New Non-Invasive Way to Rescue Neurons in Spinal Cord Injury via Intranasal Administration of Nerve Growth Factor: Pilot Study

2016 ◽  
Vol 8 (1) ◽  
pp. 37-44 ◽  
Author(s):  
Alberto de Bellis ◽  
Luigi Aloe
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Nerve Growth Factor ◽  
Pilot Study ◽  
Growth Factor ◽  
Intranasal Administration ◽  
Nerve Growth ◽  
Non Invasive ◽  
Cord Injury

scholarly journals Effects of nerve growth factor neutralization on TRP channel expression in laser-captured bladder afferent neurons in mice with spinal cord injury

2018 ◽  
Vol 683 ◽  
pp. 100-103 ◽  
Author(s):  
Nobutaka Shimizu ◽  
Naoki Wada ◽  
Takahiro Shimizu ◽  
Takahisa Suzuki ◽  
Ei-ichiro Takaoka ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Trp Channel ◽  
Afferent Neurons ◽  
Nerve Growth ◽  
Cord Injury ◽  
Channel Expression

Nerve Growth Factor, Endothelin and Spinal Cord Injury in Lower Urinary Tract Dysfunction

2009 ◽  
Vol 1 ◽  
pp. S77-S79
Author(s):  
Teruyuki OGAWA ◽  
Satoshi SEKI ◽  
Shiro HIRAGATA ◽  
Kurumi SASATOMI ◽  
Izumi KAMO ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Urinary Tract ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Lower Urinary Tract ◽  
Lower Urinary Tract Dysfunction ◽  
Nerve Growth ◽  
Cord Injury ◽  
Lower Urinary

scholarly journals Nerve growth factor (NGF) with hypoxia response elements loaded by adeno-associated virus (AAV) combined with neural stem cells improve the spinal cord injury recovery

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Qiuji Wu ◽  
Ziyue Xiang ◽  
Yibo Ying ◽  
Zhiyang Huang ◽  
Yurong Tu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Neural Stem Cells ◽  
Histochemical Staining ◽  
Adeno Associated Virus ◽  
Nerve Growth ◽  
Cord Injury

AbstractThe ischemia and hypoxia microenvironment after spinal cord injury (SCI) makes SCI repair a challenging problem. With various stimulus, chances for neural stem cells (NSCs) to differentiate into neurons, astrocytes, oligodendrocytes are great and is considered as a potential source of the stem cell therapy to SCI. Our research used adeno-associated virus (AAV) to carry the target gene to transfect neural stem cells. Transfected NSCs can express nerve growth factor (NGF) navigated by five hypoxia-responsive elements (5HRE). Therefore, the 5HRE-NGF-NSCs could express NGF specifically in hypoxia sites to promote the tissue repair and function recovery. Based on the regeneration of neurocytes and promotion of the recovery found in SCI models, via locomotor assessment, histochemical staining and molecular examinations, our results demonstrated that 5HRE-NGF-NSCs could improve the motor function, neurons survival and molecules expression of SCI rats. Meanwhile, the downregulated expression of autophagy-related proteins indicated the inhibitive effect of 5HRE-NGF-NSCs on autophagy. Our research showed that 5HRE-NGF-NSCs contribute to SCI repair which might via inhibiting autophagy and improving the survival rate of neuronal cells. The new therapy also hampered the hyperplasia of neural glial scars and induced axon regeneration. These positive functions of 5HRE-NGF-NSCs all indicate a promising SCI treatment.

scholarly journals The effect of neutralization of nerve growth factor (NGF) on bladder and urethral dysfunction in mice with spinal cord injury

2018 ◽  
Vol 37 (6) ◽  
pp. 1889-1896 ◽  
Author(s):  
Naoki Wada ◽  
Takahiro Shimizu ◽  
Nobutaka Shimizu ◽  
William C. de Groat ◽  
Anthony J. Kanai ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Nerve Growth ◽  
Cord Injury
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