A Nanoparticle Carrier for Co-Delivery of Gemcitabine and Small Interfering RNA in Pancreatic Cancer Therapy

2016 ◽  
Vol 12 (8) ◽  
pp. 1654-1666 ◽  
Author(s):  
Jiajia Li ◽  
Yinting Chen ◽  
Linjuan Zeng ◽  
Guoda Lian ◽  
Shaojie Chen ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Therapy ◽  
Small Interfering Rna ◽  
Pancreatic Cancer Therapy ◽  
Interfering Rna

scholarly journals RNAi-Based Approaches for Pancreatic Cancer Therapy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1638
Author(s):  
Min Ju Kim ◽  
Hyeyoun Chang ◽  
Gihoon Nam ◽  
Youngji Ko ◽  
Sun Hwa Kim ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Therapy ◽  
Therapeutic Potential ◽  
Treatment Strategies ◽  
Tumor Formation ◽  
Cancer Models ◽  
Tumor Delivery ◽  
Pancreatic Cancer Therapy ◽  
Interfering Rna ◽  
Patient Survival Rate

Pancreatic cancer is one of the most lethal forms of cancer, predicted to be the second leading cause of cancer-associated death by 2025. Despite intensive research for effective treatment strategies and novel anticancer drugs over the past decade, the overall patient survival rate remains low. RNA interference (RNAi) is capable of interfering with expression of specific genes and has emerged as a promising approach for pancreatic cancer because genetic aberrations and dysregulated signaling are the drivers for tumor formation and the stromal barrier to conventional therapy. Despite its therapeutic potential, RNA-based drugs have remaining hurdles such as poor tumor delivery and susceptibility to serum degradation, which could be overcome with the incorporation of nanocarriers for clinical applications. Here we summarize the use of small interfering RNA (siRNA) and microRNA (miRNA) in pancreatic cancer therapy in preclinical reports with approaches for targeting either the tumor or tumor microenvironment (TME) using various types of nanocarriers. In these studies, inhibition of oncogene expression and induction of a tumor suppressive response in cancer cells and surrounding immune cells in TME exhibited a strong anticancer effect in pancreatic cancer models. The review discusses the remaining challenges and prospective strategies suggesting the potential of RNAi-based therapeutics for pancreatic cancer.

MDM2 Inhibitors for Pancreatic Cancer Therapy

2010 ◽  
Vol 999 (999) ◽  
pp. 1-9
Author(s):  
A. S. Azmi ◽  
P. A. Philip ◽  
K. Almhanna ◽  
F. W. Beck ◽  
Z. K. Kafri ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Therapy ◽  
Pancreatic Cancer Therapy

290 Novel Mcl-1 inhibitors for pancreatic cancer therapy

2010 ◽  
Vol 8 (7) ◽  
pp. 94
Author(s):  
Z. Nikolovska-Coleska ◽  
N. Bajwa ◽  
M. Liu ◽  
A. Azmi ◽  
J. Stuckey ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Therapy ◽  
Pancreatic Cancer Therapy

Invadopodia: A potential target for pancreatic cancer therapy

2021 ◽  
Vol 159 ◽  
pp. 103236
Author(s):  
Yan Luo ◽  
Jisheng Hu ◽  
Yong Liu ◽  
Le Li ◽  
Yilong Li ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Therapy ◽  
Potential Target ◽  
Pancreatic Cancer Therapy

scholarly journals Bazedoxifene as a Novel GP130 Inhibitor for Pancreatic Cancer Therapy

2016 ◽  
Vol 15 (11) ◽  
pp. 2609-2619 ◽  
Author(s):  
Xiaojuan Wu ◽  
Yang Cao ◽  
Hui Xiao ◽  
Chenglong Li ◽  
Jiayuh Lin
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Therapy ◽  
Pancreatic Cancer Therapy

Penetration Cascade of Size Switchable Nanosystem in Desmoplastic Stroma for Improved Pancreatic Cancer Therapy

ACS Nano ◽  
2021 ◽  
Author(s):  
Xiaozheng Zhao ◽  
Xiao Yang ◽  
Xudong Wang ◽  
Xiao Zhao ◽  
Yinlong Zhang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Therapy ◽  
Desmoplastic Stroma ◽  
Pancreatic Cancer Therapy

P.153 PES-003, A NEW PRO-DRUG FOR PANCREATIC CANCER THERAPY

2010 ◽  
Vol 42 ◽  
pp. S157
Author(s):  
S. Polvani ◽  
M. Calamante ◽  
B. Ottanelli ◽  
V. Foresta ◽  
G. Pieraccini ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Therapy ◽  
Pancreatic Cancer Therapy

scholarly journals Targeting miRNAs for Pancreatic Cancer Therapy

2014 ◽  
Vol 20 (33) ◽  
pp. 5279-5286 ◽  
Author(s):  
Min Shi ◽  
DachengXie ◽  
Yong Gaod ◽  
Keping Xie
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Therapy ◽  
Pancreatic Cancer Therapy

Aptamer conjugated theragnostic multifunctional magnetic nanoparticles as a nanoplatform for pancreatic cancer therapy

RSC Advances ◽  
2013 ◽  
Vol 3 (43) ◽  
pp. 20579 ◽  
Author(s):  
Balasubramanian Sivakumar ◽  
Ravindran Girija Aswathy ◽  
Yutaka Nagaoka ◽  
Seiki Iwai ◽  
Kizhikkilot Venugopal ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Magnetic Nanoparticles ◽  
Cancer Therapy ◽  
Pancreatic Cancer Therapy
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