Self-Assembled Hyaluronic Acid Nanoparticles for pH-Sensitive Release of Doxorubicin: Synthesis and In Vitro Characterization

2017 ◽  
Vol 13 (9) ◽  
pp. 1058-1068 ◽  
Author(s):  
Rui Hu ◽  
Hua Zheng ◽  
Jun Cao ◽  
Zahra Davoudi ◽  
Qun Wang
Keyword(s):  
Hyaluronic Acid ◽  
Ph Sensitive ◽  
In Vitro Characterization ◽  
Self Assembled

scholarly journals Diacerein-Loaded Hyaluosomes as a Dual-Function Platform for Osteoarthritis Management via Intra-Articular Injection: In Vitro Characterization and In Vivo Assessment in a Rat Model

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 765
Author(s):  
Nouran O. Abdelmageed ◽  
Nadia M. Morsi ◽  
Rehab N. Shamma
Keyword(s):  
Hyaluronic Acid ◽  
Cartilage Damage ◽  
Entrapment Efficiency ◽  
Dual Function ◽  
In Vitro Characterization ◽  
Drug Entrapment Efficiency ◽  
Formulation Parameters ◽  
Acid Gel

The application of intra-articular injections in osteoarthritis management has gained great attention lately. In this work, novel intra-articular injectable hyaluronic acid gel-core vesicles (hyaluosomes) loaded with diacerein (DCN), a structural modifying osteoarthritis drug, were developed. A full factorial design was employed to study the effect of different formulation parameters on the drug entrapment efficiency, particle size, and zeta potential. Results showed that the prepared optimized DCN- loaded hyaluosomes were able to achieve high entrapment (90.7%) with a small size (310 nm). The morphology of the optimized hyaluosomes was further examined using TEM, and revealed spherical shaped vesicles with hyaluronic acid in the core. Furthermore, the ability of the prepared DCN-loaded hyaluosomes to improve the in vivo inflammatory condition, and deterioration of cartilage in rats (injected with antigen to induce arthritis) following intra-articular injection was assessed, and revealed superior function on preventing cartilage damage, and inflammation. The inflammatory activity assessed by measuring the rat’s plasma TNF-α and IL-1b levels, revealed significant elevation in the untreated group as compared to the treated groups. The obtained results show that the prepared DCN-loaded hyaluosomes would represent a step forward in the design of novel intra articular injection for management of osteoarthritis.

scholarly journals Novel gelatin-polyoxometalate based self-assembled pH responsive hydrogels: formulation and in vitro characterization

2016 ◽  
Vol 19 (8) ◽  
pp. 697-705 ◽  
Author(s):  
Azizullah ◽  
Nisar-ur-Rehman ◽  
Wenjing Liu ◽  
Ali Haider ◽  
Ulrich Kortz ◽  
...  
Keyword(s):  
Ph Responsive ◽  
In Vitro Characterization ◽  
Self Assembled ◽  
Responsive Hydrogels

In vitro characterization of pH-sensitive Bletilla Striata polysaccharide copolymer micelles and enhanced tumour suppression in vivo

2018 ◽  
Vol 70 (6) ◽  
pp. 797-807 ◽  
Author(s):  
Lichun Zhao ◽  
Dandan Sun ◽  
Haibin Lu ◽  
Bing Han ◽  
Guangyuan Zhang ◽  
...  
Keyword(s):  
Ph Sensitive ◽  
Bletilla Striata ◽  
Tumour Suppression ◽  
In Vitro Characterization ◽  
Copolymer Micelles
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