scholarly journals Nano Drug Deliverer for Ampicillin, Clavulanic Acid, Imipenem, Penicillin G and Ticarcillin

2016 ◽  
Vol 13 (10) ◽  
pp. 7144-7155
Author(s):  
Maryam Derakhshandeh ◽  
Majid Monajjemi
Keyword(s):  
Drug Delivery ◽  
Clavulanic Acid ◽  
Large Scale ◽  
Penicillin G ◽  
Effect Of Temperature ◽  
Phenoxyacetic Acid ◽  
Scale Production ◽  
Electronic Effects ◽  
Beta Lactam ◽  
Gram Positive

Ampicillin, Clavulanic acid, Imipenem, Penicillin G and Ticarcillin properties for the drug delivery with binding to SWCNNTs and SWBNNTs have been studied. Penicillin and its alteration Penicillin G or phenoxyacetic acid for Penicillin V is used for large scale production. Penicillin and other cell wall inhibitors are primarily specific against Gram positive bacteria because of higher percentage of peptidoglycan in the cell walls of these organisms. Ampicillin belonging to the penicillin group of beta lactam antibiotics, ampicillin is able to penetrate Gram positive and some Gram-negative bacteria. Imipenem (Primaxin) is an intravenous β-lactam antibiotic discovered by Merck scientists Burton Christensen, William Leanza, and Kenneth Wildonger in 1980. It was the first member of the carbapenem class of antibiotics. Based on our previous works we have modeled and simulated a drug delivery system of those antibiotics. The investigation of those antibiotics in binding with single-walled carbon nanotube (SWCNT) and SWBNNTs have been studied by theoretical methods. It has been established the best structural and functional of those antibiotics. A number of computational chemistry studies carried out to understand the conformational preferences that may be attributed to stereo electronic effects. These results show the minimized structure of mentioned antibiotics with SWCNTs and SWBNNTs, calculated potential energy for important dihedral angles, and the effect of temperature on geometry of optimized structure. NMR by GIAO approximation, have been applied for determination of the situation in antibiotics-SWCNT and shifting. This model provides an atomistic analysis of the antibiotics-SWCNT strategy and its implications for further investigations of drugs.

scholarly journals Nano drug deliverer for ampicillin, clavulanic acid, imipenem, penicillin g and ticarcillin

2020 ◽  
Vol 33 (01) ◽  
pp. 121-136
Author(s):  
Maryam Derakhshandeh ◽  
Majid Monajjemi
Keyword(s):  
Drug Delivery ◽  
Clavulanic Acid ◽  
Large Scale ◽  
Penicillin G ◽  
Phenoxyacetic Acid ◽  
Scale Production ◽  
Beta Lactam ◽  
Gram Positive ◽  
Beta Lactam Antibiotics ◽  
Lactam Antibiotic

Ampicillin belonging to the penicillin group of beta lactam antibiotics. Ampicillin is able to penetrate Gram positive and some Gram-negative bacteria. Imipenem (Primaxin) is an intravenous β-lactam antibiotic discovered by Merck scientists Burton Christensen, William Leanza, and Kenneth Wildonger in 1980 Ampicillin, Clavulanic acid, Imipenem, Penicillin G and Ticarcillin properties for the drug delivery with binding to SWCNNTs and SWBNNTs have been studied. Penicillin and its alteration Penicillin G or phenoxyacetic acid for Penicillin V is used for large scale production. Penicillin and other cell wall inhibitors are primarily specific against Gram positive bacteria because of higher percentage of peptidoglycan in the cell walls of these organisms. It was the first member of the carbapenem class of antibiotics. Based on our previous works we have modeled and simulated a drug delivery system of those antibiotics. The investigation of those antibiotics in binding with single-walled carbon nanotube (SWCNT) and SWBNNTs have been studied by theoretical methods. It has been established the best structural and functional of those antibiotics.

Solid Lipid Nanoparticles: A Promising Drug Delivery Technology

2009 ◽  
Vol 2 (2) ◽  
pp. 509-516
Author(s):  
S. Pragati ◽  
S. Kuldeep ◽  
S. Ashok ◽  
M. Satheesh
Keyword(s):  
Drug Delivery ◽  
Solid Lipid Nanoparticles ◽  
Large Scale ◽  
Colloidal Particles ◽  
Scale Up ◽  
Lipid Nanoparticles ◽  
Scale Production ◽  
Research Activity ◽  
New Approach ◽  
Solid Lipid

