Synthesis of a Nanostructured Star Block Copolymer with a Cyclotriphosphazene Core

2006 ◽  
Vol 6 (11) ◽  
pp. 3446-3449
Author(s):  
Jae Kook Han ◽  
Sung Tae Kim ◽  
Hyun Jung Kim ◽  
Yong Ku Kwon
Keyword(s):  
Lactic Acid ◽  
Block Copolymer ◽  
Ethylene Glycol ◽  
Sodium Salt ◽  
Star Polymer ◽  
Poly Ethylene Glycol ◽  
Block Polymer ◽  
Star Block Copolymer ◽  
Poly Ethylene ◽  
Glycol Methyl Ether

An amphiphilic star block copolymer of poly(L-lactic acid)-b-poly(ethylene glycol) (PLLA-b-PEG) was synthesized using a hexachlorocyclotriphosphazene ring (N3P3Cl6) as a core. N3P3(OC6H4-p-CHO)6 was prepared by the reaction between the hexachlorocyclotriphosphazene core and 4-hydroxybenzaldehyde sodium salt. N3P3(OC6H4-p-CH2OH)6 was then obtained by reduction of N3P3(OC6H4-p-CHO)6. N3P3(OC6H4-p-CH2OH)6 was used as an initiator to obtain a PLLA-grafted star branched polymer by polymerizing lactide, which was then treated with succinic acid to produce a carboxylated PLLA-grafted star polymer. PEG blocks were attached to a carboxylated PLLA-grafted star polymer to produce an amphiphilic PLLA-b-PEG-grafted star block polymer by additional esterification with poly(ethylene glycol methyl ether).

Controlling the morphology of glyco-nanoparticles in water using block copolymer mixtures: the effect on cellular uptake

2015 ◽  
Vol 6 (45) ◽  
pp. 7812-7820 ◽  
Author(s):  
Aydan Dag ◽  
Hongxu Lu ◽  
Martina Stenzel
Keyword(s):  
Block Copolymer ◽  
Ethylene Glycol ◽  
Cellular Uptake ◽  
Methyl Ether ◽  
Butyl Acrylate ◽  
Diblock Copolymers ◽  
Ethyl Acrylate ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Glycol Methyl Ether

Poly[(2-(α-d-mannosyloxy)ethyl acrylate)-block-(n-butyl acrylate)], P(ManA-b-BA), and poly[poly(ethylene glycol) methyl ether acrylate]-block-(n-butyl acrylate)], P(OEGMEA-b-BA) diblock copolymers were mixed at various ratios to generate self-assembled structures of different morphologies.

Fluorinated amphiphilic block copolymers via RAFT polymerization and their application as surf-RAFT agent in miniemulsion polymerization

RSC Advances ◽  
2015 ◽  
Vol 5 (20) ◽  
pp. 15461-15468 ◽  
Author(s):  
Bishnu P. Koiry ◽  
Arindam Chakrabarty ◽  
Nikhil K. Singha
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Ethylene Glycol ◽  
Raft Polymerization ◽  
Miniemulsion Polymerization ◽  
Amphiphilic Block Copolymers ◽  
Poly Ethylene Glycol ◽  
Raft Agent ◽  
Poly Ethylene ◽  
Glycol Methyl Ether

Preparation of an amphiphilic block copolymer (Am-BCP) based on poly(ethylene glycol) methyl ether methacrylate (PEGMA) and heptafluorobutyl acrylate (HFBA) via RAFT polymerization and application of this Am-BCP as surf-RAFT agent for polymerization of styrene.

The dual-role of Pt(iv) complexes as active drug and crosslinker for micelles based on β-cyclodextrin grafted polymer

2016 ◽  
Vol 4 (12) ◽  
pp. 2114-2123 ◽  
Author(s):  
Manuela Callari ◽  
Donald S. Thomas ◽  
Martina H. Stenzel
Keyword(s):  
Bile Acid ◽  
Block Copolymer ◽  
Ethylene Glycol ◽  
Methyl Ether ◽  
Active Drug ◽  
Poly Ethylene Glycol ◽  
Grafted Polymer ◽  
Poly Ethylene ◽  
Glycol Methyl Ether

Amphiphilic block copolymer based on poly(ethylene glycol) methyl ether methacrylate (POEGMEMA) and a block with pendant cyclodextrin units were self-assembled into micelles in the presence of the hydrophobic bile acid-based Pt(IV) drug, which also acted as crosslinker.

Poly(lactic acid)/poly(ethylene glycol) block copolymer based shell or core cross-linked micelles for controlled release of hydrophobic drug

RSC Advances ◽  
2015 ◽  
Vol 5 (25) ◽  
pp. 19484-19492 ◽  
Author(s):  
Junjie Li ◽  
Shuangzhuang Guo ◽  
Min Wang ◽  
Lei Ye ◽  
Fanglian Yao
Keyword(s):  
Lactic Acid ◽  
Block Copolymer ◽  
Ethylene Glycol ◽  
Poly Lactic Acid ◽  
Release Behavior ◽  
Hydrophobic Drug ◽  
Poly Ethylene Glycol ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles ◽  
Poly Ethylene

The syntheses, structures, and drug release behavior of shell or core cross-linked poly(lactic acid)/poly(ethylene glycol) block copolymer micelles.

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