Micelles Based on Methoxy Poly(Ethylene Glycol)Cholesterol Conjugate for Controlled and Targeted Drug Delivery of a Poorly Water Soluble Drug

2012 ◽  
Vol 8 (5) ◽  
pp. 809-817 ◽  
Author(s):  
Junming Li ◽  
Zhiyao He ◽  
Shui Yu ◽  
Shuangzhi Li ◽  
Qing Ma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Targeted Drug Delivery ◽  
Water Soluble ◽  
Poly Ethylene Glycol ◽  
Water Soluble Drug ◽  
Poorly Water Soluble ◽  
Targeted Drug ◽  
Poly Ethylene ◽  
Poorly Water Soluble Drug

scholarly journals pH-Responsive Poly(Ethylene Glycol)-block-Polylactide Micelles for Tumor-Targeted Drug Delivery

2017 ◽  
Vol 18 (9) ◽  
pp. 2711-2722 ◽  
Author(s):  
Lin Xiao ◽  
Lixia Huang ◽  
Firmin Moingeon ◽  
Mario Gauthier ◽  
Guang Yang
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Targeted Drug Delivery ◽  
Ph Responsive ◽  
Poly Ethylene Glycol ◽  
Targeted Drug ◽  
Poly Ethylene

scholarly journals Fabrication of Poly(ethylene glycol) Capsules via Emulsion Templating Method for Targeted Drug Delivery

Polymers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1124 ◽  
Author(s):  
Shuang Yang ◽  
Feng Ding ◽  
Zhiliang Gao ◽  
Jianman Guo ◽  
Jiwei Cui ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Targeted Drug Delivery ◽  
Cyclic Peptides ◽  
Electrostatic Interactions ◽  
Poly Ethylene Glycol ◽  
Templating Method ◽  
Targeted Drug ◽  
Poly Ethylene ◽  
Emulsion Templating

To reduce nonspecific interactions and circumvent biological barriers, low-fouling material of poly(ethylene glycol) (PEG) is most used for the modification of drug nanocarriers. Herein, we report the fabrication of PEG capsules via the free-radical polymerization of linear PEG or 8-arm-PEG using an emulsion templating method for targeted drug delivery. Doxorubicin (DOX) could be loaded in capsules via electrostatic interactions. The obtained capsules composed of 8-arm-PEG result in a lower cell association (2.2%) compared to those composed of linear PEG (7.3%) and, therefore, demonstrate the stealth property. The functionalization of cyclic peptides containing Arg-Gly-Asp (cRGD) on PEG capsules induce high cell targeting to U87 MG cells. A cell cytotoxicity assay demonstrates the biocompatibility of PEG capsules and high drug delivery efficacy of the targeted capsules. The reported capsules with the stealth and targeting property provide a potential platform for improved drug delivery.

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