The Role of Exogenous Neural Stem Cells Transplantation in Cerebral Ischemic Stroke

2014 ◽  
Vol 10 (11) ◽  
pp. 3219-3230 ◽  
Author(s):  
Lukui Chen ◽  
Rong Qiu ◽  
Lushen Li ◽  
Dan He ◽  
Haiqin Lv ◽  
...  
Keyword(s):  
Stem Cells ◽  
Ischemic Stroke ◽  
Neural Stem Cells ◽  
Stem Cells Transplantation ◽  
Cerebral Ischemic Stroke ◽  
Cerebral Ischemic

scholarly journals Insight Into the Mechanisms and the Challenges on Stem Cell-Based Therapies for Cerebral Ischemic Stroke

2021 ◽  
Vol 15 ◽  
Author(s):  
Huiyong Liu ◽  
Sydney Reiter ◽  
Xiangyue Zhou ◽  
Hanmin Chen ◽  
Yibo Ou ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Ischemic Stroke ◽  
Potential Effect ◽  
Therapeutic Window ◽  
Ethical Challenges ◽  
Stroke Treatment ◽  
Lesion Core ◽  
Cerebral Ischemic Stroke ◽  
Cerebral Ischemic

Strokes are the most common types of cerebrovascular disease and remain a major cause of death and disability worldwide. Cerebral ischemic stroke is caused by a reduction in blood flow to the brain. In this disease, two major zones of injury are identified: the lesion core, in which cells rapidly progress toward death, and the ischemic penumbra (surrounding the lesion core), which is defined as hypoperfusion tissue where cells may remain viable and can be repaired. Two methods that are approved by the Food and Drug Administration (FDA) include intravenous thrombolytic therapy and endovascular thrombectomy, however, the narrow therapeutic window poses a limitation, and therefore a low percentage of stroke patients actually receive these treatments. Developments in stem cell therapy have introduced renewed hope to patients with ischemic stroke due to its potential effect for reversing the neurological sequelae. Over the last few decades, animal tests and clinical trials have been used to treat ischemic stroke experimentally with various types of stem cells. However, several technical and ethical challenges must be overcome before stem cells can become a choice for the treatment of stroke. In this review, we summarize the mechanisms, processes, and challenges of using stem cells in stroke treatment. We also discuss new developing trends in this field.

scholarly journals The evolving role of neuro-immune interaction in brain repair after cerebral ischemic stroke

2018 ◽  
Vol 24 (12) ◽  
pp. 1100-1114 ◽  
Author(s):  
Xin Wang ◽  
Wei Xuan ◽  
Zi-Yu Zhu ◽  
Yan Li ◽  
Hao Zhu ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Brain Repair ◽  
Cerebral Ischemic Stroke ◽  
Cerebral Ischemic

scholarly journals Role of angiogenesis in patients with cerebral ischemic stroke.

Stroke ◽  
1994 ◽  
Vol 25 (9) ◽  
pp. 1794-1798 ◽  
Author(s):  
J Krupinski ◽  
J Kaluza ◽  
P Kumar ◽  
S Kumar ◽  
J M Wang
Keyword(s):  
Ischemic Stroke ◽  
Cerebral Ischemic Stroke ◽  
Cerebral Ischemic

scholarly journals Overexpression of MicroRNA-145 Ameliorates Astrocyte Injury by Targeting Aquaporin 4 in Cerebral Ischemic Stroke

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Lifang Zheng ◽  
Wei Cheng ◽  
Xijia Wang ◽  
Zhigang Yang ◽  
Xiangling Zhou ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Ischemic Injury ◽  
Glucose Deprivation ◽  
Expression Levels ◽  
Cultured Astrocytes ◽  
Cerebral Ischemic Stroke ◽  
Cerebral Ischemic ◽  
Induced Apoptosis ◽  
Global Population

Cerebral ischemic stroke, which affects the global population, is a major disease with high incidence, mortality, and disability. Accumulating evidence has indicated that abnormal microRNA (miRNA) expression plays essential roles in the pathologies of ischemic stroke. Yet, the underlying regulatory mechanism of miRNAs in cerebral ischemic stroke remains unclear. We investigated the role of miR-145 in cerebral ischemic stroke and its potential mechanism in a model using primary cultured astrocytes. We detected the expression levels of miR-145 and its target gene AQP4 and assessed the role of miR-145 in cell death and apoptosis caused by oxygen-glucose deprivation (OGD). Bioinformatics analysis was used to explore the targets of miR-145. miR-145 expression levels were significantly decreased in primary astrocytes subjected to OGD. miR-145 overexpression promoted astrocyte health and inhibited OGD-induced apoptosis. AQP4 was a direct target of miR-145, and miR-145 suppressed AQP4 expression. Moreover, AQP4 enhanced astrocyte injury in ischemic stroke, and AQP4 knockdown diminished the miR-145-mediated protective effect on ischemic injury. Taken together, our results show that miR-145 plays an important role in protecting astrocytes from ischemic injury by downregulating AQP4 expression. These findings may highlight a novel therapeutic target in cerebral ischemic stroke.

scholarly journals The role of KATP channels in cerebral ischemic stroke and diabetes

2018 ◽  
Vol 39 (5) ◽  
pp. 683-694 ◽  
Author(s):  
Vivian Szeto ◽  
Nai-hong Chen ◽  
Hong-shuo Sun ◽  
Zhong-ping Feng
Keyword(s):  
Ischemic Stroke ◽  
Katp Channels ◽  
Cerebral Ischemic Stroke ◽  
Cerebral Ischemic
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