Identify the Source of Osteoblasts and Osteogenic Signaling Pathway During Bone Induction in Mice

2019 ◽  
Vol 9 (4) ◽  
pp. 485-491 ◽  
Author(s):  
Lijia Cheng ◽  
Liming Yang ◽  
Bei Niu ◽  
Shuo Yan ◽  
Zheng Shi ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Bone Induction ◽  
Osteogenic Signaling

Icariin Accelerates Fracture Healing via Activation of the WNT1/β-catenin Osteogenic Signaling Pathway

2020 ◽  
Vol 21 (15) ◽  
pp. 1645-1653
Author(s):  
Xiao-Yun Zhang ◽  
Yue-Ping Chen ◽  
Chi Zhang ◽  
Xuan Zhang ◽  
Tian Xia ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Bone Formation ◽  
Fracture Healing ◽  
Bone Morphogenetic Protein ◽  
Signaling Pathway ◽  
Type I Collagen ◽  
Type I ◽  
Alp Activity ◽  
Morphogenetic Protein ◽  
Osteogenic Signaling

Background: Icariin has been shown to enhance bone formation. Objective: The present study aimed to investigate whether icariin also promotes bone fracture healing and its mechanisms. Methods: First, we isolated and cultured rat bone marrow stromal cells (rBMSCs) with icariincontaining serum at various concentrations (0%, 2.5%, 5% and 10%) and then measured alkaline phosphatase (ALP) activity and the expression of Core-binding factor, alpha 1 (Cbfα1), bone morphogenetic protein-2 (BMP-2) and bone morphogenetic protein-4 (BMP-4) in the rBMSCs. Second, we established a model of fracture healing in rats and performed gavage treatment for 20 days. Then, we detected bone biochemical markers (ELISA kits) in the serum, fracture healing (digital radiography, DR), and osteocalcin expression (immunohistochemistry). Results: Icariin treatment increased ALP activity and induced the expression of Cbfα1, BMP-2 and BMP-4 in rBMSCs in a dose-dependent manner. In addition, Icariin increased the serum levels of osteocalcin (OC), bone-specific alkaline phosphatase (BAP), N-terminal telopeptides of type I collagen (NTX-1), C-terminal telopeptide of type I collagen (CTX-1) and tartrate-resistant acid phosphatase 5b (TRACP-5b); promoted osteocalcin secretion at the fracture site; and accelerated fracture healing. Conclusions: Icariin can promote the levels of bone-formation markers, accelerate fracture healing, and activate the WNT1/β-catenin osteogenic signaling pathway.

Wnt signaling pathway regulates the differentiation of hepatic progenitor cells

2010 ◽  
Vol 34 (8) ◽  
pp. S41-S41
Author(s):  
Yang Bi ◽  
Yun He ◽  
Tingyu Li ◽  
Tao Feng ◽  
Tongchuan He
Keyword(s):  
Wnt Signaling ◽  
Progenitor Cells ◽  
Signaling Pathway ◽  
Wnt Signaling Pathway ◽  
Hepatic Progenitor Cells

285: The Role of the NF-κB Signaling Pathway in the Pathogenesis of Interstitial Cystitis

2006 ◽  
Vol 175 (4S) ◽  
pp. 95-95
Author(s):  
Raymond R. Rackley ◽  
Mei Kuang ◽  
Ashwin A. Vaze ◽  
Joseph Abdelmalak ◽  
Sandip P. Vasavada ◽  
...  
Keyword(s):  
Interstitial Cystitis ◽  
Signaling Pathway

417: The Human Androgen Receptor Gene is a Primary Target of the WNT Signaling Pathway

2006 ◽  
Vol 175 (4S) ◽  
pp. 136-136
Author(s):  
Ralph Buttyan ◽  
Xuezhen Yang ◽  
Min-Wei Chen ◽  
Debra L. Bemis ◽  
Mitchell C. Benson ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Receptor Gene ◽  
Wnt Signaling Pathway ◽  
Androgen Receptor Gene ◽  
Primary Target ◽  
Human Androgen Receptor Gene ◽  
Human Androgen Receptor

1451: Positive Efect of Prostaglandin on Regulation of Prostate Blood Flow-Investigation of the Key Factor in the Signaling Pathway of The Prostate Blood Flow-

2005 ◽  
Vol 173 (4S) ◽  
pp. 393-393
Author(s):  
Bunzo Kashiwagi ◽  
Yasuhiro Shibata ◽  
Kazunari Ohki ◽  
Seiji Arai ◽  
Seijiro Honma ◽  
...  
Keyword(s):  
Blood Flow ◽  
Signaling Pathway ◽  
Flow Investigation ◽  
Key Factor

P 53 and p56: A new signaling pathway in human endometrium and endometrial adenocarcinomas

1997 ◽  
Vol 4 (2) ◽  
pp. 103-109
Author(s):  
G COUCHMAN ◽  
R BENTLEY ◽  
M TSAO ◽  
K RASZMANN ◽  
J MCLACHLAN ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Human Endometrium ◽  
P 53
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