Bone Marrow Mesenchymal Stem Cells Differentiate Into Functional Tracheal Epithelial Cells by Air-Liquid Interface Culture Conditions

2016 ◽  
Vol 6 (8) ◽  
pp. 613-620
Author(s):  
Yan-Ling Chen ◽  
Shao-Ru He ◽  
Jian Zhuang ◽  
Liang Chen ◽  
Yi-Fei Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Epithelial Cells ◽  
Culture Conditions ◽  
Liquid Interface ◽  
Tracheal Epithelial Cells ◽  
Marrow Mesenchymal Stem Cells ◽  
Tracheal Epithelial ◽  
Air Liquid Interface

scholarly journals Bone Marrow Mesenchymal Stem Cells Ameliorate Cisplatin-Induced Renal Fibrosis via miR-146a-5p/Tfdp2 Axis in Renal Tubular Epithelial Cells

2021 ◽  
Vol 11 ◽  
Author(s):  
Lei Wu ◽  
Chao Rong ◽  
Qing Zhou ◽  
Xin Zhao ◽  
Xue-Mei Zhuansun ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Epithelial Cells ◽  
Renal Fibrosis ◽  
Kidney Diseases ◽  
Tubular Epithelial Cells ◽  
Renal Tubular Epithelial Cells ◽  
Marrow Mesenchymal Stem Cells ◽  
Renal Tubular

Mesenchymal stem cells (MSCs) have regenerative properties in acute kidney injury (AKI). However, the potential function of MSCs in chronic kidney disease remains elusive. Renal fibrosis is the common endpoint of chronic progressive kidney diseases and causes a considerable health burden worldwide. In this study, the protective effects of bone marrow mesenchymal stem cells (BM-MSCs) were assessed in repeated administration of low-dose cisplatin-induced renal fibrosis mouse model in vivo as well as a TGF-β1-induced fibrotic model in vitro. Differentially expressed miRNAs in mouse renal tubular epithelial cells (mRTECs) regulated by BM-MSCs were screened by high-throughput sequencing. We found microRNA (miR)-146a-5p was the most significant up-regulated miRNA in mRTECs. In addition, the gene Tfdp2 was identified as one target gene of miR-146a-5p by bioinformatics analysis. The expression of Tfdp2 in the treatment of BM-MSCs on cisplatin-induced renal injury was evaluated by immunohistochemistry analysis. Our results indicate that BM-MSC attenuates cisplatin-induced renal fibrosis by regulating the miR-146a-5p/Tfdp2 axis in mRTECs.

Secretion of rat tracheal epithelial cells induces mesenchymal stem cells to differentiate into epithelial cells

2011 ◽  
Vol 36 (2) ◽  
pp. 169-175 ◽  
Author(s):  
Zhaorui Sun ◽  
Yajing Wang ◽  
Xuemin Gong ◽  
Hang Su ◽  
Xiaodong Han
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Epithelial Cells ◽  
Tracheal Epithelial Cells ◽  
Tracheal Epithelial
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