scholarly journals Mucin-1-Antibody-Conjugated Mesoporous Silica Nanoparticles for Selective Breast Cancer Detection in a Mucin-1 Transgenic Murine Mouse Model

2016 ◽  
Vol 12 (12) ◽  
pp. 2172-2184 ◽  
Author(s):  
Didier Dréau ◽  
Laura Jeffords Moore ◽  
Merlis P. Alvarez-Berrios ◽  
Mubin Tarannum ◽  
Pinku Mukherjee ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mesoporous Silica ◽  
Mouse Model ◽  
Silica Nanoparticles ◽  
Cancer Detection ◽  
Mesoporous Silica Nanoparticles ◽  
Breast Cancer Detection ◽  
Mucin 1

Mucin1 antibody-conjugated dye-doped mesoporous silica nanoparticles for breast cancer detection in vivo

2017 ◽  
Author(s):  
Juan L. Vivero-Escoto ◽  
Laura Moore Jeffords ◽  
Didier Dréau ◽  
Merlis Alvarez-Berrios ◽  
Pinku Mukherjee
Keyword(s):  
Breast Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Detection ◽  
Mesoporous Silica Nanoparticles ◽  
Breast Cancer Detection

scholarly journals Cationic Polymer Modified Mesoporous Silica Nanoparticles for Targeted siRNA Delivery to HER2+Breast Cancer

2015 ◽  
Vol 25 (18) ◽  
pp. 2646-2659 ◽  
Author(s):  
Worapol Ngamcherdtrakul ◽  
Jingga Morry ◽  
Shenda Gu ◽  
David J. Castro ◽  
Shaun M. Goodyear ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Sirna Delivery ◽  
Cationic Polymer ◽  
Her2 Breast Cancer

scholarly journals Large Pore Mesoporous Silica and Organosilica Nanoparticles for Pepstatin A Delivery in Breast Cancer Cells

Molecules ◽  
2019 ◽  
Vol 24 (2) ◽  
pp. 332 ◽  
Author(s):  
Saher Rahmani ◽  
Jelena Budimir ◽  
Mylene Sejalon ◽  
Morgane Daurat ◽  
Dina Aggad ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Cathepsin D ◽  
Breast Cancer Cells ◽  
Potent Inhibitor ◽  
Mesoporous Silica Nanoparticles ◽  
Sol Gel ◽  
Pepstatin A

(1) Background: Nanomedicine has recently emerged as a new area of research, particularly to fight cancer. In this field, we were interested in the vectorization of pepstatin A, a peptide which does not cross cell membranes, but which is a potent inhibitor of cathepsin D, an aspartic protease particularly overexpressed in breast cancer. (2) Methods: We studied two kinds of nanoparticles. For pepstatin A delivery, mesoporous silica nanoparticles with large pores (LPMSNs) and hollow organosilica nanoparticles (HOSNPs) obtained through the sol–gel procedure were used. The nanoparticles were loaded with pepstatin A, and then the nanoparticles were incubated with cancer cells. (3) Results: LPMSNs were monodisperse with 100 nm diameter. HOSNPs were more polydisperse with diameters below 100 nm. Good loading capacities were obtained for both types of nanoparticles. The nanoparticles were endocytosed in cancer cells, and HOSNPs led to the best results for cancer cell killing. (4) Conclusions: Mesoporous silica-based nanoparticles with large pores or cavities are promising for nanomedicine applications with peptides.

Mesoporous Silica Nanoparticles Are Nanocarrier for Drug Loading and Induces Cell Death in Breast Cancer

2021 ◽  
pp. 225-245
Author(s):  
Lakshminarasimhan Harini ◽  
Karthikeyan Bose ◽  
T. Mohan Viswanathan ◽  
Nachimuthu Senthil Kumar ◽  
Krishnan Sundar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading
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