on Drug Release Behavior

Polymers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 1974
Author(s):  
Juan Carlos Quintanilla de Stéfano ◽  
Vanessa Abundis-Correa ◽  
Sergio Daniel Herrera-Flores ◽  
Alejandro J. Alvarez
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Release Rate ◽  
Crosslinking Agent ◽  
Ph Sensitive ◽  
Fickian Diffusion ◽  
Butyl Methacrylate ◽  
Release Behavior ◽  
Drug Release Behavior ◽  
Swelling Capacity

The drug release behavior of pH-sensitive starch-based hydrogels was systematically studied. Hydrogels were synthesized by copolymerization of acrylic acid (AA) and other acrylate comonomers onto the starch backbone. The hydrophilic agents 2-hydroxy ethyl methacrylate (HEMA), and acrylamide (AAm), as well as the hydrophobic butyl-methacrylate (BMA), were utilized as comonomers. Methylene-bisacrylamide (MBA) was employed as a crosslinking agent. The synthesized hydrogels were loaded with caffeine as a model drug. The effects of the hydrophobic/hydrophilic character of the comonomers and chemical crosslinking on the swelling capacity and the release rate of caffeine were investigated. The use of the crosslinking agent and hydrophobic monomers decreased the swelling capacity of the hydrogels. The release rate of caffeine increased with the presence of a hydrophobic monomer. The fastest release was obtained with the AA/BMA/AAm formulation, and the slowest release was observed with the AA/HEMA/AAm formulation. The transport mechanism was controlled by Fickian diffusion in formulations containing AAm, and controlled by the polymer-relaxation mechanism in formulations containing MBA. Overall, our results showed that the swelling and drug delivery behavior can be tuned by varying the chemical composition of the copolymer formulations. These starch-based hydrogels can be useful as drug delivery devices in many biomedical applications.

Preparation of Eudragit® L Beads for Intragastric Floating Drug Delivery

2014 ◽  
Vol 1060 ◽  
pp. 79-82 ◽  
Author(s):  
Tassanee Nernplod ◽  
Prasert Akkaramongkolporn ◽  
Pornsak Sriamornsak
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Gastric Fluid ◽  
Cetyl Alcohol ◽  
Simulated Gastric Fluid ◽  
Release Behavior ◽  
Slight Effect ◽  
Drug Release Behavior ◽  
Floating Drug Delivery ◽  
Enteric Polymer

The aim of this study was to prepare matrix beads made of enteric polymer, Eudragit® L, metronidazole and various amounts of cetyl alcohol (0, 0.1 and 1%). Eudragit® L, metronidazole and cetyl alcohol were dissolved in acetone and then extruded into dichloromethane. The influence of amount of cetyl alcohol on floating and drug release behavior of matrix beads of Eudragit® L was investigated. The results showed that, after extruding, cetyl alcohol dissolved out from the beads already formed, resulting in a porous structure. Thus, the beads can float in simulated gastric fluid for more than 8 hours. Different amounts of cetyl alcohol had a slight effect on the drug release. However, the increased amount of cetyl alcohol in the formulations significantly sustained the drug release while the beads remained floating. The results suggest that Eudragit® L beads could be used as a carrier for intragastric floating drug delivery.

Synthesis and characterization of a solvent-based acrylate pressure adhesive for transdermal drug delivery

e-Polymers ◽  
2009 ◽  
Vol 9 (1) ◽  
Author(s):  
Fang Sun ◽  
Guoqiang. Zhu ◽  
Shunlai Li ◽  
Hongguang Du
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Transdermal Drug Delivery ◽  
Experimental Methodology ◽  
Polymerization Reaction ◽  
System Component ◽  
Release Behavior ◽  
Drug Release Behavior ◽  
Transdermal Drug Delivery Systems ◽  
Peel Adhesion

AbstractThe present investigation was directed towards the synthesis of a copolymer of vinyl acetate, butyl acrylate, 2-ethylhexyl acrylate, methacrylic acid and acrylamide to be exploited as a pressure sensitive adhesive (PSA) in transdermal drug delivery systems. The experimental methodology involved the optimization of reaction conditions for the polymer synthesis. The optimal synthesis conditions of PSA were determined as that polymerization reaction of PSA in ethyl acetate with BPO of 0.5% w/w of reactants at 75 oC throughout the whole process with polymerization reaction time of eight hours. The copolymer was then characterized by FTIR, 1H-NMR, 13C-NMR and DSC. The PSA was also evaluated for residual monomer content, viscosity, tack, peel adhesion and drug release behavior. The synthesized PSA’s tack is 21#; peel adhesion is 1.39 N/mm. And the residual monomers content in the copolymer after polymerizing for eight hours are VAc 2.98%, BA 0.004%. The PSA also exhibited excellent drug release behavior. Membranes containing oxybutynin were capable of releasing in zero order fashion. It was found that the release velocity depended on the concentration of modified monomer. Drug release from those membranes could be easily tailored by changing the content of the modified monomers. It was found suitable for use in transdermals and could be further exploited either as an adhesive or as a system component in the area of transdermal drug delivery.

Development and characterization of sodium alginate/poly(sodium 4-styrenesulfonate) composite films for release behavior of ciprofloxacin hydrogen chloride monohydrate

2021 ◽  
pp. 096739112199027
Author(s):  
M Sohail Sarwar ◽  
Abdul Ghaffar ◽  
Qingrong Huang
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Composite Film ◽  
Sodium Alginate ◽  
Composite Films ◽  
Simulated Gastric Fluid ◽  
Release Behavior ◽  
Drug Release Behavior ◽  
Model Drug

Biopolymers, in particular polysaccharides, have attracted considerable interest in the field of drug delivery due to their biodegradable and biocompatible nature. This study is focused on the preparation and characterization of drug delivery devices based on sodium alginate (SA) composite films with poly(sodium 4-styrenesulfonate) (PSS). The prepared composite films were characterized for the determination of physiochemical properties, molecular interactions, and drug release behavior. The possible intermolecular hydrogen bonding between SA and PSS was determined by ATR-FTIR spectroscopy. Surface characterization was done using AFM. Polymeric films consisted of pristine SA and PSS exhibited relatively uniform and flat surfaces. However, the composite films showed phase separation that became more prominent as the concentration of PSS in the composite films was increased up to 40% (w/w). The contact angle (CA) values, using deionized water as a function of time (s), were ranging from 74° to 90°, and a decrease in CA (64° to 76°) was recorded for each composite film till 40 s. These CA values revealed that all the composite films were hydrophobic. It was observed that as the concentration of PSS in the films increased, hydrophobicity slightly varied as compared to the blank films of SA and PSS. Maximum CA (89°) was shown by a composite film having SA/PSS (90/10). Ciprofloxacin hydrochloride monohydrate (CPX), a model drug, loaded in a suitable composite film (cross-linked with 0.3 M CaCl2 solution) and drug release was evaluated in pH 1.2 simulated gastric fluid (SGF) and pH 7.4 phosphate buffer saline (PBS) solution. In SGF, around 90% of the model drug was released in 110 min that was approximately 77% in the case of PBS. Therefore, it was concluded that a sustained drug release behavior was exhibited in SGF as compared to PBS solution. These results suggest that these films are a promising and may potentially be subjected to study further their drug delivery behavior in applications like wound dressing. [Formula: see text]

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