One of the situations in the treatment of disease is the delivery of efficacious medication of appropriate concentration to the site of action in a controlled and continual manner. Nanoparticle represents an important particulate carrier system, developed accordingly. Nanoparticles are solid colloidal particles ranging in size from 1 to 1000 nm and composed of macromolecular material. Nanoparticles could be polymeric or lipidic (SLNs). Industry estimates suggest that approximately 40% of lipophilic drug candidates fail due to solubility and formulation stability issues, prompting significant research activity in advanced lipophile delivery technologies. Solid lipid nanoparticle technology represents a promising new approach to lipophile drug delivery. Solid lipid nanoparticles (SLNs) are important advancement in this area. The bioacceptable and biodegradable nature of SLNs makes them less toxic as compared to polymeric nanoparticles. Supplemented with small size which prolongs the circulation time in blood, feasible scale up for large scale production and absence of burst effect makes them interesting candidates for study. In this present review this new approach is discussed in terms of their preparation, advantages, characterization and special features.

scholarly journals Antimicrobial Susceptibility of Clinically Relevant Gram-Positive Anaerobic Cocci Collected over a Three-Year Period in the Netherlands

2010 ◽  
Vol 55 (3) ◽  
pp. 1199-1203 ◽  
Author(s):  
A. C. M. Veloo ◽  
G. W. Welling ◽  
J. E. Degener
Keyword(s):  
The Netherlands ◽  
Clavulanic Acid ◽  
Antimicrobial Susceptibility ◽  
Penicillin G ◽  
Correct Identification ◽  
Gram Positive ◽  
Parvimonas Micra ◽  
Amoxicillin Clavulanic Acid

ABSTRACTThe susceptibility of 14 species of 115 Gram-positive anaerobic cocci (GPAC) was determined for 14 antibiotics. To assure correct identification, strains were genotypically identified by fluorescencein situhybridization and sequencing. Susceptibility differences (MIC50and MIC90) for penicillin G, clindamycin, tigecycline, levofloxacin, amoxicillin-clavulanic acid, cefoxitin, ertapenem, meropenem, metronidazole, and doxycycline were found for the three clinically most relevant GPAC species:Finegoldia magna,Parvimonas micra, andPeptoniphilus harei.

scholarly journals Pharmaceutical Particles Design by Membrane Emulsification: Preparation Methods and Applications in Drug Delivery

2017 ◽  
Vol 23 (2) ◽  
pp. 302-318 ◽  
Author(s):  
Emma Piacentini ◽  
Marijana Dragosavac ◽  
Lidietta Giorno
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Rational Design ◽  
Large Scale ◽  
Drug Loading ◽  
Small Scale ◽  
Scale Production ◽  
Membrane Emulsification ◽  
Preparation Methods ◽  
Promising Tool

Nowadays, the rational design of particles is an important issue in the development of pharmaceutical medicaments. Advances in manufacturing methods are required to design new pharmaceutical particles with target properties in terms of particle size, particle size distribution, structure and functional activity. Membrane emulsification is emerging as a promising tool for the production of emulsions and solidified particles with tailored properties in many fields. In this review, the current use of membrane emulsification in the production of pharmaceutical particles is highlighted. Membrane emulsification devices designed for small-scale testing as well as membrane-based methods suitable for large-scale production are discussed. A special emphasis is put on the important factors that contribute to the encapsulation efficiency and drug loading. The most recent studies about the utilization of the membrane emulsification for preparing particles as drug delivery systems for anticancer, proteins/peptide, lipophilic and hydrophilic bioactive drugs are reviewed.

Raman spectroscopy in pharmaceutical research and industry

2018 ◽  
Vol 3 (8) ◽  
Author(s):  
Nathalie Jung ◽  
Maike Windbergs
Keyword(s):  
Drug Delivery ◽  
Raman Spectroscopy ◽  
Quality Control ◽  
Drug Delivery Systems ◽  
Large Scale ◽  
Pharmaceutical Research ◽  
Delivery Systems ◽  
Scale Production ◽  
Non Invasive ◽  
Large Scale Production

