scholarly journals Regulatory T Cells Reduce Acute Lung Injury Fibroproliferation by Decreasing Fibrocyte Recruitment

2013 ◽  
Vol 48 (1) ◽  
pp. 35-43 ◽  
Author(s):  
Brian T. Garibaldi ◽  
Franco R. D’Alessio ◽  
Jason R. Mock ◽  
D. Clark Files ◽  
Eric Chau ◽  
...  
Keyword(s):  
T Cells ◽  
Acute Lung Injury ◽  
Regulatory T Cells ◽  
Lung Injury

scholarly journals Recovery from acute lung injury can be regulated via modulation of regulatory T cells and Th17 cells

2018 ◽  
Vol 88 (5) ◽  
pp. e12715 ◽  
Author(s):  
Linlin Wang ◽  
Xiaocen Wang ◽  
Lin Tong ◽  
Jian Wang ◽  
Maosen Dou ◽  
...  
Keyword(s):  
T Cells ◽  
Acute Lung Injury ◽  
Regulatory T Cells ◽  
Lung Injury ◽  
Th17 Cells

scholarly journals A Potential Role for Regulatory T Cells in Apoptotic Cell Clearance by Macrophages in a Murine Model of Acute Lung Injury

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Jonathan Proto ◽  
Manikandan Subramanian ◽  
Mohammed Islam ◽  
Jaime Hook ◽  
Galina Gusarova ◽  
...  
Keyword(s):  
T Cells ◽  
Acute Lung Injury ◽  
Regulatory T Cells ◽  
Lung Injury ◽  
Murine Model ◽  
Potential Role ◽  
Apoptotic Cell ◽  
Apoptotic Cell Clearance ◽  
Cell Clearance

Lung-Resident Mesenchymal Stem Cells Promote Repair of LPS-Induced Acute Lung Injury via Regulating the Balance of Regulatory T cells and Th17 cells

Inflammation ◽  
2018 ◽  
Vol 42 (1) ◽  
pp. 199-210 ◽  
Author(s):  
Linlin Wang ◽  
Meng Shi ◽  
Lin Tong ◽  
Jian Wang ◽  
Shimeng Ji ◽  
...  
Keyword(s):  
Stem Cells ◽  
T Cells ◽  
Mesenchymal Stem Cells ◽  
Acute Lung Injury ◽  
Regulatory T Cells ◽  
Lung Injury ◽  
Th17 Cells

scholarly journals The Modulation of Regulatory T Cells via HMGB1/PTEN/β-Catenin Axis in LPS Induced Acute Lung Injury

2019 ◽  
Vol 10 ◽  
Author(s):  
Min Zhou ◽  
Haoshu Fang ◽  
Min Du ◽  
Changyong Li ◽  
Rui Tang ◽  
...  
Keyword(s):  
T Cells ◽  
Acute Lung Injury ◽  
Regulatory T Cells ◽  
Lung Injury

scholarly journals Delayed Akt suppression in the lipopolysaccharide-induced acute lung injury promotes resolution that is associated with enhanced effector regulatory T cells

2020 ◽  
Vol 318 (4) ◽  
pp. L750-L761 ◽  
Author(s):  
Sandeep Artham ◽  
Arti Verma ◽  
Abdulrahman Alwhaibi ◽  
Mir S. Adil ◽  
Santhakumar Manicassamy ◽  
...  
Keyword(s):  
T Cells ◽  
Acute Lung Injury ◽  
Regulatory T Cells ◽  
Lung Injury ◽  
Adaptive Immune Response ◽  
Foxp3 Expression ◽  
Control Group ◽  
Neutrophil Activity ◽  
Significant Impairment

The adaptive immune response could play a major role in the resolution of lung injury. Although regulatory T cells (Tregs) have been implicated in promoting the resolution of lung injury, therapeutic strategies to enhance Treg quantity and activity at the site of injury need further exploration. In the current study, Akt inhibition using triciribine (TCBN), given 48 h after lipopolysaccharide (LPS) administration, increased Tregs-promoted resolution of acute lung injury (ALI). TCBN treatment enhanced the resolution of LPS-induced ALI on day 7 by reducing pulmonary edema and neutrophil activity associated with an increased number of CD4+/FoxP3+/CD103+ and CTLA4+ effector Tregs, specifically in the injured lungs and not in the spleen. Treatment of EL-4 T-lymphocytes with two Akt inhibitors (TCBN and MK-2206) for 72 h resulted in increased FoxP3 expression in vitro. On the other end, Treg-specific PTEN knockout (PTENTreg KO) mice that have a higher Akt activity in its Tregs exhibited a significant impairment in ALI resolution, increased edema, and neutrophil activity associated with a reduced number of CD4+/FoxP3+/CD103+ and CTLA4+ effector Tregs as compared with the control group. In conclusion, our study identifies a potential target for the treatment of late-stage ALI by promoting resolution through effector Treg-mediated suppression of inflammation.

scholarly journals CD73 + regulatory T cells contribute to adenosine‐mediated resolution of acute lung injury

2013 ◽  
Vol 27 (6) ◽  
pp. 2207-2219 ◽  
Author(s):  
Heidi Ehrentraut ◽  
Eric T. Clambey ◽  
Eoin N. McNamee ◽  
Kelley S. Brodsky ◽  
Stefan F. Ehrentraut ◽  
...  
Keyword(s):  
T Cells ◽  
Acute Lung Injury ◽  
Regulatory T Cells ◽  
Lung Injury
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