Abstract In the fast-developing fields of pharmaceutical research and industry, the implementation of Raman spectroscopy and related technologies has been very well received due to the combination of chemical selectivity and the option for non-invasive analysis of samples. This chapter explores established and potential applications of Raman spectroscopy, confocal Raman microscopy and related techniques from the early stages of drug development research up to the implementation of these techniques in process analytical technology (PAT) concepts for large-scale production in the pharmaceutical industry. Within this chapter, the implementation of Raman spectroscopy in the process of selection and optimisation of active pharmaceutical ingredients (APIs) and investigation of the interaction with excipients is described. Going beyond the scope of early drug development, the reader is introduced to the use of Raman techniques for the characterization of complex drug delivery systems, highlighting the technical requirements and describing the analysis of qualitative and quantitative composition as well as spatial component distribution within these pharmaceutical systems. Further, the reader is introduced to the application of Raman techniques for performance testing of drug delivery systems addressing drug release kinetics and interactions with biological systems ranging from single cells up to complex tissues. In the last part of this chapter, the advantages and recent developments of integrating Raman technologies into PAT processes for solid drug delivery systems and biologically derived pharmaceutics are discussed, demonstrating the impact of the technique on current quality control standards in industrial production and providing good prospects for future developments in the field of quality control at the terminal part of the supply chain and various other fields like individualized medicine. On the way from the active drug molecule (API) in the research laboratory to the marketed medicine in the pharmacy, therapeutic efficacy of the active molecule and safety of the final medicine for the patient are of utmost importance. For each step, strict regulatory requirements apply which demand for suitable analytical techniques to acquire robust data to understand and control design, manufacturing and industrial large-scale production of medicines. In this context, Raman spectroscopy has come to the fore due to the combination of chemical selectivity and the option for non-invasive analysis of samples. Following the technical advancements in Raman equipment and analysis software, Raman spectroscopy and microscopy proofed to be valuable methods with versatile applications in pharmaceutical research and industry, starting from the analysis of single drug molecules as well as complex multi-component formulations up to automatized quality control during industrial production.

scholarly journals A Comprehensive Review on Self-Nano Emulsifying Drug Delivery Systems: Advancements & Applications

2020 ◽  
pp. 576-583
Author(s):  
Srikanth Reddy Sokkula ◽  
Suresh Gande
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Large Scale ◽  
Antihypertensive Drugs ◽  
Drug Loading ◽  
Delivery Systems ◽  
Water Soluble ◽  
Scale Production ◽  
Advantages And Disadvantages ◽  
Water Soluble Drugs

Lipid-based drug delivery systems are extensively reported in literature for enhancing the drug solubility, permeability and bioavailability. These systems include   simple oil solutions, coarse, multiple and dry emulsions, complex self-emulsifying, microemulsifying or nanoemulsifying drug delivery systems. Self-emulsifying systems are further classified as self-microemulsifying drug delivery systems (SMEDDS) and self-nanoemulsifying drug delivery systems (SNEDDS) are most prevailing and commercially viable oil based approach for drugs that exhibit low dissolution rate and inadequate absorption. Ever since the progress of SNEDDS, they drew the interest of researchers in order to deal with the challenges of poorly water-soluble drugs. SNEDDS is a proven method for enhancing solubility and bioavailability of lipophilic compounds. Considering the ease of large-scale production and the robustness of SNEDDS, several formulations techniques are commercially available. The stability of SNEDDS can be further enhanced by solidifying liquid SNEDDS. Controlled release and supersaturated SNEDDS received patient compliance with larger drug loading. Presence of biodegradable ingredients and ‘drug-targeting opportunities’ facilitate SNEDDS a clear merit and distinction amongst available solubility enhancement techniques. In this article attempt was made to present an overview of SNEDDS, their mechanism, formulation excipients and potentials of SNEDDS, recent advancements, advantages and disadvantages of SNEDDS formulations. The article also focuses on reviewing the application of SNEDDS in enhancing bioavailability of antihypertensive drugs.

scholarly journals Influence of Temperature on Selected Life-History Traits of Black Soldier Fly (Hermetia illucens) Reared on Two Common Urban Organic Waste Streams in Kenya

Animals ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 79 ◽  
Author(s):  
Marwa Shumo ◽  
Fathiya Khamis ◽  
Chrysantus Tanga ◽  
Komi Fiaboe ◽  
Sevgan Subramanian ◽  
...  
Keyword(s):  
Larval Development ◽  
Large Scale ◽  
Sub Saharan Africa ◽  
Effect Of Temperature ◽  
Cow Dung ◽  
Scale Production ◽  
Organic Substrates ◽  
Waste Streams ◽  
Black Soldier Fly ◽  
Livestock Feed

In sub-Saharan Africa, urban populations are projected to increase by 115% in the coming 15 years. In addition, economic growth and dietary shifts towards animal source foods have put high pressure and demand on agricultural production. The high ecological footprint of meat and dairy production, as well as high feed costs, prevent the livestock sector from meeting the increasing demand in a sustainable manner. Insects such as the black soldier fly (BSF) have been identified as potential alternatives to the conventionally used protein sources in livestock feed due to their rich nutrient content and the fact that they can be reared on organic side streams. Substrates derived from organic byproducts are suitable for industrial large-scale production of insect meal. Although efficient in waste management and in feed production, BSF larvae are very sensitive to the external environment such as temperature and rearing medium. Therefore, we studied the effect of temperature and substrate type, i.e., brewers’ spent grain (SG) and cow dung (CD), on the development and survival of BSF larvae. Both organic substrates were readily available in Nairobi, Kenya, the location of the experiments. In our experiment, 100 3–5-day-old BSF larvae were placed into containers that contained either SG or CD and further treated at temperatures of 15 °C, 20 °C, 25 °C, 30 °C, and 35 °C. The duration of larval development was recorded, and the prepupae were removed, weighed, and placed individually in separate, labeled, 35-mL plastic cups filled with moist sawdust. After emergence, 10 2-day-old adults (5 males and 5 females) from every replica per substrate were transferred into a cage (40 × 40 × 40 cm) and allowed to mate for 24 h at their respective temperatures. The laid egg batches were collected and counted, and the adult flies’ longevity was recorded. The data were subjected to a two-way analysis of variance (ANOVA) using the general linear model procedure. BSF larvae reared on SG developed faster than those reared on CD; the former also favored higher temperatures for their larval development and emergence into adults. The optimum range was 25–30 °C. With increasing temperatures, the longevity of adult BSF decreased, while the fecundity of females increased. Thus, it is possible to take advantage of the readily available SG waste streams in the urban environments of Kenya to produce BSF larvae-derived livestock feed within a short duration of time and at relatively high temperatures.

scholarly journals Kageneckia oblonga Leaves Subjected to Different Drying Methods: Drying Kinetics, Energy Consumption and Interesting Compounds

2021 ◽  
Vol 5 ◽  
Author(s):  
Carlos Zambra ◽  
Diógenes Hernández ◽  
Hugo Reyes ◽  
Nicole Riveros ◽  
Roberto Lemus-Mondaca
Keyword(s):  
Energy Consumption ◽  
Large Scale ◽  
Moisture Diffusivity ◽  
Convective Drying ◽  
Effect Of Temperature ◽  
Drying Methods ◽  
Scale Production ◽  
Large Scale Production ◽  
Drying Curves ◽  
Drying Conditions

In this study, Kageneckia oblonga leaves were dried under different drying conditions and techniques [oven drying (NC), vacuum drying (VNC), convective drying (FC), and microwave-assisted convective drying (MWFC)]. Thus, the effect of temperature, vacuum, and microwave on the drying features of K. oblonga leaves was determined. Fick's second law was used to calculate the effective moisture diffusivity that varied from 3.94 to 8.14 × 10−11 m2/s, 1.12 to 1.40 × 10−11 m2/s, 7.83 to 11.36 × 10−11 m2/s, and 6.93 to 16.72 × 10−11 m2/s for NC, VNC, FC, and MWFC methods, respectively. In addition, the Weibull and Midilli–Kucuk models accurately predicted all experimental drying curves of K. oblonga leaves. Regarding the energy consumption and efficiency values for different drying methods of K. oblonga were found to be in the range of 0.20–7.50 kW·h and 0.10–3.70%, respectively. The results showed that MWFC method does not significantly affect the phenolic compounds and could be used for large-scale production of K. oblonga dried leaves.

scholarly journals Red Blood Cell Extracellular Vesicle-Based Drug Delivery: Challenges and Opportunities

2021 ◽  
Vol 8 ◽  
Author(s):  
Wararat Chiangjong ◽  
Pukkavadee Netsirisawan ◽  
Suradej Hongeng ◽  
Somchai Chutipongtanate
Keyword(s):  
Drug Delivery ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Large Scale ◽  
Regulatory Protein ◽  
Extracellular Vesicle ◽  
Clinical Applications ◽  
Target Cells ◽  
Scale Production ◽  
Advantages And Disadvantages

Recently, red blood cell-derived extracellular vesicles (RBCEVs) have attracted attention for clinical applications because of their safety and biocompatibility. RBCEVs can escape macrophages through the binding of CD47 to inhibitory receptor signal regulatory protein α. Furthermore, genetic materials such as siRNA, miRNA, mRNA, or single-stranded RNA can be encapsulated within RBCEVs and then released into target cells for precise treatment. However, their side effects, half-lives, target cell specificity, and limited large-scale production under good manufacturing practice remain challenging. In this review, we summarized the biogenesis and composition of RBCEVs, discussed the advantages and disadvantages of RBCEVs for drug delivery compared with synthetic nanovesicles and non-red blood cell-derived EVs, and provided perspectives for overcoming current limitations to the use of RBCEVs for clinical applications.

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